Properties of microcrystalline cellulose and powder cellulose after extrusion/spheronization as studied by Fourier transform Raman spectroscopy and environmental scanning electron microscopy

AAPS PharmSci

Volumn 5, Issue 4, 2003, Pages

  Fechner, Petra M ^a   Wartewig, Siegfried ^a   Füting, Manfred ^b   Heilmann, Andreas ^b   Neubert, Reinhard H H ^a   Kleinebudde, Peter ^c  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b FRAUNHOFER INSTITUTE FOR MECHANICS OF MATERIALS IWM   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Environmental scanning electron microscopy; Extrusion spheronization; Microcrystalline cellulose; Pellet; Powder cellulose; Raman spectroscopy

Indexed keywords

CELLULOSE DERIVATIVE; MICROCRYSTALLINE CELLULOSE; WATER; CELLULOSE; EXCIPIENT; POLYMETHACRYLIC ACID DERIVATIVE; SPHERONS;

ARTICLE; CHEMICAL PARAMETERS; CONTROLLED STUDY; DRUG MANUFACTURE; FOURIER ANALYSIS; MATERIALS HANDLING; PARTICLE SIZE; PELLET EXTRUSION; POWDER; QUALITY CONTROL; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; SPHERONIZATION; WATER CONTENT; CHEMISTRY; PHYSICAL CHEMISTRY;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; EXCIPIENTS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; POWDERS; SPECTRUM ANALYSIS, RAMAN;

EID: 55449090061     PISSN: 15221060     EISSN: None     Source Type: Journal    
DOI: 10.1208/ps050431     Document Type: Article

References (21)

1. Wallace JW. Cellulose derivatives and natural products utilized in pharmaceutics. In: Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. New York, NY: Marcel Dekker; 1991;319-337.
2. Newton JM. Extrusion and extruders. In: Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. New York, NY: Marcel Dekker; 2002;1220-1236.
3. Edwards HGM, Farwell DW, Williams AC. FT-Raman spectrum of cotton: a polymeric biomolecular analysis. Spectrochim Acta A Mol Biomol Spectrosc. 1994;50A(4):807-811.
4. Langkilde FW, Svantesson A. Identification of celluloses with Fourier-Transform (FT) mid-infrared, FT-Raman and near-infrared spectrometry. J Pharm Biomed Anal. 1995;13(4/5):409-414.
5. Hopfe J, Füting M. Fundamentals and applications of environmental scanning electron microscopy. In: Wetzig K, Schulze D, eds. In Situ Scanning Electron Microscopy in Materials Research. Berlin, Germany: Akademie Verlag GmbH; 1995:219-240.
6. Baert L, Remon JP, Knight P, Newton JM. A comparison between the extrusion forces and sphere quality of a gravity feed extruder and a ram extruder. Int J Pharm. 1992;86:187-192.
7. Dietrich R. Food technology transfers to pellet production. Manuf Chemist. 1989;60:Aug:29-33.
8. Harrison PJ, Newton JM, Rowe RC. Flow defects in wet powder mass extrusion. J Pharm Pharmacol. 1985;37:81-83.
9. Kleinebudde P, Lindner H. Experiments with an instrumented twin-screw extruder using a single-step granulation/extrusion process. Int J Pharm. 1994;94:49-58.
10. Fielden KE, Newton JM, O'Brien P, Rowe RC. Thermal studies on the interaction of water and microcrystalline cellulose. J Pharm Pharmacol. 1988;40:674-678.
11. Kleinebudde P. The crystallite-gel-model for microcrystalline cellulose in wet-granulation, extrusion, and spheronization. Pharm Res. 1997;14(6):804-809.
12. Kleinebudde P, Jumaa M, Saleh FE. Influence of degree of polymerization on behavior of cellulose during homogenization and extrusion/spheronization. AAPS PharmSci. 2000;2 (2):article 21.
13. Jumaa M, Saleh FE, Hassan I, Müller BW, Kleinebudde P. Influence of cellulose type on the properties of extruded pellets, I: physicochemical characterisation of the cellulose types after homogenisation. Colloid Polym Sci. 2000;278(7):597-607.
14. Heng PWS, Koo OMY. A study of the effects of the physical characteristics of microcrystalline cellulose on performance in extrusion spheronization. Pharm Res. 2001;18 (4):480-487.
15. Kristensen J, Schaefer T, Kleinebudde P. Direct pelletization in a rotary processor controlled by torque measurements, II: effect of changes in the content of microcrystalline cellulose. AAPS PharmSci. 2000;2(3):article 24.
16. MacRitchie KA, Newton JM, Rowe RC. The evaluation of the rheological properties of lactose/microcrystalline cellulose and water mixtures by controlled stress rheometry and the relationship to the production of spherical pellets by extrusion/spheronization. Eur J Pharm Sci. 2002;17:43-50.
17. Law MFL, Deasy PB. Use of hydrophilic polymers with microcrystalline cellulose to improve extrusion-spheronization. Eur J Pharm Biopharm. 1998;45:57-65.
18. Lindner H, Kleinebudde P. Use of powdered cellulose for the production of pellets by extrusion/spheronization. J Pharm Pharmacol. 1994;46:2-7.
19. Saleh FE, Jumaa M, Hassan I, Kleinebudde P. Influence of cellulose type on the properties of extruded pellets, II: production and properties of pellets. STP Pharm Sci. 2000;10(5):379-385.
20. Koo OMY, Heng PWS. The influence of microcrystalline cellulose grade on shape and shape distributions of pellets produced by extrusion-spheronization. Chem Pharm Bull. 2001;49 (11):1383-1387.
21. Blackwell J, Vasko PD, Koenig JL. Infrared and Raman spectra of the cellulose from the cell wall of Valonia ventricosa. J Appl Phys. 1970;41:4375-4379.