Up-regulation of α-catenin is associated with increased lymph node involvement in colorectal cancer

World Journal of Gastroenterology

Volumn 14, Issue 31, 2008, Pages 4903-4908

  Elzagheid, Adam ^a,b   Buhmeida, Abdelbaset ^c   Korkeila, Eija ^c   Collan, Yrjö ^a   Syrjänen, Kari ^c   Pyrhönen, Seppo ^c  

^a UNIVERSITY OF TURKU   (Finland)

^b AL ARAB MEDICAL UNIVERSITY   (Libyan Arab Jamahiriya)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Alpha catenin; Colorectal carcinoma; Cytoplasmic staining; Membrane staining; Prognosis

Indexed keywords

ALPHA CATENIN; BETA CATENIN; TUMOR MARKER;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; CARCINOGENESIS; CELLULAR DISTRIBUTION; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; PROGNOSIS; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; RISK ASSESSMENT; CANCER STAGING; CHEMISTRY; COLORECTAL TUMOR; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; PATHOLOGY; PROSPECTIVE STUDY; TIME; TREATMENT OUTCOME; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; ALPHA CATENIN; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 55449085463     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.4903     Document Type: Article

References (26)

1. Breen E, Steele G Jr, Mercurio AM. Role of the E-cadherin/ alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells. Ann Surg Oncol 1995; 2: 378-385
2. Ahmad A, Hart IR. Mechanisms of metastasis. Crit Rev Oncol Hematol 1997; 26: 163-173
3. Shiozaki H, Iihara K, Oka H, Kadowaki T, Matsui S, Gofuku J, Inoue M, Nagafuchi A, Tsukita S, Mori T. Immunohistochemical detection of alpha-catenin expression in human cancers. Am J Pathol 1994; 144: 667-674
4. van der Wurff AA, Vermeulen SJ, van der Linden EP, Mareel MM, Bosman FT, Arends JW. Patterns of alpha-and beta-catenin and E-cadherin expression in colorectal adenomas and carcinomas. J Pathol 1997; 182: 325-330
5. Takayama T, Shiozaki H, Doki Y, Oka H, Inoue M, Yamamoto M, Tamura S, Shibamoto S, Ito F, Monden M. Aberrant expression and phosphorylation of beta-catenin in human colorectal cancer. Br J Cancer 1998; 77: 605-613
6. Gofuku J, Shiozaki H, Tsujinaka T, Inoue M, Tamura S, Doki Y, Matsui S, Tsukita S, Kikkawa N, Monden M. Expression of E-cadherin and alpha-catenin in patients with colorectal carcinoma. Correlation with cancer invasion and metastasis. Am J Clin Pathol 1999; 111: 29-37
7. Hugh TJ, Dillon SA, O'Dowd G, Getty B, Pignatelli M, Poston GJ, Kinsella AR. beta-catenin expression in primary and metastatic colorectal carcinoma. Int J Cancer 1999; 82: 504-511
8. Conacci-Sorrell M, Zhurinsky J, Ben-Ze'ev A. The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest 2002; 109: 987-991
9. Ozawa M, Kemler R. Molecular organization of the uvomorulin-catenin complex. J Cell Biol 1992; 116: 989-996
10. Aberle H, Schwartz H, Kemler R. Cadherin-catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem 1996; 61: 514-523
11. Adams CL, Nelson WJ, Smith SJ. Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion. J Cell Biol 1996; 135: 1899-1911
12. Aaltomaa S, Lipponen P, Ala-Opas M, Eskelinen M, Kosma VM. Alpha-catenin expression has prognostic value in local and locally advanced prostate cancer. Br J Cancer 1999; 80: 477-482
13. Bohm J, Niskanen L, Kiraly K, Kellokoski J, Eskelinen M, Hollmen S, Alhava E, Kosma VM. Expression and prognostic value of alpha-, beta-, and gamma-catenins indifferentiated thyroid carcinoma. J Clin Endocrinol Metab 2000; 85: 4806-4811
14. Li CC, Xu B, Hirokawa M, Qian Z, Yoshimoto K, Horiguchi H, Tashiro T, Sano T. Alterations of E-cadherin, alpha-catenin and beta-catenin expression in neuroendocrine tumors of the gastrointestinal tract. Virchows Arch 2002; 440: 145-154
15. Koksal IT, Ates M, Danisman A, Sezer C, Ciftcioglu A, Karpuzoglu G, Sevuk M. Reduced E-cadherin and alpha-catenin expressions have no prognostic role in bladder carcinoma. Pathol Oncol Res 2006; 12: 13-19
16. Elzagheid A, Kuopio T, Ilmen M, Collan Y. Prognostication of invasive ductal breast cancer by quantification of E-cadherin immunostaining: the methodology and clinic relevance. Histopathology 2002; 41: 127-133
17. Elzagheid A, Algars A, Bendardaf R, Lamlum H, Ristamaki R, Collan Y, Syrjanen K, Pyrhonen S. E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome. World J Gastroenterol 2006; 12: 4304-4309
18. Lipponen P, Collan Y. Simple quantitation of immunohistochemical staining positivity in microscopy. Acta Stereol 1992; 11: 125-132
19. El-Bahrawy MA, Poulsom R, Jeffery R, Talbot I, Alison MR. The expression of E-cadherin and catenins in sporadic colorectal carcinoma. Hum Pathol 2001; 32: 1216-1224
20. El-Bahrawy MA, Talbot IC, Poulsom R, Jeffery R, Alison MR. The expression of E-cadherin and catenins in colorectal tumours from familial adenomatous polyposis patients. J Pathol 2002; 198: 69-76
21. Baldus SE, Monig SP, Huxel S, Landsberg S, Hanisch FG, Engelmann K, Schneider PM, Thiele J, Holscher AH, Dienes HP. MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis. Clin Cancer Res 2004; 10: 2790-2796
22. Feng Han Q, Zhao W, Bentel J, Shearwood AM, Zeps N, Joseph D, Iacopetta B, Dharmarajan A. Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. Cancer Lett 2006; 231: 129-137
23. Chung DC. The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis. Gastroenterology 2000; 119: 854-865
24. Loeb LA. A mutator phenotype in cancer. Cancer Res 2001; 61: 3230-3239
25. Yashiro M, Carethers JM, Laghi L, Saito K, Slezak P, Jaramillo E, Rubio C, Koizumi K, Hirakawa K, Boland CR. Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res 2001; 61: 2676-2683
26. Hilska M, Roberts PJ, Collan YU, Laine VJ, Kossi J, Hirsimaki P, Rahkonen O, Laato M. Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer. Int J Cancer 2007; 121: 714-723