Investigation of extracellular elastase, acid proteinase and phospholipase activities as putative virulence factors in clinical isolates of Aspergillus species

Journal of Basic Microbiology

Volumn 48, Issue 5, 2008, Pages 331-337

  Alp, Sehnaz ^a   Arikan, Sevtap ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Acid proteinase; Aspergillus; Elastase; Phospholipase; Virulence factor

Indexed keywords

ASPARTIC PROTEINASE; PANCREATIC ELASTASE; PHOSPHOLIPASE; VIRULENCE FACTOR;

ARTICLE; ASPERGILLOSIS; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGY;

ASPARTIC ENDOPEPTIDASES; ASPERGILLOSIS; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; HUMANS; PANCREATIC ELASTASE; PHOSPHOLIPASES; VIRULENCE FACTORS;

ASPERGILLUS; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER;

EID: 55449083640     PISSN: 0233111X     EISSN: 15214028     Source Type: Journal    
DOI: 10.1002/jobm.200700349     Document Type: Article

References (30)

1. Latge, J.P., 1999. Aspergillus fumigatus and aspergillosis. Clin. Microbiol. Rev., 12, 310-350.
2. Bouchara, J.P., Tronchin, G., Larcher, G. and Chabasse, D., 1995. The search for virulence determinants in Aspergillus fumigatus. Trends Microbiol., 3, 327-330.
3. Tomee, J.F. and Kauffman, H.F., 2000. Putative virulence factors of Aspergillus fumigatus. Clin. Exp. Allergy, 30, 476-484.
4. Ghannoum, M.A., 2000. Potential role of phospholipases in virulence and fungal pathogenesis. Clin. Microbiol. Rev., 13, 122-143.
5. Larone, D.H., 1995. Medically Important Fungi: A Guide to Identification. 3rd edn. ASM Press, Washington, D.C.
6. Patterson, T.F., 2005. Aspergillus species. In: Mandell, G.L., Bennett, J.E. and Dolin, R. (eds.), Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases. 6th edn. Churchill, Livingstone, Philadelphia, Pennsylvania, pp. 2958-2973.
7. Kothary, M.H., Chase, T. and Macmillan, J.D., 1984. Correlation of elastase production by some strains of Aspergillus fumigatus with ability to cause pulmonary invasive aspergillosis in mice. Infect. Immun., 43, 320-325.
8. Blanco, J.L., Hontecillas, R., Bouza, E., Blanco, I., et al., 2002. Correlation between the elastase activity index and invasiveness of clinical isolates of Aspergillus fumigatus. J. Clin. Microbiol., 40, 1811-1813.
9. Staib, F., 1965. Serum proteins as nitrogen source for yeastlike fungi. Sabouraudia, 4, 187-193.
10. Federici, F. and Martini, A., 1982. Extracellular enzymatic activities in Aureobasidium pullulans. Mycologia, 74, 738-743.
11. Price, M.F., Wilkinson, I.D. and Gentry, L.O., 1982. Plate method for detection of phospholipase activity in Candida albicans. Sabouraudia, 20, 7-14.
12. Kolattukudy, P.E., Lee, J.D., Rogers, L.M., Zimmerman, P., et al., 1993. Evidence for possible involvement of an elastolytic serine protease in aspergillosis. Infect. Immun., 61, 2357-2368.
13. Starcher, B.C., 1986. Elastin and the lung. Thorax, 41, 577-585.
14. Rhodes, J.C., Bode, R.B. and McCuan-Kirsch, C.M., 1988. Elastase production in clinical isolates of Aspergillus. Diagn. Microbiol. Infect. Dis., 10, 165-170.
15. Hogan, L.H., Klein, B.S. and Levitz, S.M., 1996. Virulence factors of medically important fungi. Clin. Microbiol. Rev., 9, 469-488.
16. Piechura, J.E., Kurup, V.P. and Daft, L.J., 1990. Isolation and immunochemical characterization of fractions from membranes of Aspergillus fumigatus with protease activity. Can. J. Microbiol., 36, 33-41.
17. Reichard, U., Eiffert, H. and Ruchel, R., 1994. Purification and characterization of an extracellular aspartic proteinase from Aspergillus fumigatus. J. Med. Vet. Mycol., 32, 427-436.
18. Komatsu, S., Nishii, W., Sasaki, H., Muramatsu, T. and Tanokura, M., 1998. Substrate specificity of non-pepsin-type acid proteinase, Aspergillus niger proteinase A. Adv. Exp. Med. Biol., 436, 345-348.
19. Jönsson, A.G. and Martin, S.M., 1964. Protease production by Aspergillus fumigatus. Agr. Biol. Chem., 28, 734-739.
20. Birch, M., Robson, G., Law, D. and Denning, D.W., 1996. Evidence of multiple extracellular phospholipase activities of Aspergillus fumigatus. Infect. Immun., 64, 751-755.
21. Geoffroy, C., Raveneau, J., Beretti, J.L., Lecroisey, A., et al., 1991. Purification and characterization of an extracellular 29-kilodalton phospholipase C from Listeria monocytogenes. Infect. Immun., 59, 2382-2388.
22. Meyers, D.J., Palmer, K.C., Bale, L.A., Kernacki, K., et al., 1992. In vivo and in vitro toxicity of phospholipase C from Pseudomonas aeruginosa. Toxicon, 30, 161-169.
23. Titball, R.W., Hunter, S.E., Martin, K.L., Morris, B.C., et al., 1989. Molecular cloning and nucleotide sequence of the alpha-toxin (phospholipase C) of Clostridium perfringens. Infect. Immun., 57, 367-376.
24. Chen, S.C., Muller, M., Zhou, J.Z., Wright, L.C. and Sorrell, T.C., 1997. Phospholipase activity in Cryptococcus neoformans: a new virulence factor? J. Infect. Dis., 175, 414-420.
25. Cox, G.M., McDade, H.C., Chen, S.C., Tucker, S.C., et al., 2001. Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. Mol. Microbiol., 39, 166-175.
26. Ibrahim, A.S., Mirbod, F., Filler, S.G., Banno, Y., et al., 1995. Evidence implicating phospholipase as a virulence factor of Candida albicans. Infect. Immun., 63, 1993-1998.
27. Samaranayake, L.P., Raeside, J.M. and MacFarlane, T.W., 1984. Factors affecting the phospholipase activity of Candida species in vitro. Sabouraudia, 22, 201-207.
28. Muhsin, T.M., Aubaid, A.H. and Al-Duboon, A.H., 1997. Extracellular enzyme activities of dermatophytes and yeast isolates on solid media. Mycoses, 40, 465-469.
29. Birch, M., Denning, D.W. and Robson, G.D., 2004. Comparison of extracellular phospholipase activities in clinical and environmental Aspergillus fumigatus isolates. Med. Mycol., 42, 81-86.
30. Madan, T., Eggleton, P., Kishore, U., Strong, P., et al., 1997. Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect. Immun., 65, 3171-3179.