Stabilization of rasburicase and physico-chemical characterization of the resulting injectable formulation

Drug Development and Industrial Pharmacy

Volumn 30, Issue 8, 2004, Pages 877-889

  Bayol, Alain ^a   Breul, Thierry ^a   Dupin, Patrice ^a   Menegotto, Jérome ^a   Aleman, C ^a   Duplaa, Hélène ^a   Faure, Philippe ^a   Bonnet, Marie Claude ^a   Bauer, Michel ^a  

^a SANOFI   (France)

Author keywords

Chromatography; Differential scanning calorimetry; Lyophilisate; Rasburicase; Thermostimulated current spectroscopy; Uricase

Indexed keywords

8 AZAHYPOXANTHINE; 8 AZAXANTHINE; ALANINE; ALPHA CYCLODEXTRIN; ASPARTIC ACID; BETA CYCLODEXTRIN; BUFFER; CYSTEINE; EDETATE SODIUM; EXCIPIENT; GAMMA CYCLODEXTRIN; GLUTAMIC ACID; HISTIDINE; LACTOSE; MANNITOL; OROTIC ACID; PHOSPHATE; RASBURICASE; UNCLASSIFIED DRUG; XANTHINE; XANTHINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG STABILITY; ENZYME ACTIVITY; EXCIPIENT COMPATIBILITY; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; ISOELECTRIC FOCUSING; OSMOLALITY; PH; PHYSICAL CHEMISTRY; PROTEIN STABILITY; THERMAL STIMULATION; X RAY DIFFRACTION;

ALANINE; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DRUG COMBINATIONS; DRUG INCOMPATIBILITY; DRUG STABILITY; DRUG STORAGE; ENZYME STABILITY; EXCIPIENTS; FREEZE DRYING; HUMANS; HYPERURICEMIA; INFUSIONS, INTRAVENOUS; MANNITOL; PHARMACEUTICAL SOLUTIONS; POWDERS; RECOMBINANT PROTEINS; TEMPERATURE; URATE OXIDASE;

EID: 5544283593     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-200034582     Document Type: Article

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