-
1
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2000;2:423-427.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
-
2
-
-
33748976883
-
To predict progression-free survival and overall survival in metastatic renal cancer treated with sorafenib: Pilot study using dynamic contrast-enhanced Doppler ultrasound
-
Lamuraglia M, Escudier B, Chami L, et al. To predict progression-free survival and overall survival in metastatic renal cancer treated with sorafenib: pilot study using dynamic contrast-enhanced Doppler ultrasound. Eur J Cancer. 2006;42:2472-2479.
-
(2006)
Eur J Cancer
, vol.42
, pp. 2472-2479
-
-
Lamuraglia, M.1
Escudier, B.2
Chami, L.3
-
3
-
-
33646684668
-
Surrogate markers of activity of AG-013736, a multi-target tyrosine kinase receptor inhibitor, in metastatic renal cell cancer (RCC)
-
abstract 3003
-
Rixe O, Meric J, Bloch J, et al. Surrogate markers of activity of AG-013736, a multi-target tyrosine kinase receptor inhibitor, in metastatic renal cell cancer (RCC). J Clin Oncol. 2005;23(380s):abstract 3003.
-
(2005)
J Clin Oncol
, vol.23
, Issue.380 S
-
-
Rixe, O.1
Meric, J.2
Bloch, J.3
-
4
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers CJ, Martin MM, Brunn GJ, et al. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 1995;270:815-822.
-
(1995)
J Biol Chem
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
-
5
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4:335-348.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
6
-
-
33745242315
-
Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
-
DelBufalo D, Ciuffreda L, Trisciuoglio D, et al. Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res. 2006;66:5549-5554.
-
(2006)
Cancer Res
, vol.66
, pp. 5549-5554
-
-
DelBufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
-
7
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
Thomas GV, Tran C, Mellinghoff IK, et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med. 2006;12:122-127.
-
(2006)
Nat Med
, vol.12
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
-
8
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y, et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet. 1994;7:85-90.
-
(1994)
Nat Genet
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
9
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med. 2003;349:427-434.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
10
-
-
35648938219
-
Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer
-
Bukowski RM, Kabbinavar FF, Figlin RA, et al. Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer. J Clin Oncol 2007;25: 4536-4541.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4536-4541
-
-
Bukowski, R.M.1
Kabbinavar, F.F.2
Figlin, R.A.3
-
11
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
-
Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet. 2007;370:2103-2111.
-
(2007)
Lancet
, vol.370
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
12
-
-
43249085165
-
CALGB 90206: A phase III trial of bevacizumab plus interferon-alpha monotherapy in metastatic renal cell carcinoma
-
abstract 350, Presented at the February 14-16, San Francisco, CA
-
Rini B, Halabi S, Rosenberg J, et al. CALGB 90206: a phase III trial of bevacizumab plus interferon-alpha monotherapy in metastatic renal cell carcinoma [abstract 350], Presented at the ASCO Genitourinary Cancers Symposium; February 14-16, 2008; San Francisco, CA.
-
(2008)
ASCO Genitourinary Cancers Symposium
-
-
Rini, B.1
Halabi, S.2
Rosenberg, J.3
-
13
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer RJ, Michaelson MD, Redman BG, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 2006;24:16-24.
-
(2006)
J Clin Oncol
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
-
14
-
-
33744954585
-
Sunitinib in patients with metastatic renal cell carcinoma
-
Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA. 2006;295:2516-2524.
-
(2006)
JAMA
, vol.295
, pp. 2516-2524
-
-
Motzer, R.J.1
Rini, B.I.2
Bukowski, R.M.3
-
15
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer R, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356:115-124.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.1
Hutson, T.E.2
Tomczak, P.3
-
16
-
-
48649094719
-
Overall survival with sunitinib versus interferon-alfa (IFN-α) as first-line treatment of metastatic renal cell carcinoma (mRCC)
-
abstract 5024
-
Figlin R, Hutson TE, Tomczak P, et al. Overall survival with sunitinib versus interferon-alfa (IFN-α) as first-line treatment of metastatic renal cell carcinoma (mRCC). Proc ASCO. 2008, abstract 5024.
-
(2008)
Proc ASCO
-
-
Figlin, R.1
Hutson, T.E.2
Tomczak, P.3
-
17
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
Ratain MJ, Eisen T, Stadler WM, et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol. 2006;24:2505-2512.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
-
18
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356:125-134.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
19
-
-
34548315347
-
Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: Survival and biomarker analysis
-
abstract 5023
-
Bukowski RM, Eisen T, Szcylick C, et al. Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis. J Clin Oncol. 2007;25(18s):abstract 5023.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Bukowski, R.M.1
Eisen, T.2
Szcylick, C.3
-
20
-
-
35548931472
-
Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: Final results
-
18s, abstract 5025
-
Szczylik, C, Demkoff T, Staehler M, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. J Clin Oncol. 2007;25( 18s): abstract 5025.
-
(2007)
J Clin Oncol
, vol.25
-
-
Szczylik, C.1
Demkoff, T.2
Staehler, M.3
-
21
-
-
35448934762
-
Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
-
Rixe O, Bukowski RM, Michaelson MD, et al. Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol. 2007;8:975-984.
-
(2007)
Lancet Oncol
, vol.8
, pp. 975-984
-
-
Rixe, O.1
Bukowski, R.M.2
Michaelson, M.D.3
-
22
-
-
35549007093
-
Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib
-
abstract 5032
-
Rini BI, Wilding GT, Hudes G, et al. Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib. J Clin Oncol. 2007;25(18s):abstract 5032.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Rini, B.I.1
Wilding, G.T.2
Hudes, G.3
-
23
-
-
35548997095
-
Pazopanib (GW786034) is active in metastatic renal cell carcinoma: Interim results of a phase II randomized discontinuation trial
-
abstract 5031
-
Hutson TE, Davis ID, Machiels JP, et al. Pazopanib (GW786034) is active in metastatic renal cell carcinoma: interim results of a phase II randomized discontinuation trial. J Clin Oncol. 2007;25(18s):abstract 5031.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.P.3
-
24
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins MB, Hidalgo M, Stadler WM, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol. 2004;22:909-918.
-
(2004)
J Clin Oncol
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
-
25
-
-
34249779568
-
Temsirolimus, Interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, Interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356: 2271-2281.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
26
-
-
35548977012
-
A phase II trial of RAD001 in patients (pts) with metastatic renal cell carcinoma (MRCC)
-
abstract 5107
-
Jac J, Giessinger S, Khan M, et al. A phase II trial of RAD001 in patients (pts) with metastatic renal cell carcinoma (MRCC). J Clin Oncol. 2007;25(18s):abstract 5107.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Jac, J.1
Giessinger, S.2
Khan, M.3
-
27
-
-
55349118747
-
Everolimus for advanced renal cell carcinoma
-
Epub ahead of print
-
Motzer RJ, Escudier B, Oudard S, et al. Everolimus for advanced renal cell carcinoma. Lancet. 2008 [Epub ahead of print].
-
(2008)
Lancet
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
28
-
-
7944220649
-
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
-
Oliner J, Min H, Leal J, et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 2004;6: 507-516.
-
(2004)
Cancer Cell
, vol.6
, pp. 507-516
-
-
Oliner, J.1
Min, H.2
Leal, J.3
-
29
-
-
47249134321
-
Perifosine (P), active as a single agent for renal cell carcinoma (RCC), now in phase I trials combined with tyrosine kinase inhibitors (TKJ)
-
abstract 15622
-
Stephenson J, Schreeder M, Waples J, et al. Perifosine (P), active as a single agent for renal cell carcinoma (RCC), now in phase I trials combined with tyrosine kinase inhibitors (TKJ). J Clin Oncol. 2007; 25(18s):abstract 15622.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Stephenson, J.1
Schreeder, M.2
Waples, J.3
-
30
-
-
33750631676
-
Efficacy and safety of sunitinib malate in bevacizumab-refractory metastatic renal cell carcinoma
-
abstract 4522
-
Rini BI, George DI, Michaelson MD, et al. Efficacy and safety of sunitinib malate in bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol. 2006;24(18s):abstract 4522.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 S
-
-
Rini, B.I.1
George, D.I.2
Michaelson, M.D.3
-
31
-
-
37849001813
-
Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
-
Choueri T, Plantade A, Elson P, et al. Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J Clin Oncol. 2008;26:127-131.
-
(2008)
J Clin Oncol
, vol.26
, pp. 127-131
-
-
Choueri, T.1
Plantade, A.2
Elson, P.3
|