Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: A tissue microarray study

Journal of Experimental and Clinical Cancer Research

Volumn 27, Issue 1, 2008, Pages

  Liu, Zheng ^a   Fu, Qiang ^a   Lv, Jiaju ^a   Wang, Facheng ^a   Ding, Kejia ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CKS1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PROTEIN DERIVATIVE; S PHASE KINASE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG; CARRIER PROTEIN; CDKN1B PROTEIN, HUMAN; CKS1B PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; S PHASE KINASE ASSOCIATED PROTEIN; SIGNAL PEPTIDE;

ADRENAL METASTASIS; ADULT; AGED; ARTICLE; BONE METASTASIS; CANCER STAGING; CANCER SURVIVAL; CHROMOPHOBE ADENOMA; CLEAR CELL CARCINOMA; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLLOW UP; GASTROINTESTINAL TRACT METASTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY CARCINOMA; LUNG METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTIVARIATE ANALYSIS; PATHOLOGY; PRIMARY TUMOR; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SOFT TISSUE METASTASIS; TISSUE MICROARRAY; TUMOR NECROSIS; TUMOR VOLUME; UNIVARIATE ANALYSIS; COHORT ANALYSIS; KIDNEY TUMOR; METABOLISM; MIDDLE AGED; SURVIVAL;

CARCINOMA, RENAL CELL; CARRIER PROTEINS; COHORT STUDIES; CYCLIN-DEPENDENT KINASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; S-PHASE KINASE-ASSOCIATED PROTEINS; SURVIVAL ANALYSIS; TISSUE ARRAY ANALYSIS;

EID: 55349106606     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-27-51     Document Type: Article

References (27)

1. Recent advances in kidney cancer and metastatic disease. Z Kirkali E Tuzel MU Mungan, BJU Int 2001 88 818 824 10.1046/j.1464-4096.2001.02442.x 11736854
2. The changing evolution of renal tumors: a single center experience over a two-decade period. JJ Patard H Tazi K Bensalah, Eur Urol 2004 45 490 494 10.1016/j.eururo.2003.12.015 15041114
3. Cell cycle control in mammalian cells: role of cyclins, cyclin-dependent kinases (CDK), growth suppressor genes and inhibitors (CKIs). X Grana FP Reddy, Oncogene 1995 11 211 219 7624138
4. p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. RV Lloyd LA Erickson L Jin E Kulig X Qian JC Cheville BW Scheithauer, Am J Pathol 1999 154 313 323 10027389
5. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone or in combination, correlate with survival of young breast patients. PL Porter KE Malone PJ Heagerty GM Alexander LA Gatti EJ Firpo JR Daling JM Roberts, Nat Med 1997 3 222 225 10.1038/nm0297-222 9018243
6. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. M Pagano SW Tam AM Theodoras P Beer-Romero G Del Sal V Chau PR Yew GF Draetta M Rolfe, Science 1995 269 682 5 10.1126/science.7624798 7624798
7. A CDK-independent function of mammalian Cks1: targeting of SCF(SKP2) to the CDK inhibitor p27Kip1. C Spruck H Strohmaier M Watson AP Smith A Ryan TW Krek SI Reed, Mol Cell 2001 7 639 50 10.1016/S1097-2765(01)00210-6 11463388
8. Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis. TA Masuda H Inoue H Sonoda S Mine Y Yoshikawa T Nakayama T Nakayama M Mori, Cancer Res 2002 62 3819 3825 12097295
9. The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. D Ganoth G Bornstein TK Ko B Larsen M Tyers M Pagano A Hershko, Nat Cell Biol 2001 3 321 324 10.1038/35060126 11231585
10. The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma. M Shapira O Ben-Izhak S Linn B Futerman I Minkov DD Hershko, Cancer 2005 103 1336 1346 10.1002/cncr.20917 15717322
11. The expression of the ubiquitin ligase subunit Cks1 in human breast cancer. M Slotky M Shapira O Ben-Izhak S Linn B Futerman M Tsalic DD Hershko, Breast Cancer Res 2005 7 R737 744 16168119 10.1186/bcr1278
12. Amplification and overexpression of Skp2 are associated with metastasis of non-small-cell lung cancers to lymphnodes. S Yokoi K Yasui M Mori T Iizasa T Fujisawa J Inazawa, Am J Pathol 2004 165 175 180 15215173
13. Biological significance of p27 and Skp2 expression in renal cell carcinoma. A systematic analysis of primary and metastatic tumour tissues using a tissue microarray technique. C Langner R vonWasielewski M Ratschek P Rehak R Zigeuner, Virchows Arch 2004 445 631 6 10.1007/s00428-004-1121-2 15517366
14. TNM staging of renal cell carcinoma: Workgroup No.3 - Union International Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). P Guinan LH Sobin F Algaba F Badellino S Kameyama G MacLennan A Novick, Cancer 1997 80 992 993 10.1002/(SICI)1097-0142(19970901)80:5<992::AID-CNCR26>3.0. CO;2-Q 9307205
15. The Heidelberg classification of renal cell tumors. G Kovacs M Akhtar BJ Beckwith P Bugert CS Cooper B Delahunt JN Eble S Fleming B Ljungberg LJ Medeiros H Moch VE Reuter E Ritz G Roos D Schmidt JR Srigley S Störkel E van den Berg B Zbar, J Pathol 1997 183 131 133 10.1002/(SICI)1096-9896(199710)183: 2<131::AID-PATH931>3.0.CO;2-G 9390023
16. Prognostic significance of morphologic parameters in renal cell carcinoma. SA Fuhrman LC Lasky C Limas, Am J Surg Pathol 1982 6 655 663 7180965
17. Inverse relation between levels of p27kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. D Hershko G Bornstein O Ben-Izhak A Carrano M Pagano MM Krausz A Hershko, Cancer 2001 91 1745 1751 10.1002/1097-0142(20010501)91:9<1745::AID-CNCR1193>3.0.CO;2-H 11335900
18. Low p27 expression predicts poor disease-free survival in patients with prostate cancer. RM Yang J Naitoh M Murphy HJ Wang J Phillipson JB deKernion M Loda RE Reiter, J Urol 1998 159 941 5 10.1016/S0022-5347(01)63776-5 9474188
19. Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. J Tsihlias LR Kapusta G DeBoer I Morava-Protzner I Zbieranowski N Bhattacharya GC Catzavelos LH Klotz JM Slingerland, Cancer Res 1998 58 542 8 9458103
20. Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray. Y Hedberg B Ljungberg G Roos G Landberg, Br J Cancer 2003 88 1417 1423 10.1038/sj.bjc.6600922 12778072
21. Low expression of p27kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma. T Migita Y Oda S Naito M Tsuneyoshi, Cancer 2002 94 973 979 10.1002/cncr.10338 11920465
22. Expression of the cell cycle proteins p21, p27, and pRb in clear cell renal cell carcinoma and their prognostic significance. A Haitel HG Wiener B Neudert M Marberger M Susani, Urology 2001 58 477 481 10.1016/S0090-4295(01) 01188-8 11549509
23. Expression of cell cycle control proteins in primary colorectal tumors does not always predict expression in lymph node metastases. JA McKay JJ Douglas VG Ross S Curran FY Ahmed JF Loane GI Murray HL McLeod, Clin Cancer Res 2000 6 1113 1118 10741741
24. Tissue microarray analysis of the prognostic value of E-cadherin, Ki67, p53, p27, survivin and MSH2 expression in upper urinary tract transitional cell carcinoma. G Fromont M Rouprêt N Amira M Sibony G Vallancien P Validire O Cussenot, Eur Urol 2005 48 764 70 10.1016/j.eururo.2005.07.005 16126329
25. Skp2 overexpression is highly representative of intrinsic biological aggressiveness and independently associated with poor prognosis in primary localized myxofibrosarcomas. Hsuan-Ying Huang Hong-Yo Kang Chien-Feng Li Hock-Liew Eng Shih-Cheng Chou Ching-Nan Lin Ching-Yeh Hsiung, Clin Cancer Res 2006 12 487 498 10.1158/1078-0432.CCR-05-1497 16428491
26. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. T Kamura T Hara M Matsumoto N Ishida F Okumura S Hatakeyama M Yoshida K Nakayama KI Nakayama, Nat Cell Biol 2004 6 1229 1235 10.1038/ncb1194 15531880
27. Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma. TA Masuda H Inoue K Nishida H Sonoda Y Yoshikawa Y Kakeji T Utsunomiya M Mori, Clin Cancer Res 2003 9 15 5693 5698 14654553