Impaired inactivation of digestive proteases: A factor that may have confounded the efficacy of antibiotics aimed at reducing the exposure to luminal bacteria and their components

American Journal of Gastroenterology

Volumn 103, Issue 11, 2008, Pages 2955-2956

  Qin, Xiaofa ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PROBIOTIC AGENT; PROTEINASE;

ALLERGIC DISEASE; AUTOIMMUNE DISEASE; BACTEROIDES; ENTERITIS; LETTER; MULTIPLE SCLEROSIS; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; ENTEROBACTERIACEAE; HUMANS; INTESTINAL MUCOSA; PEPTIDE HYDROLASES;

EID: 55349094642     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2008.02094_17.x     Document Type: Letter

References (6)

1. Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology 2008 134 : 577 94.
2. Gionchetti P, Rizzello F, Lammers KM, et al. Antibiotics and probiotics in treatment of inflammatory bowel disease. World J Gastroenterol 2006 12 : 3306 13.
3. Qin X. Inactivation of digestive proteases: Another aspect of gut bacteria that should be taken into more consideration. World J Gastroenterol 2007 13 : 2390 1.
4. Ramare F, Hautefort I, Verhe F, et al. Inactivation of tryptic activity by a human-derived strain of Bacteroides distasonis in the large intestines of gnotobiotic rats and mice. Appl Environ Microbiol 1996 62 : 1434 6.
5. Qin X. Synergic effect of bacterial glycosidases and digestive proteases on mucus degradation and the reduced risk of inflammatory bowel disease-like gut damage in both germ-free and poor hygiene conditions. Inflamm Bowel Dis 2008 14 : 145 6.
6. Swank GM, Deitch EA. Role of the gut in multiple organ failure: Bacterial translocation and permeability changes. World J Surg 1996 20 : 411 7.