Inactivation of digestive proteases: Another aspect of gut bacteria that should be taken into more consideration

World Journal of Gastroenterology

Volumn 13, Issue 16, 2007, Pages 2390-2391

  Qin, Xiaofa ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME PRECURSOR; PROTEINASE; PROTEINASE INHIBITOR; SACCHARIN;

ENTERITIS; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME RELEASE; HUMAN; IMMUNOREGULATION; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; LETTER; MUCUS; PROTEIN DEGRADATION;

EID: 34249844135     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i16.2390     Document Type: Letter

References (20)

1. Ruthenburger M, Mayerle J, Lerch MM. Cell biology of pancreatic proteases. Endocrinol Metab Clin North Am 2006; 35: 313-331, ix
2. Atuma C, Strugala V, Allen A, Holm L. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am J Physiol Gastrointest Liver Physiol 2001; 280: G922-G929
3. Travis J, Salvesen GS. Human plasma proteinase inhibitors. Annu Rev Biochem 1983; 52: 655-709
4. Acosta JA, Hoyt DB, Schmid-Schonbein GW, Hugli TE, Anjaria DJ, Frankel DA, Coimbra R. Intraluminal pancreatic serine protease activity, mucosal permeability, and shock: a review. Shock 2006; 26: 3-9
5. Bounous G. "Tryptic enteritis": its role in the pathogenesis of stress ulcer and shock. Can J Surg 1969; 12: 397-409
6. Bounous G, Menard D, De Medicis E. Role of pancreatic proteases in the pathogenesis of ischemic enteropathy. Gastroenterology 1977; 73:102-108
7. Bounous G. Pancreatic proteases and oxygen-derived free radicals in acute ischemic enteropathy. Surgery 1986; 99: 92-94
8. Delaney JP, Bonsack M. Acute radiation enteritis in rats: bile salts and trypsin. Surgery 1992; 112: 587-592
9. Kimura RE, Arango V, Lloyd-Still J. Indomethacin and pancreatic enzymes synergistically damage intestine of rats. Dig Dis Sci 1998; 43: 2322-2332
10. Kimura RE, Dy SA, Uhing MR, Beno DW, Jiyamapa VA, Lloyd-Still JD. The effects of high-dose ibuprofen and pancreatic enzymes on the intestine of the rat. J Pediatr Gastroenterol Nutr 1999; 29: 178-183
11. Lloyd-Still JD, Uhing MR, Arango V, Fusaro A, Kimura RE. The effect of intestinal permeability on pancreatic enzyme-induced enteropathy in the rat. J Pediatr Gastroenterol Nutr 1998; 26: 489495
12. Soma LR, Neufeld GR, Dodd DC, Marshall BE. Pulmonary function in hemorrhagic shock: the effect of pancreatic ligation and blood filtration. Ann Surg 1974; 179: 395-402
13. De Koos EB, Gibson WJ, Bounous G, Hampson LG. The influence of pancreatic duct ligation on the course of E. coli endotoxin shock in the dog. Can J Surg 1966; 9: 227-230
14. Smith EE, Crowell JW, Moran CJ, Smith RA. Intestinal fluid loss in dogs during irreversible hemorrhagic shock. Surg Gynecol Obstet 1967; 125: 45-48
15. Bounous G, Hampson LG, Gurd FN. Cellular Nucleotides in Hemorrhagic Shock: Relationship of Intestinal Metabolic Changes to Hemorrhagic Enteritis and the Barrier Function of Intestinal Mucosa. Ann Surg 1964; 160: 650-668
16. Norin KE, Gustafsson BE, Midtvedt T. Strain differences in faecal tryptic activity of germ-free and conventional rats. Lab Anim 1986; 20: 67-69
17. Midtvedt T, Carlstedt-Duke B, Hoverstad T, Midtvedt AC, Norin KE, Saxerholt H. Establishment of a biochemically active intestinal ecosystem in ex-germfree rats. Appl Environ Microbiol 1987; 53: 2866-2871
18. Qin XF. Impaired inactivation of digestive proteases by deconjugated bilirubin: the possible mechanism for inflammatory bowel disease. Med Hypotheses 2002; 59:159-163
19. Qin X. Is the incidence of inflammatory bowel disease in the developed countries increasing again? Is that surprising? Inflamm Bowel Dis 2006 (Epub ahead of print)
20. Qin X. What caused the increase of autoimmune and allergic diseases: a decreased or an increased exposure to luminal microbial components? World J Gastroenterol 2007; 13:1306-1307