Preservation of platelet aggregation and dense granule secretion during extended storage of blood samples in the presence of a synthetic dual inhibitor of factor Xa and thrombin

Platelets

Volumn 19, Issue 7, 2008, Pages 496-501

  Haubelt, Hanne ^a   Vogt, Anette ^a   Hellstern, Peter ^a  

^a Academic City Hospital   (Germany)

Author keywords

Citrate; Inhibitor of factor Xa and thrombin; Platelet aggregation; Platelet secretion; Stability; Storage time

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BENZYL DERIVATIVE; BENZYLSULFONYL DEXTRO ARGINYLPROLYL 4 AMIDINOBENZYLAMIDE; BLOOD CLOTTING FACTOR 10A; CITRIC ACID; COLLAGEN; THROMBIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CLOTTING PARAMETERS; BLOOD SAMPLING; BLOOD STORAGE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE PRESERVATION;

ADULT; BLOOD PRESERVATION; BLOOD SPECIMEN COLLECTION; CYTOPLASMIC GRANULES; DIPEPTIDES; FACTOR XA; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; THROMBIN;

EID: 55349084386     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.1080/09537100802302225     Document Type: Article

References (17)

1. Mustard JF, Perry DW, Kinlough-Rathbone RL, Packham MA. Factors responsible for ADP-induced release reaction of human platelets. Am J Physiol 1975;228:1757-1765.
2. Heptinstall S, Taylor PM. The effects of citrate and extracellular calcium ions on the platelet release reaction induced by adenosine diphosphate and collagen. Thromb Haemost 1979;42:778-793.
3. Breddin HK. Can platelet aggregometry be standardized? Platelets 2005;16:151-158.
4. Harrison P. Platelet function analysis. Blood reviews 2005;19:111-123.
5. Hellstern P, Stürzebecher U, Wuchold B, Haubelt H, Seyfert UT, Bauer M, Vogt A, Hellstern P. Preservation of in vitro function of platelets stored in the presence of a synthetic dual inhibitor of factor Xa and thrombin. J Thromb Haemost 2007;5:2119-2126.
6. Feinman RD, Lubowski J, Charo I, Zabinski MP. The lumi-aggregometer: A new instrument for simultaneous measurement of secretion and aggregation by platelets. J Lab Clin Med 1977;90:125-129.
7. Schweinitz A, Stürzebecher A, Stürzebecher U, Schuster O, Stürzebecher J Steinmetzer T. New substrate analogue inhibitors of factor Xa containing 4-amidinobenzylamide as P1 residue: Part 1. Medicinal Chemistry 2006;2:349-361.
8. Seyfert UT, Haubelt H, Vogt A, Hellstern P. Variables influencing Multiplate whole blood impedance aggregometry and turbidimetric platelet aggregation in healthy individuals. Platelets 2007;18:199-206.
9. Glusa E. Hirudin and platelets. Sem Thromb Hemost 1981;17:122-125.
10. May JA, Heptinstall S. Effects of anticoagulants used during blood collection on human platelet function. Methods Mol Biol 2004;272:3-11.
11. Stafford NP, Pink AE, White AE, Glenn JR, Heptinstall S. Mechanisms involved in adenosine triphosphate- induced platelet aggregation in whole blood. Arterioscler Thromb Vasc Biol 2003;23:1928-1933.
12. Heptinstall S, Johnson A, Glenn JR, White AE. Adenine nucleotide metabolism in human blood - important roles of leukocytes and erythrocytes. J Thromb Haemost 2005;3:2331-2339.
13. Vallés J, Santos MT, Aznar J, Marcus AJ, Martinez-Sales V, Portoles M, Broekman MJ, Safier LB. Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment. Blood 1991;78:154-162.
14. Vallés J, Santos MT, Aznar J, Marcus AJ, Martinez M, Moscardó A, Piñón M, Broekman MJ, Marcua AJ. Platelet-erythrocyte interactions enhance αIIbβ3 integrin receptor activation and P-selectin expression during platelet recruitment: Down-regulation by aspirin ex vivo. Blood 2002;99:3978-3984.
15. Ingerman-Wojenski CM, Silver MJ. A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer. Thromb Haemost 1984;51:154-156.
16. Wallén NH, Ladievardi M, Albert J, Bröijersén A. Influence of different anticoagulants on platelet aggregation in whole blood: A comparison between citrate, low molecular mass heparin and hirudin. Thromb Res 1997;87:151-157.
17. Perneby C, Wallén NH, Rooney C, Fitzgerald D, Hjemdahl P. Dose- and time-dependent effects of aspirin. Thromb Haemost 2006;95:652-658.