Protective effects of N-Methyl-D-Aspartate receptor antagonism on VX-induced neuronal cell death in cultured rat cortical neurons

Neurotoxicity Research

Volumn 13, Issue 3-4, 2008, Pages 163-172

  Wang, Yushan ^a   Weiss, M Tracy ^a   Yin, Junfei ^b   Tenn, Catherine C ^a   Elson, Peggy D ^a   Mikler, John R ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT CANADA   (Canada)

^b Canada West Bioscience Inc   (Canada)

Author keywords

Apoptotic like cell death; Chemical; Excitatory amino acid receptors; Neuronal cell death; Organophosphorus nerve agents; Warfare agents

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; ACETYLCHOLINESTERASE; AMPA RECEPTOR; ATROPINE; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; ORGANOPHOSPHORUS COMPOUND; PHYSOSTIGMINE; PROPIDIUM IODIDE; 2,3 DIOXO 6 NITRO 7 SULFAMOYLBENZO(F)QUINOXALINE; 2,3-DIOXO-6-NITRO-7-SULFAMOYLBENZO(F)QUINOXALINE; AMINO ACID RECEPTOR BLOCKING AGENT; CHEMICAL WARFARE AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; DIAGNOSTIC AGENT; GLUTAMIC ACID; PHOSPHOROTHIOIC ACID DERIVATIVE; QUINOXALINE DERIVATIVE;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; FEMALE; IC 50; IMMUNOASSAY; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; STAINING; ANALYSIS OF VARIANCE; ANIMAL; CELL CULTURE; CELL DEATH; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; EMBRYO (ANATOMY); NERVE CELL; PATHOLOGY; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT; TIME;

RATTUS;

2-AMINO-5-PHOSPHONOVALERATE; ANALYSIS OF VARIANCE; ANIMALS; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CHEMICAL WARFARE AGENTS; CHOLINERGIC AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLUTAMIC ACID; NEURONS; ORGANOTHIOPHOSPHORUS COMPOUNDS; PREGNANCY; PROPIDIUM; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS;

EID: 55249124268     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033500     Document Type: Article

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