Reliability and reproducibility of N-[C]methyl-choline and L-(S-methyl-[C])methionine solid-phase synthesis: a useful and suitable method in clinical practice

Nuclear Medicine Communications

Volumn 29, Issue 8, 2008, Pages 736-740

  Lodi, Filippo ^a   Rizzello, Anna ^a   Trespidi, Silvia ^a   Di Pierro, Donato ^a   Marengo, Mario ^a   Farsad, Mohsen ^a   Fanti, Stefano ^a   Al Nahhas, Adil ^a   Rubello, Domenico ^a   Boschi, Stefano ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

PET radiopharmaceuticals; Solid phase synthesis

Indexed keywords

CARBON; CHOLINE; DRUG DERIVATIVE; METHIONINE; METHYLCHOLINE; RADIOPHARMACEUTICAL AGENT; CHOLINE C 11; METHIONINE C 11;

ARTICLE; CHEMISTRY; ISOTOPE LABELING; REPRODUCIBILITY; SYNTHESIS; CLINICAL PRACTICE; DRUG SYNTHESIS; HUMAN; METHYLATION; POSITRON EMISSION TOMOGRAPHY; QUALITY CONTROL; RADIOCHEMISTRY; RELIABILITY; SOLID PHASE SYNTHESIS;

CARBON RADIOISOTOPES; CHOLINE; ISOTOPE LABELING; METHIONINE; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS;

EID: 55249117489     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/MNM.0b013e3282ffb44c     Document Type: Article

References (15)

1. Kostakoglu L, Agress H, Goldsmith SF. Clinical role of FDG PET in evaluation of cancer patients. Radiographics 2003; 23:315-340.
2. Hara T, Kosaka N, Hiroichi K. PET imaging of prostate cancer using carbon-11-choline. J Nucl Med 1998; 39:990-995.
3. 11C-choline positron emission tomography. Eur Urol 2002; 42:18-23.
4. 11C-methionine PET for differential diagnosis of low-grade gliomas. Neurology 1998; 50:1316-1322.
5. Jager PL, Vaalburg W, Pruim J, de Vries EG, Langen KJ, Piers DA. Radiolabeled amino acids: basic aspects and clinical applications in oncology. J Nucl Med 2001; 42:432-445.
6. Cook GJR, Maisey MN, Fogelman I. Normal variants, artefacts and interpretative pitfalls in PET imaging with 18-fluoro-2-deoxyglucose and carbon-11 methionine. Eur J Nucl Med 1999; 26:1363-1378.
7. 11C-methionine PET/CT in 99mTc-sestamibi-negative hyperparathyroidism in patients with renal failure on chronic haemodialysis. Eur J Nucl Med Mol Imaging 2006; 33:453-459.
8. 3/KF. Appl Radiat Isot 1995; 46:893-897.
9. 11C]methylation on C18 Sep-Pak. J Labelled Comp Radiopharm 1999; 42:715-724.
10. 11C]choline, a positron-emitting tracer for tumor imaging. Appl Radiat Isot 1999; 50:531-533.
11. 11C]choline. J Labelled Comp Radiopharm 2000; 43:195-203.
12. 11C]choline for multi dose utilization. Appl Radiat Isot 2004; 60:835-838.
13. 11C]methionine: a simple and fast online approach without preparative HPLC. Appl Radiat Isot 2005; 62:441-445.
14. 11C-labeled tracers by solid supported methylation. Appl Radiat Isot 2006; 64:808-811.
15. 11C]carboxylation. Appl Radiat Isot 2007; 65:691-695.