Highly efficient automated synthesis of [11C]choline for multi dose utilization

Applied Radiation and Isotopes

Volumn 60, Issue 6, 2004, Pages 835-838

  Reischl, G ^a   Bieg, C ^a   Schmiedl, O ^a   Solbach, C ^a   Machulla, H J ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

11C Choline; Loop method; PET; Prostate cancer; Solvent free methylation

Indexed keywords

ION EXCHANGE; OPTIMIZATION; POSITIVE IONS; SYNTHESIS (CHEMICAL); TUMORS;

PROSTATE CANCER; RADIOCHEMICALS;

RADIOISOTOPES;

CARBON 11; CHOLINE; DIMETHYLAMINE; SOLVENT; TRACER;

ARTICLE; CHEMICAL REACTION KINETICS; DRUG PURIFICATION; ION EXCHANGE; PRIORITY JOURNAL; RADIATION DOSE; RADIOCHEMISTRY; ROOM TEMPERATURE; SYNTHESIS;

AUTOMATION; CARBON ISOTOPES; CHOLINE; HUMANS; INDICATORS AND REAGENTS; ISOTOPE LABELING; MALE; PROSTATIC NEOPLASMS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 1942501193     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2004.01.006     Document Type: Article

References (19)

1. 11C-methyl]betaine. J. Label. Compd. Radiopharm. 44:2001;S107-S109
2. 11C-choline PET. first clinical experience Eur. J. Nucl. Med. 29:2002;1283-1288
3. 11C-choline PET. J. Nucl. Med. 44:2003;331-335
4. 11C]choline, a positron-emitting tracer for tumor imaging. Appl. Radiat. Isot. 50:1999;531-533
5. 11C]choline. J. Nucl. Med. 38:1997;842-847
6. Hara T., Kosaka N., Kishi H. PET imaging of prostate cancer using carbon-11-choline. J. Nucl. Med. 39:1998;990-995
7. 11C-choline PET. J. Nucl. Med. 41:2000;1507-1513
8. 11C] doxepin. J. Label. Compd. Radiopharm. 45:2002;271-280
9. Jager P.L., Que T.H., Vaalburg W., Pruim J., Elsinga P., Plukker J.T. Carbon-11 choline or FDG-PET for staging of oesophageal cancer. Eur. J. Nucl. Med. 28:2001;1845-1849
10. Kotzerke J., Prang J., Neumaier B., Volkmer B., Guhlmann A., Kleinschmidt K., Hautmann R., Reske S.N. Experience with carbon-11 choline positron emission tomography in prostate carcinoma. Eur. J. Nucl. Med. 27:2000;1415-1419
11. Kotzerke J., Geschwend J.E., Neumaier B. PET for prostate cancer imaging. still a quandary or the ultimate solution? J. Nucl. Med. 43:2002;200-202
12. 11C]choline. J. Label. Compd. Radiopharm. 42:1999;S480-S482
13. Mishani E., Bocher M., Ben-David I., Rozen Y., Laky D., Marciano R., Chisin R. [C-11]choline - automated preparation and clinical utilization. J. Label. Compd. Radiopharm. 44:2001;S379-S381
14. 11C]choline J. Label. Compd. Radiopharm. 43:2000;195-203
15. 11C]choline; implications for in vivo imaging with positron emission tomography. Eur. J. Nucl. Med. 27:2000;25-32
16. Rosen M.A., Jones R.M., Yano Y., Budinger T.F. Carbon-11 choline. synthesis, purification, and brain uptake inhibition by 2-dimethylaminoethanol J. Nucl. Med. 26:1985;1424-1428
17. Shinoura N., Nishijima M., Hara T., Haisa T., Yamamoto H., Fujii K., Mitsui I., Kosaka N., Kondo T., Hara T. Brain tumors. detection with C-11 choline PET Radiology. 202:1997;497-503
18. 11C]carfentanil. J. Label. Compd. Radiopharm. 46:2003;837-842
19. 11C]-iodomethane. a remarkably simple captive solvent method Nucl. Med. Biol. 27:2000;529-532