Targeting the retinoblastoma protein by MC007L, gene product of the molluscum contagiosum virus: Detection of a novel virus-cell interaction by a member of the poxviruses

Journal of Virology

Volumn 82, Issue 21, 2008, Pages 10625-10633

  Mohr, Stefan ^a   Grandemange, Stéphanie ^b   Massimi, Paola ^c   Darai, Gholamreza ^a   Banks, Lawrence ^c   Martinou, Jean Claude ^b   Zeier, Martin ^a   Muranyi, Walter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN MC007L; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; ONCOPROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MOLLUSCIPOXVIRUS; NONHUMAN; POXVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VIRUS CELL INTERACTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF;

DNA VIRUSES; MOLLUSCUM CONTAGIOSUM VIRUS; POXVIRIDAE; RATTUS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CONSERVED SEQUENCE; HUMANS; MITOCHONDRIAL MEMBRANES; MOLECULAR SEQUENCE DATA; MOLLUSCUM CONTAGIOSUM VIRUS; ONCOGENE PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RATS; RETINOBLASTOMA PROTEIN; VIRAL PROTEINS;

EID: 55249115616     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01187-08     Document Type: Article

References (43)

1. Bugert, J. J., C. Lohmüller, and G. Darai. 1999. Characterization of early gene transcripts of molluscum contagiosum virus. Virology 257:119-129.
2. Bugert, J. J., N. Melquiot, and R. Kehm. 2001. Molluscum contagiosum virus expresses late genes in primary human fibroblasts but does not produce infectious progeny. Virus Genes 22:27-33.
3. Bugert, J. J., C. Lohmüller, I. Damon, B. Moss, and G. Darai. 1998. Chemokine homolog of molluscum contagiosum virus: sequence conservation and expression. Virology 242:51-59.
4. Campbell, R. E., O. Tour, A. E. Palmer, P. A. Steinbach, G. S. Baird, D. A. Zacharias, and R. Y. Tsien. 2002. A monomeric red fluorescent protein. Proc. Natl. Acad. Sci. USA 99:7877-7882.
5. Chan, H. M., L. Smith, and N. B. La Thangue. 2001. Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein. Oncogene 20:6152-6163.
6. Chellappan, S., V. B. Kraus, B. Kroger, K. Münger, P. M. Howley, W. C. Phelps, and J. R. Nevins. 1992. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. USA 89:4549-4553.
7. Damon, I. K. 2007. Poxviruses, p. 2963-2965. In B. Knipe and D. M. Howley (ed.), Fields virology, 3rd ed., vol. 2. Lippincott Williams & Wilkins, Philadelphia, PA.
8. Dyson, N., P. Guida, K. Münger, and E. Harlow. 1992. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J. Virol. 66:6893-6902.
9. Egan, C., T. N. Jelsma, J. A. Howe, S. T. Bayley, B. Ferguson, and P. E. Branton. 1988. Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5. Mol. Cell. Biol. 8:3955-3959.
10. Epstein, W. L., and K. Fukuyama. 1973. Maturation of molluscum contagiosum virus (MCV) in vivo: quantitative electron microscopic autoradiography. J. Investig. Dermatol. 60:73-79.
11. Everett, H., M. Barry, S. F. Lee, X. Sun, K. Graham, J. Stone, R. C. Bleackley, and G. McFadden. 2000. M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes. J. Exp. Med. 191:1487-1498.
12. Fattaey, A. R., E. Harlow, and K. Helin. 1993. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol. Cell. Biol. 13:7267-7277.
13. Heck, D. V., C. L. Yee, P. M. Howley, and K. Münger. 1992. Efficiency of binding the retinoblastomaprotein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses. Proc. Natl. Acad. Sci. USA 89:4442-4446.
14. Helin, K., E. Harlow, and A. Fattaey. 1993. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 13:6501-6508.
15. Helt, A. M., and D. A. Galloway. 2003. Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. Carcinogenesis 24:159-169.
16. Hu, S., C. Vincenz, M. Buller, and V. M. Dixit. 1997. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis. J. Biol. Chem. 272:9621-9624.
17. Hwang, Y., B. Wang, and F. D. Bushman. 1998. Molluscum contagiosum virus topoisomerase: purification, activities, and response to inhibitors. J. Virol. 72:3401-3406.
18. Ishikawa-Mochizuki, I., M. Kitaura, M. Baba, T. Nakayama, D. Izawa, T. Imai, H. Yamada, K. Hieshima, R. Suzuki, H. Nomiyama, and O. Yoshie. 1999. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. FEBS Lett. 460:544-548.
19. Izu, R., D. Manzano, J. Gardeazabal, and J. L. Diaz-Perez. 1994. Giant molluscum contagiosum presenting as a tumor in an HIV-infected patient. Int. J. Dermatol. 33:266-267.
20. Kanaji, S., J. Iwahashi, Y. Kida, M. Sakaguchi, and K. Mihara. 2000. Characterization of the signal that directs Tom20 to the mitochondrial outer membrane. J. Cell Biol. 151:277-288.
21. Matlashewski, G., J. Schneider, L. Banks, N. Jones, A. Murray, and L. Crawford. 1987. Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells. EMBO J. 6:1741-1746.
22. Murao, L. E., and J. L. Shisler. 2005. The MCV MC159 protein inhibits late, but not early, events of TNF-α-induced NF-κB activation. Virology 340:255-264.
23. Nevins, J. R. 2001. The Rb/E2F pathway and cancer. Hum. Mol. Genet. 10:699-703.
24. Nichols, D. B., and J. L. Shisler. 2006. The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-κB activation via inhibition of I kappa kinase complex formation. J. Virol. 80:578-586.
25. Parone, P. A., D. I. James, S. Da Cruz, Y. Mattenberger, O. Donzé, F. Barja, and J.-C. Martinou. 2006. Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol. Cell. Biol. 26:7397-7408.
26. Patrick, D. R., A. Oliff, and D. C. Heimbrook. 1994. Identification of a novel retinoblastoma gene product binding site on human papillomavirus type 16 E7 protein. J. Biol. Chem. 269:6842-6850.
27. Postlethwaite, R. 1970. Molluscum contagiosum. Arch. Environ. Health 21:432-452.
28. Rapoport, D. 2003. Finding the right organelle. EMBO Rep. 4:948-952.
29. Rogoff, H. A., M. T. Pickering, F. M. Frame, M. E. Debatis, Y. Sanchez, S. Jones, and T. F. Kowalik. 2004. Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol. Cell. Biol. 24:2968-2977.
30. Senkevich, T. G., J. J. Bugert, J. R. Sisler, E. V. Koonin, G. Darai, and B. Moss. 1996. Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes. Science 273:813-816.
31. Senkevich, T. G., E. V. Koonin, J. J. Bugert, G. Darai, and B. Moss. 1997. The genome of molluscum contagiosum virus: analysis and comparison with other poxviruses. Virology 233:19-42.
32. Senkevich, T. G., and B. Moss. 1998. Domain structure, intracellular trafficking, and beta2-microglobulin binding of a major histocompatibility complex class I homolog encoded by molluscum contagiosum virus. Virology 250:397-407.
33. Shisler, J. L., T. G. Senkevich, M. J. Berry, and B. Moss. 1998. Ultraviolet-induced cell death blocked by a selenoprotein from a human dermatotropic poxvirus. Science 279:102-105.
34. Shisler, J. L., and B. Moss. 2001. Molluscum contagiosum virus inhibitors of apoptosis: the MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein. Virology 282:14-25.
35. Simonart, T., I. Fayt, and J. C. Noel. 2002. An immunohistochemical study of abnormal keratinocyte proliferation in molluscum contagiosum. Br. J. Dermatol. 146:609-614.
36. Stewart, T. L., S. T. Wasilenko, and M. Barry. 2005. Vaccinia virus F1L protein is a tail-anchored protein that functions at the mitochondria to inhibit apoptosis. J. Virol. 79:1084-1098.
37. Takahashi, M., A. Izutani, and T. Tezuka. 1999. An immunohistochemical study of abnormal keratinocyte differentiation in molluscum contagiosum. Br. J. Dermatol. 141:116-118.
38. Verona, R., K. Moberg, S. Estes, M. Starz, J. P. Vernon, and J. A. Lees. 1997. E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol. Cell. Biol. 17:7268-7282.
39. Wasilenko, S. T., T. L. Stewart, A. F. Meyers, and M. Barry. 2003. Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis. Proc. Natl. Acad. Sci. USA 100:14345-14350.
40. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
41. Whyte, P., N. M. Williamson, and E. Harlow. 1989. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75.
42. Xiang, Y., and B. Moss. 1999. Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus. Virology 257:297-302.
43. Ziegler, H., W. Muranyi, H. G. Burgert, E. Kremmer, and U. H. Koszinowski. 2000. The luminal part of the murine cytomegalovirus glycoprotein gp40 catalyzes the retention of MHC class I molecules. EMBO J. 19:870-881.