Variations in prostate-specific antigen free/total ratio in acute stress

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 68, Issue 7, 2008, Pages 624-627

  Mahfouz, Rami A ^a   Cortas, Najwa K ^a   Ibrahim, George ^a   Khalife, Simon ^a   Daher, Rose T ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Alpha2 macroglobulin; C reactive protein; Operative stress; Prostate cancer; Prostate specific antigen

Indexed keywords

ALBUMIN; ALPHA 2 MACROGLOBULIN; C REACTIVE PROTEIN; PROSTATE SPECIFIC ANTIGEN;

ACUTE STRESS; ADULT; AGED; ANTIGENIC VARIATION; ARTICLE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CORONARY ARTERY BYPASS GRAFT; CORRELATION ANALYSIS; DATA ANALYSIS; HUMAN; INFORMATION; MEASUREMENT; NEPHELOMETRY; PLASMA VOLUME; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; SURGICAL STRESS; TURBIDIMETRY;

AGED; ALPHA-MACROGLOBULINS; C-REACTIVE PROTEIN; CORONARY ARTERY BYPASS; HUMANS; MALE; MIDDLE AGED; PROSTATE-SPECIFIC ANTIGEN; STRESS, PHYSIOLOGICAL; SURGICAL PROCEDURES, OPERATIVE;

EID: 55249113471     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510801993251     Document Type: Article

References (17)

1. Lilja H, Christensson A, Dahlén U, Matikainen M-T, Nilsson O, Pettersson K. Prostate-specific antigen in serum occurs predominantly in complex with a1-antichymotrypsin. Clin Chem 1991;37:1618-25.
2. Noldus J, Chen Z, Stamey TA. Isolation and characterization of free form prostate specific antigen (f-PSA) in sera of men with prostate cancer. J Urol 1997;158:1606-9.
3. Stenman UH, Leinonen J, Alfthan H, Rannikko S, Tuhkanen K, Alfthan O. A complex between prostate-specific antigen and a1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostate cancer: assay of the complex improves clinical sensitivity for cancer. Cancer Res 1991;51:222-6.
4. Zhang WM, Leinonen J, Kalkkinen N, Dowell B, Stenman UH. Purification and characterization of different molecular forms of prostate-specific antigen in human seminal fluid. Clin Chem 1995;41:1567-73.
5. Christensson A, Laurell CB, Lilja H. Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors. Eur J Biochem 1990;194:755-63.
6. Christensson A, Lilja H. Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen. Eur J Biochem 1994;220:45-53.
7. 2 macroglobulin. Clin Chem 1998;44:2471-9.
8. Otto A, Bär J, Birkenmeier G. Prostate-specific antigen forms complexes with human α2-macroglobulin and binds to the α2-macroglobulin receptor/LDL receptor-related protein. J Urol 1998;159:297-303.
9. Leinonen J, Zhang WM, Stenamn UH. Complex formation between PSA isoenzymes and protease inhibitors. J Urol 1996;155:1099-103.
10. Honda SAA, Goldstein AP, Morita T, Sugiyama C, Cody L, Rios CN, et al. Prostate-specific antigen concentrations in serum in acute illnesses. Clin Chem 1996;42:1785-8.
11. Lennard TWJ, Shenton BK, Borzotta A, Donnelly PK, White M, Gerrie LM, et al. The influence of surgical operations on components of the human immune system. Br J Surg 1985;72:771-6.
12. Meyer A, Jung K, Lein M, Rudolph B, Schnorr D, Loening SA. Factors influencing the ratio of free to total prostate-specific antigen in serum. Int J Cancer 1997;74:630-6.
13. Kotyza J. Proteases and antiproteases in health and disease a review - IV. Alpha-2-macroglobulin. Biomark Environ 2002;5:1-13.
14. Lilja H, Haese A, Björk T, Friedrich MG, Piironen T, Pettersson K, et al. Significance and metabolism of complexed and noncomplexed prostate specific antigen forms, and human glandular kallikrein 2 in clinically localized prostate cancer before and after radical prostatectomy. J Urol 1999;162:2029-35.
15. Zhang WM, Finne P, Leinonen J, Salo J, Stenman U-H. Determination of prostate-specific antigen complexed to alpha2-macroglobulin in serum increases the specificity of free to total PSA for prostate cancer. Urology 2000;56:267-72.
16. Brandle E, Hautmann O, Bachem M, Kleinschmidt K, Gottfried HW, Grünert A, et al. Serum half-life time determination of free and total prostate-specific antigen following radical prostatectomy - a critical assessment. Urology 1999;53:722-30.
17. Kao PC, Shiesh S-C, Wu T-J. Serum C-reactive protein as a marker for wellness assessment. Ann Clin Lab Sci 2006;36:63-9.