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1
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10444278109
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Spatial analysis of the distribution of intestinal nematode infections in Uganda
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Brooker S, Kabatereine NB, Tukahebwa EM, Kazibwe F. Spatial analysis of the distribution of intestinal nematode infections in Uganda. Epidemiol Infect 2004; 132:1065-1071.
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Epidemiol Infect
, vol.132
, pp. 1065-1071
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Brooker, S.1
Kabatereine, N.B.2
Tukahebwa, E.M.3
Kazibwe, F.4
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2
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10444278109
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Spatial analysis of the distribution of intestinal nematode infections in Uganda
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Brooker S, Kabatereine NB, Tukahebwa EM, Kazibwe F. Spatial analysis of the distribution of intestinal nematode infections in Uganda. Epidemiol Infect 2004; 132:1065-1071.
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(2004)
Epidemiol Infect
, vol.132
, pp. 1065-1071
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Brooker, S.1
Kabatereine, N.B.2
Tukahebwa, E.M.3
Kazibwe, F.4
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3
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39349096914
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Williams-Blangero S, VandeBerg JL, Subedi J, et al. Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. J Infect Dis 2008; 197:66-71. This and the following article are among the first genome-wide linkage scans for infectious diseases. Detailed pedigree analysis in this isolated community previously allowed researchers to attribute 30-50% worm burden to genetics.
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Williams-Blangero S, VandeBerg JL, Subedi J, et al. Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. J Infect Dis 2008; 197:66-71. This and the following article are among the first genome-wide linkage scans for infectious diseases. Detailed pedigree analysis in this isolated community previously allowed researchers to attribute 30-50% worm burden to genetics.
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4
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42549158073
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Two quantitative trait loci influence whipworm (Trichuris trichiura) infection in a Nepalese population
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Williams-Blangero S, VandeBerg JL, Subedi J, et al. Two quantitative trait loci influence whipworm (Trichuris trichiura) infection in a Nepalese population. J Infect Dis 2008; 197:1198-1203.
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J Infect Dis
, vol.197
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Williams-Blangero, S.1
VandeBerg, J.L.2
Subedi, J.3
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5
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33644904626
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Synergistic associations between hookworm and other helminth species in a rural community in Brazil
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Fleming FM, Brooker S, Geiger SM, et al. Synergistic associations between hookworm and other helminth species in a rural community in Brazil. Trop Med Int Health 2006; 11:56-64.
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Trop Med Int Health
, vol.11
, pp. 56-64
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Fleming, F.M.1
Brooker, S.2
Geiger, S.M.3
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6
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34247177418
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Moderate- and low-intensity co-infections by intestinal helminths and Schistosoma mansoni, dietary iron intake, and anemia in Brazilian children
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Brito LL, Barreto ML, Silva Rde C, et al. Moderate- and low-intensity co-infections by intestinal helminths and Schistosoma mansoni, dietary iron intake, and anemia in Brazilian children. Am J Trop Med Hyg 2006; 75:939-944.
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Am J Trop Med Hyg
, vol.75
, pp. 939-944
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Brito, L.L.1
Barreto, M.L.2
Silva Rde, C.3
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7
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38049069827
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Ndyomugyenyi R, Kabatereine N, Olsen A, Magnussen P. Malaria and hookworm infections in relation to haemoglobin and serum ferritin levels in pregnancy in Masindi district, western Uganda. Trans R Soc Trop Med Hyg 2008; 102:130-136. This observational antenatal clinic survey from an area hyperendemic for malaria demonstrated the fraction attributable for anaemia of hookworm (28.5%) and malaria (22.6%). Although Ascaris and Trichuris independently predicted serum ferritin levels, only hookworm predicted haemoglobin levels.
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Ndyomugyenyi R, Kabatereine N, Olsen A, Magnussen P. Malaria and hookworm infections in relation to haemoglobin and serum ferritin levels in pregnancy in Masindi district, western Uganda. Trans R Soc Trop Med Hyg 2008; 102:130-136. This observational antenatal clinic survey from an area hyperendemic for malaria demonstrated the fraction attributable for anaemia of hookworm (28.5%) and malaria (22.6%). Although Ascaris and Trichuris independently predicted serum ferritin levels, only hookworm predicted haemoglobin levels.
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8
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34447621582
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Associations between mild-tomoderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda
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Among semi-urban pregnant women booking in a Ugandan antenatal clinic, fractions attributable for anaemia were hookworm (3.1, malaria (12.3, and HIV 10.2, Baseline nutritional status was good and may be an important consideration
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Muhangi L, Woodburn P, Omara M, et al. Associations between mild-tomoderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda. Trans R Soc Trop Med Hyg 2007; 101:899-907. Among semi-urban pregnant women booking in a Ugandan antenatal clinic, fractions attributable for anaemia were hookworm (3.1%), malaria (12.3%) and HIV (10.2%). Baseline nutritional status was good and may be an important consideration.
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(2007)
Trans R Soc Trop Med Hyg
, vol.101
, pp. 899-907
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Muhangi, L.1
Woodburn, P.2
Omara, M.3
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9
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35148856129
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Long KZ, Rosado JL, Montoya Y, et al. Effect of vitamin A and zinc supplementation on gastrointestinal parasitic infections among Mexican children. Pediatrics 2007; 120:e846-e855. This randomized factorial-designed placebo-controlled trial of vitamin A and zinc in Mexican infants explored incidence of A. lumbricoides, Entamoeba histolytica and Giardia lamblia in the 12 months after treatment. Zinc supplementation was associated with an increased incidence of A. lumbricoides.
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Long KZ, Rosado JL, Montoya Y, et al. Effect of vitamin A and zinc supplementation on gastrointestinal parasitic infections among Mexican children. Pediatrics 2007; 120:e846-e855. This randomized factorial-designed placebo-controlled trial of vitamin A and zinc in Mexican infants explored incidence of A. lumbricoides, Entamoeba histolytica and Giardia lamblia in the 12 months after treatment. Zinc supplementation was associated with an increased incidence of A. lumbricoides.
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10
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34248546255
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Maltreatment of Strongyloides infection: Case series and worldwide physicians-in-training survey
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This questionnaire-based survey demonstrated poor knowledge of the clinical features of strongyloidiasis, an important parasite to recognize in migrants as it can persist for decades after exposure
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Boulware DR, Stauffer WM, Hendel-Paterson BR, et al. Maltreatment of Strongyloides infection: case series and worldwide physicians-in-training survey. Am J Med 2007; 120:545 e1-8. This questionnaire-based survey demonstrated poor knowledge of the clinical features of strongyloidiasis - an important parasite to recognize in migrants as it can persist for decades after exposure.
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(2007)
Am J Med
, vol.120
, Issue.545
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Boulware, D.R.1
Stauffer, W.M.2
Hendel-Paterson, B.R.3
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11
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48749099261
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A luciferase immunoprecipitation systems assay enhances the sensitivity and specificity of diagnosis of Strongyloides stercoralis infection
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Ramanathan R, Burbelo PD, Groot S, et al. A luciferase immunoprecipitation systems assay enhances the sensitivity and specificity of diagnosis of Strongyloides stercoralis infection. J Infect Dis 2008; 198:444-451.
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(2008)
J Infect Dis
, vol.198
, pp. 444-451
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Ramanathan, R.1
Burbelo, P.D.2
Groot, S.3
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12
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34249828202
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Gulani A, Nagpal J, Osmond C, Sachdev HP. Effect of administration of intestinal anthelmintic drugs on haemoglobin: systematic review of randomised controlled trials. BMJ 2007; 334:1095. This meta-analysis demonstrated a marginal increase in haemoglobin afforded by antihelminth therapy. Most studies were in preschool and school-age children in Africa. Baseline iron status and intake were not recorded.
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Gulani A, Nagpal J, Osmond C, Sachdev HP. Effect of administration of intestinal anthelmintic drugs on haemoglobin: systematic review of randomised controlled trials. BMJ 2007; 334:1095. This meta-analysis demonstrated a marginal increase in haemoglobin afforded by antihelminth therapy. Most studies were in preschool and school-age children in Africa. Baseline iron status and intake were not recorded.
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13
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34249814324
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Intestinal nematode infection and anaemia in developing countries
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Awasthi S, Bundy D. Intestinal nematode infection and anaemia in developing countries. BMJ 2007; 334:1065-1066.
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BMJ
, vol.334
, pp. 1065-1066
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Awasthi, S.1
Bundy, D.2
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14
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33751526706
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Brooker S, Jardim-Botelho A, Quinnell RJ, et al. Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil. Trans R Soc Trop Med Hyg 2007; 101:146-154. This cross-sectional household survey explored associations with socioeconomic status, nutrition, iron deficiency and anaemia. Hookworm prevalence and intensity were highest in poorer individuals but socioeconomic status had no effect on the relationship of hookworm with anaemia. Hookworm made no significant contribution to anaemia in preschool children.
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Brooker S, Jardim-Botelho A, Quinnell RJ, et al. Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil. Trans R Soc Trop Med Hyg 2007; 101:146-154. This cross-sectional household survey explored associations with socioeconomic status, nutrition, iron deficiency and anaemia. Hookworm prevalence and intensity were highest in poorer individuals but socioeconomic status had no effect on the relationship of hookworm with anaemia. Hookworm made no significant contribution to anaemia in preschool children.
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15
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40049097142
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Epidemiology of plasmodium-helminth co-infection in Africa: Populations at risk, potential impact on anemia, and prospects for combining control
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Brooker S, Akhwale W, Pullan R, et al. Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining control. Am J Trop Med Hyg 2007; 77:88-98.
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Am J Trop Med Hyg
, vol.77
, pp. 88-98
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Brooker, S.1
Akhwale, W.2
Pullan, R.3
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16
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44949157909
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Taylor-Robinson DC, Jones AP, Garner P. Deworming drugs for treating soiltransmitted intestinal worms in children: effects on growth and school performance. Cochrane Database Syst Rev 2007:CD000371. This analysis is important in addressing the evidence that supports deworming policies to improve growth and school performance. There was a significant gain in weight, but not height, and no conclusive evidence for an impact on school performance or cognition. The 34 studies were in health centres, schools, and the community, the majority from areas of high-helminth prevalence and intensity.
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Taylor-Robinson DC, Jones AP, Garner P. Deworming drugs for treating soiltransmitted intestinal worms in children: effects on growth and school performance. Cochrane Database Syst Rev 2007:CD000371. This analysis is important in addressing the evidence that supports deworming policies to improve growth and school performance. There was a significant gain in weight, but not height, and no conclusive evidence for an impact on school performance or cognition. The 34 studies were in health centres, schools, and the community, the majority from areas of high-helminth prevalence and intensity.
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18
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34250304648
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Mass iron treatment is cheaper than routine deworming
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Kapoor S. Mass iron treatment is cheaper than routine deworming. BMJ 2007; 334:1180.
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(2007)
BMJ
, vol.334
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Kapoor, S.1
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19
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33749025546
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A double-blind randomized controlled trial of antenatal mebendazole to reduce low birth weight in a hookworm-endemic area of Peru
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Larocque R, Casapia M, Gotuzzo E, et al. A double-blind randomized controlled trial of antenatal mebendazole to reduce low birth weight in a hookworm-endemic area of Peru. Trop Med Int Health 2006; 11:1485-1495.
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Trop Med Int Health
, vol.11
, pp. 1485-1495
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Larocque, R.1
Casapia, M.2
Gotuzzo, E.3
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20
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33646173617
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Schistosomiasis and soil-transmitted helminth infections: Preliminary estimates of the number of children treated with albendazole or mebendazole
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World Health Organisation
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World Health Organisation. Schistosomiasis and soil-transmitted helminth infections: preliminary estimates of the number of children treated with albendazole or mebendazole. Wkly Epidemiol Rec 2006; 81:145-163.
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Wkly Epidemiol Rec
, vol.81
, pp. 145-163
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Zhang Y, Koukounari A, Kabatereine N, et al. Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda. BMC Med 2007; 5:27. This evaluation after two annual rounds of a national programme demonstrated markedly reduced prevalence even in the youngest children who had not been previously been treated, suggesting an impact on transmission.
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Zhang Y, Koukounari A, Kabatereine N, et al. Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda. BMC Med 2007; 5:27. This evaluation after two annual rounds of a national programme demonstrated markedly reduced prevalence even in the youngest children who had not been previously been treated, suggesting an impact on transmission.
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33846818674
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Kabatereine NB, Brooker S, Koukounari A, et al. Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren. Bull World Health Organ 2007; 85:91-99. Integrated control of S. mansoni and hookworm in schoolchildren resulted in a 0.3 g/dl mean haemoglobin rise after 2 years.
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Kabatereine NB, Brooker S, Koukounari A, et al. Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren. Bull World Health Organ 2007; 85:91-99. Integrated control of S. mansoni and hookworm in schoolchildren resulted in a 0.3 g/dl mean haemoglobin rise after 2 years.
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0034883446
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Evaluation of efficacy of schoolbased anthelmintic treatments against anaemia in children in the United Republic of Tanzania
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Guyatt HL, Brooker S, Kihamia CM, et al. Evaluation of efficacy of schoolbased anthelmintic treatments against anaemia in children in the United Republic of Tanzania. Bull World Health Organ 2001; 79:695-703.
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Bull World Health Organ
, vol.79
, pp. 695-703
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Guyatt, H.L.1
Brooker, S.2
Kihamia, C.M.3
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24
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48949118042
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Effects of deworming on malnourished preschool children in India: An open-labelled, cluster-randomized trial
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In a preschool population with high Ascaris prevalence, albendazole and vitamin A delivered through a regional programme had a substantial impact on weight gain
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Awasthi S, Peto R, Pande VK, et al. Effects of deworming on malnourished preschool children in India: an open-labelled, cluster-randomized trial. PLoS Negl Trop Dis 2008; 2:e223. In a preschool population with high Ascaris prevalence, albendazole and vitamin A delivered through a regional programme had a substantial impact on weight gain.
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(2008)
PLoS Negl Trop Dis
, vol.2
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Awasthi, S.1
Peto, R.2
Pande, V.K.3
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25
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48949118019
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Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy
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Albonico M, Allen H, Chitsulo L, et al. Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. PLoS Negl Trop Dis 2008; 2:e126.
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PLoS Negl Trop Dis
, vol.2
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Albonico, M.1
Allen, H.2
Chitsulo, L.3
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26
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Micronutrient supplements for children after deworming
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Hall A. Micronutrient supplements for children after deworming. Lancet Infect Dis 2007; 7:297-302.
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Lancet Infect Dis
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, pp. 297-302
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Hall, A.1
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27
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42449084148
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Efficacy of current drugs against soil-transmitted helminth infections: Systematic review and meta-analysis
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This meta-analysis supports the use of single dose albendazole as the most efficacious strategy for mass treatment, particularly where hookworm is prevalent
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Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 2008; 299:1937-1948. This meta-analysis supports the use of single dose albendazole as the most efficacious strategy for mass treatment, particularly where hookworm is prevalent.
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JAMA
, vol.299
, pp. 1937-1948
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Keiser, J.1
Utzinger, J.2
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28
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34249732500
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Low efficacy of mebendazole against hookworm in Vietnam: Two randomized controlled trials
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Flohr C, Tuyen LN, Lewis S, et al. Low efficacy of mebendazole against hookworm in Vietnam: two randomized controlled trials. Am J Trop Med Hyg 2007; 76:732-736.
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Am J Trop Med Hyg
, vol.76
, pp. 732-736
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Flohr, C.1
Tuyen, L.N.2
Lewis, S.3
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29
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0036816615
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Soil-transmitted nematode infections and mebendazole treatment in Mafia Island schoolchildren
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Albonico M, Ramsan M, Wright V, et al. Soil-transmitted nematode infections and mebendazole treatment in Mafia Island schoolchildren. Ann Trop Med Parasitol 2002; 96:717-726.
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Ann Trop Med Parasitol
, vol.96
, pp. 717-726
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Albonico, M.1
Ramsan, M.2
Wright, V.3
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30
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19544385793
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Development of the egg hatch assay for detection of anthelminthic resistance in human hookworms
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Albonico M, Wright V, Ramsan M, et al. Development of the egg hatch assay for detection of anthelminthic resistance in human hookworms. Int J Parasitol 2005; 35:803-811.
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Int J Parasitol
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Ramsan, M.3
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1542315322
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Molecular analysis of the beta-tubulin gene of human hookworms as a basis for possible benzimidazole resistance on Pemba Island
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Albonico M, Wright V, Bickle Q. Molecular analysis of the beta-tubulin gene of human hookworms as a basis for possible benzimidazole resistance on Pemba Island. Mol Biochem Parasitol 2004; 134:281-284.
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Mol Biochem Parasitol
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Albonico, M.1
Wright, V.2
Bickle, Q.3
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32
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35348981195
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Characterization of beta-tubulin genes in hookworms and investigation of resistance- associated mutations using real-time PCR
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Despite strong genetic similarities between animal and human hookworms, this molecular study did not demonstrate in human isolates the well characterized polymorphisms associated with resistance in veterinary practice
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Schwenkenbecher JM, Albonico M, Bickle Q, Kaplan RM. Characterization of beta-tubulin genes in hookworms and investigation of resistance- associated mutations using real-time PCR. Mol Biochem Parasitol 2007; 156:167-174. Despite strong genetic similarities between animal and human hookworms, this molecular study did not demonstrate in human isolates the well characterized polymorphisms associated with resistance in veterinary practice.
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Mol Biochem Parasitol
, vol.156
, pp. 167-174
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Schwenkenbecher, J.M.1
Albonico, M.2
Bickle, Q.3
Kaplan, R.M.4
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0036327273
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Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru
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Juan JO, Lopez Chegne N, Gargala G, Favennec L. Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru. Trans R Soc Trop Med Hyg 2002; 96:193-196.
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Trans R Soc Trop Med Hyg
, vol.96
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Juan, J.O.1
Lopez Chegne, N.2
Gargala, G.3
Favennec, L.4
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34
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43849101262
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A randomized, double-blind, multicenter clinical trial on the efficacy of ivermectin against intestinal nematode infections in China
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Drugs used in other helminth control programmes, such as ivermectin for lymphatic filariasis, will have an impact on intestinal nematodes but may not be sufficiently active against hookworm or Trichuris
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Wen LY, Yan XL, Sun FH, et al. A randomized, double-blind, multicenter clinical trial on the efficacy of ivermectin against intestinal nematode infections in China. Acta Trop 2008; 106:190-194. Drugs used in other helminth control programmes, such as ivermectin for lymphatic filariasis, will have an impact on intestinal nematodes but may not be sufficiently active against hookworm or Trichuris.
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(2008)
Acta Trop
, vol.106
, pp. 190-194
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Wen, L.Y.1
Yan, X.L.2
Sun, F.H.3
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35
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Tribendimidine: A promising, safe and broad-spectrum anthelmintic agent from China
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Xiao SH, Hui-Ming W, Tanner M, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop 2005; 94:1-14.
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Acta Trop
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Xiao, S.H.1
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Xiao SH, Wu ZX, Zhang JH, et al. Clinical observation on 899 children infected with intestinal nematodes and treated with tribendimidine enteric coated tablets. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2007; 25:372-375. The epidemiological evidence and potential biological mechanisms have been sufficiently rehearsed to justify a clinical trial of deliberate hookworm infection to treat asthma. A dose-ranging study has been published demonstrating patent infection and eosinophilia with 10 larvae
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Xiao SH, Wu ZX, Zhang JH, et al. Clinical observation on 899 children infected with intestinal nematodes and treated with tribendimidine enteric coated tablets. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2007; 25:372-375. The epidemiological evidence and potential biological mechanisms have been sufficiently rehearsed to justify a clinical trial of deliberate hookworm infection to treat asthma. A dose-ranging study has been published demonstrating patent infection and eosinophilia with 10 larvae
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40749099893
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A new class of anthelmintics effective against drug-resistant nematodes
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Widespread resistance to benzimidazoles in livestock raises concerns that resistance will develop in humans; the development of new drugs is encouraging
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Kaminsky R, Ducray P, Jung M, et al. A new class of anthelmintics effective against drug-resistant nematodes. Nature 2008; 452:176-180. Widespread resistance to benzimidazoles in livestock raises concerns that resistance will develop in humans; the development of new drugs is encouraging.
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Nature
, vol.452
, pp. 176-180
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Kaminsky, R.1
Ducray, P.2
Jung, M.3
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36549069120
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Utzinger J, Rinaldi L, Lohourignon LK, et al. FLOTAC: a new sensitive technique for the diagnosis of hookworm infections in humans. Trans R Soc Trop Med Hyg 2008; 102:84-90. This new technique shows promise as an important new tool for individual hookworm diagnosis and for rigorous monitoring of helminth control programmes.
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Utzinger J, Rinaldi L, Lohourignon LK, et al. FLOTAC: a new sensitive technique for the diagnosis of hookworm infections in humans. Trans R Soc Trop Med Hyg 2008; 102:84-90. This new technique shows promise as an important new tool for individual hookworm diagnosis and for rigorous monitoring of helminth control programmes.
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33751544007
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Dacombe RJ, Crampin AC, Floyd S, et al. Time delays between patient and laboratory selectively affect accuracy of helminth diagnosis. Trans R Soc Trop Med Hyg 2007; 101:140-145. This careful study demonstrates the remarkable hourly attrition in diagnostic sensitivity of standard parasitological methods with delays in laboratory processing, and is of great relevance to future field studies.
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Dacombe RJ, Crampin AC, Floyd S, et al. Time delays between patient and laboratory selectively affect accuracy of helminth diagnosis. Trans R Soc Trop Med Hyg 2007; 101:140-145. This careful study demonstrates the remarkable hourly attrition in diagnostic sensitivity of standard parasitological methods with delays in laboratory processing, and is of great relevance to future field studies.
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40
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42649132461
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Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 Hookworm Vaccine in unexposed adults
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This first phase I trial of a human hookworm vaccine demonstrates that the candidate vaccine induces a prolonged immune response in adults not exposed to hookworm
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Bethony JM, Simon G, Diemert DJ, et al. Randomized, placebo-controlled, double-blind trial of the Na-ASP-2 Hookworm Vaccine in unexposed adults. Vaccine 2008; 26:2408-2417. This first phase I trial of a human hookworm vaccine demonstrates that the candidate vaccine induces a prolonged immune response in adults not exposed to hookworm.
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Vaccine
, vol.26
, pp. 2408-2417
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Bethony, J.M.1
Simon, G.2
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Sabatelli L, Ghani AC, Rodrigues LC, et al. Modelling heterogeneity and the impact of chemotherapy and vaccination against human hookworm. J R Soc Interface 2008; 10 Mar [Epub ahead of print].
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Sabatelli L, Ghani AC, Rodrigues LC, et al. Modelling heterogeneity and the impact of chemotherapy and vaccination against human hookworm. J R Soc Interface 2008; 10 Mar [Epub ahead of print].
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Immune dysregulation in Ethiopian immigrants in Israel: Relevance to helminth infections?
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Bentwich Z, Weisman Z, Moroz C, et al. Immune dysregulation in Ethiopian immigrants in Israel: relevance to helminth infections? Clin Exp Immunol 1996; 103:239-243.
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