Environmental exposure to platinum group elements released by automotive catalytic converters: The risk for children

International Journal of Environment and Health

Volumn 2, Issue 3-4, 2008, Pages 439-462

  Conti, Marcelo Enrique ^a   Alimonti, Alessandro ^b   Bocca, Beatrice ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Catalyst; Children; PGEs; Platinum group elements; Urban exposure

Indexed keywords

EID: 55249107224     PISSN: 17434955     EISSN: 17434963     Source Type: Journal    
DOI: 10.1504/IJENVH.2008.020935     Document Type: Article

References (118)

1. Alimonti, A., Petrucci, F., Krachler, M., Bocca, B. and Caroli, S. (2000) 'Reference values for chromium, nickel and vanadium in urine of youngsters from the urban area of Rome', Journal of Environmental Monitoring, Vol. 2, pp.351-354.
2. Alt, F., Bambauer, A., Hoppstock, K., Mergler, B. and Tölg, G. (1993) 'Platinum traces in airborne particulate matter. Determination of whole content, particle size distribution and soluble platinum', Fresenius' Journal of Analytical Chemistry, Vol. 346, pp.693-696.
3. Alt, F., Eschnauer, H.R., Mergler, B., Messerschmidt, J. and Tölg, G. (1997) 'A contribution to the ecology and enology of platinum'. Fresenius' Journal of Analytical Chemistry, Vol. 357, pp.1013-1019.
4. Artelt, S., Creutzenberg, O., Kock, H., Levsena, K., Nachtigall, D., Heinrich, U., Ruhle, T. and Schlogl, R. (1999a) 'Bioavailability of fine dispersed platinum as emitted from automotive catalytic converters: A model study', Science of the Total Environment, Vol. 228, pp.219-242.
5. Artelt, S., Kock, H., König, H.P., Levsen, K. and Rosner, G. (1999b) 'Engine dynamometer experiments: Platinum emissions from differently aged three-way catalytic converters'. Atmospheric Environment, Vol. 33, pp.3559-3567.
6. Artelt, S., Levsen, K., König, H.P. and Rosner, G. (2000) 'Engine test bench experiments to determine platinum emission from three-way catalytic converters', in Zereini, F. and Alt, F. (Eds): Anthropogenic Platinum-Group Element Emissions. Their Impact on Man and Environment, Springer-Verlag, Berlin, pp.33-44.
7. Bárány, E., Bergdahl, I.A., Bratteby, L.E., Lundh, T., Samuelson, G., Schütz, A., Skerfving, S. and Oskarsson, A. (2002a) 'Relationships between trace element concentrations in human blood and serum'. Toxicological Letters, Vol. 134, pp.177-184.
8. Bárány, E., Bergdahl, I.A., Bratteby, L.E., Lundh, T., Samuelson, G., Schütz, A., Skerfving, S. and Oskarsson, A. (2002b) 'Trace element levels in whole blood and serum of Swedish adolescents'. Science of the Total Environment, Vol. 2886, pp.129-141.
9. Barbante, C., Veysseyre, A., Ferrari, C., Van de Velde, K., Morel, C., Capodaglio, G., Cescon, P., Scarponi, G. and Boutron, C. (2001) 'Greenland snow evidence of large scale atmospheric contamination for platinum, palladium and rhodium'. Environmental Science and Technology, Vol. 35, pp.835-839.
10. Bateson, T.F. and Schwartz, J. (2008) 'Children's response to air pollutants', Journal of Toxicological and Environmental Health A, Vol. 71, pp.238-243.
11. Becker, K., Schulz, C., Kaus, S., Seiwert, M. and Seifert, B. (2003) 'German Environmental Survey 1998 (GerES III): Environmental pollutants in urine of the German population', International Journal of Hygiene and Environmental Health, Vol. 206, pp.15-24.
12. Bedello, P., Goitre, M., Roncarolo, G., Bundino, S. and Cane, D. (1987) 'Contact dermatitis to rhodium'. Contact Dermatitis, Vol. 17, pp.111-112.
13. Begerow, J. and Dunemann, L. (2000) 'Internal platinum and palladium exposure of the general population with emphasis on the exposure from automobile exhaust and dental restorative alloys', in Zereini, F. and Alt, F. (Eds): Anthropogenic Platinum-Group Element Emissions. Their Impact on Man and Environment, Springer-Verlag, Berlin, pp.227-236.
14. Begerow, J., Turfeld, M. and Dunemann, L. (1997a) 'Determination of physiological palladium and platinum levels in urine using double focusing sector field ICP-MS', Fresenius' Journal of Analytical Chemistry, Vol. 359, pp.427-429.
15. Begerow, J., Turfeld, M. and Dunemann, L. (1997b) 'Determination of physiological palladium, platinum, iridium and gold levels in human blood using double focusing sector field inductively coupled plasma mass spectrometry', Journal of Analytical Atomic Spectrometry, Vol. 12, pp.1095-1098.
16. Begerow, J., Wiesmüller, G.A., Turfeld, M. and Dunemann, L. (1998) 'Welchen Beitrag liefern Immissionen aus dem Straßenverkehr zur Hintergrundbelastung der Bevölkerung mit Platin und Palladium?', Umweltmedizin in Forschung und Praxis, Vol. 3, p.257.
17. Benemann, J., Lehmann, N., Bromen, K., Marr, A., Seiwert, M., Schulz, C. and Jöckel, K.H. (2005) 'Assessing contamination paths of the German adult population with gold and platinum. The German Environmental Survey 1998 (GerES III)', International Journal of Hygiene and Environmental Health, Vol. 208, pp.499-508.
18. Bergman, A., Svedberg, U. and Nilsson, E. (1995) 'Contact urticaria with anaphylactic reactions caused by occupational exposure to iridium salt', Contact Dermatitis, Vol. 32, pp.14-17.
19. Bocca, B., Alimonti, A., Cristaudo, A., Cristallini, E., Petrucci, F. and Caroli, S. (2004) 'Monitoring of the exposure to platinum-group elements for two Italian population groups through urine analysis', Analytica Chimica Acta, Vol. 512, pp.19-25.
20. Bocca, B., Petrucci, F., Alimonti, A. and Caroli S. (2003) 'Traffic-related platinum and rhodium concentrations in the atmosphere of Rome', Journal of Environmental Monitoring, Vol. 5, pp.563-568.
21. Boezen, H.M., van der Zee, S.C., Postma, D.S., Vonk, J.M., Gerritsen, J., Hoek, G., Brunekreef, B., Rijcken, B. and Schouten, J.P. (1999) 'Effects of ambient air pollution on upper and lower respiratory symptoms and peak expiratory flow in children', Lancet, Vol. 353, pp.874-878.
22. Botrè, C., Tosi, M., Mazzei, F., Bocca, B., Petrucci, F. and Alimonti, A. (2007) 'Automotive catalytic converters and environmental pollution: Role of the platinum group elements in the redox reactions and free radicals production', International Journal of Environment and Health, Vol. 1, pp.142-152.
23. Brubaker, P.E., Moran, J.P., Bridbord, K. and Hueter, F.G. (1975) 'Noble metals: A toxicological appraisal of potential new environmental contaminants', Environmental Health Perspective, Vol. 10, pp.39-56.
24. Brunekreef, B., Janssen, N.A., de Hartog, J., Harssema, H., Knape, M., van Vliet, P. (1997) 'Air pollution from truck traffic and lung function in children living near motorways', Epidemiology, Vol. 8, pp.298-303.
25. Calverley, A.E., Rees, D. and Dowdeswell, R.J. (1999) 'Allergy to complex salts of platinum in refinery workers: Prospective evaluations of IgE and Phadiatop (R) status', Clinical and Experimental Allergy Vol. 29, pp.703-711.
26. Caroli, S., Alimonti, A., Petrucci, F., Bocca, B., Krachler, M., Forastiere, F., Sacerdote, M.T. and Mallone, S. (2001) 'Assessment of exposure to platinum-group metals in urban children', Spectrochimica Acta B, Vol. 56, pp.1241-1248.
27. Castelain, P.Y. and Castelain, M. (1987) 'Contact-dermatitis to palladium', Contact Dermatitis, Vol. 16, pp.46-46.
28. Clerico, A., Cappelli, C., Ragni, G., Caroli, S., De Ioris, M.A., Sordi, A., Petrucci, F., Bocca, B. and Alimonti, A. (2006) 'Evaluation of carboplatin pharmacokinetics in paediatric oncology by means of inductively coupled plasma mass spectrometry', Annali dell'Istituto Superiore di Sanità, Vol. 42, pp.461-468.
29. Cristaudo, A., Petrucci, F., Sera, F., Forte, G., Violante, N., Senofonte, O., Alimonti, A. and Picardo, M. (2007) 'Clinical and allergological biomonitoring of occupational hypersensitivity to platinum group elements', Analytical Letters, Vol. 40, pp.1-17.
30. Daenen, M., Rogiers, P., Van de Walle, C., Rochette, F., Demedts, M. and Nemery, B. (1999) 'Occupational asthma caused by palladium', European Respiratory Journal, Vol. 13, pp.213-216.
31. de Burbure, C., Buchet, J.P., Leroyer, A., Nisse, C., Haguenoer, J.M., Mutti, A., Smerhovsky, Z., Cikrt, M., Trzcinka-Ochocka, M., Razniewska, G., Jakubowski, M. and Bernard, A. (2006) 'Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: Evidence of early effects and multiple interactions at environmental exposure levels', Environmental Health Perspective, Vol. 114, pp.584-590.
32. de la Cuadra, J., and Grau-Massanés, M. (1991) 'Occupational contact dermatitis from rhodium and cobalt, Contact Dermatitis, Vol. 25, pp. 182-184.
33. Dockery, D.W., Cunningham, J., Damokosh, A.I., Neas, L.M., Spengler, J.D., Koutrakis, P., Ware, J.H. and Speizer, F.E. (1996) 'Health effects of acid aerosols on North American children: Respiratory symptoms', Environmental Health Perspective, Vol. 104, pp.500-505.
34. Dominici, C., Petrucci, F., Caroli, S., Alimonti, A., Clerico, A. and Castello, M. (1989) 'Pharmacokinetic study of high-dose continuous infusion Cisplatin in children with solid tumors', Journal of Clinical Oncology, Vol. 7, pp.100-107.
35. Ducoulombier-Crépineau, C., Feidt, C. and Rychen, G. (2007) 'Platinum and palladium transfer to milk, organs and tissues after a single oral administration to lactating goats', Chemosphere, Vol. 64, pp.712-715.
36. Duffield, F., Vandiver, P., Yoakum, A., Bumgarner, J. and Moran, J. (1976) 'Determination of human body burden baseline data of platinum through autopsy tissue analysis', Environmental Health Perspectives Vol. 15, pp.131-134.
37. Ely, J.C., Neal, C.R., Kulpa, C.F., Schneegurt, M.A., Seidler, J.A. and Jain, J.C. (2001) 'Implications of platinum-group element accumulation along US roads from catalytic-converter attrition', Environmental Science and Technology, Vol. 35, pp.3816-3822.
38. Farago, M.E., Kavanagh, P., Blanks, R., Kelly, J., Kazantzis, G., Thornton, I., Simpson, P.R.J., Cook, M., Delves, H.T. and Hall, G.E.M. (1998) 'Platinum concentrations in urban road dust and soil, and in blood and urine in the United Kingdom', Analyst, Vol. 123, pp.451-454.
39. German Human Biomonitoring Commission (2006) Umweltbundesamtes. Available online at: http://www.umweltbundesamt.de/uba-info-daten-e/ daten-e/monitor/
40. Gómez, B., Gómez, M., Sanchez, J.L., Fernández, R. and Palacios, M.A. (2001) 'Platinum and rhodium in airborne particulate matter and road dust', Science of the Total Environment, Vol. 269, pp. 131-144.
41. 2', Chemical Communications, Vol. 22, pp.2814-2815.
42. Health and Safety Executive (1990) Occupational exposure limits, Guidance note EH 40910, Her Majesty's Stationary Office, London.
43. Heck, R.M., and Farrauto, R.J. (2001) 'Automobile exhaust catalysts', Applied Catalysis A, Vol. 221, pp.443-457.
44. Heitland, P. and Köster, H.D. (2006) 'Biomonitoring of 30 trace elements in urine of children and adults by ICP-MS', Clinica Chimica Acta, Vol. 365, pp.310-318.
45. Helmers, E. (1997) 'Platinum emission rate of automobiles with catalytic converters - comparison and assessment of results from different approaches', Environmental Science and Pollution Research, Vol. 4, pp. 100-103.
46. Helmers, E., Mergel, N., and Barchet, R. (1994) 'Platinum in ash from sewage sludge incinerators and in grass', Umweltwissenschaften und Schadstoff-Forschung Zeitschrift für Umweltchemie und Ökotoxikologie, Vol. 6, pp.130-134.
47. Herr, C.E., Jankofsky, M., Angerer, J., Kuster, W., Stilianakis, N.I., Gieler, U. and Eikmann, T. (2003) 'Influences on human internal exposure to environmental platinum', Journal of Exposure Analysis and Environmental Epidemiology, Vol. 13, pp.24-30.
48. 2] in the major organs of Swiss white mice', in Hejzlar, M. (Eds.): Advances in Antimicrobial and Antineoplastic Chemotherapy, University Park Press, Baltimore, Vol. 2, pp.241-242.
49. Holbrook, D.J. (1977) 'Content of platinum and palladium in rat tissue: Correlation of tissue concentration of platinum and palladium with biochemical effects', Research Triangle Park, North Carolina, US Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, pp.21 (EPA/600/1-77/051).
50. Hughes, E.G. (1980) 'Medical surveillance of platinum refinery workers', Journal of the Society of Occupational Medicine, Vol. 30, pp.27-30.
51. Hunter, D., Milton, R. and Perry, K.M.A. (1945) 'Asthma caused by the complex salts of platinum', British Journal of Industrial Medicine Vol. 2, pp.92-98.
52. Hutchinson, E.J., Farago, M.E and Simpson, P.R. (2000) 'Changes in platinum concentrations in soils and dusts from UK cities', in Zercini, F. and Alt, F. (Eds): Anthropogenic Platinum-Group Element Emissions. Their Impact on Man and Environment, Springer-Verlag, Berlin, pp.57-64.
53. IARC (1981) Some Antineoplastic and Immunosuppressive Agents, Lyon, France, Vol. 26.
54. Iavicoli, I., Bocca, B., Carelli, G., Caroli, S., Caimi, S., Alimonti, A. and Fontana, L. (2007) 'Biomonitoring of tram drivers exposed to airborne platinum, rhodium and palladium', International Archives of Occupational Environmental Health, Vol. 81, pp. 109-114.
55. Iavicoli, I., Bocca, B., Petrucci, F., Senofonte, O., Carelli, G., Alimonti, A. and Caroli, S. (2004) 'Biomonitoring of traffic police officers exposed to airborne platinum', Occupational and Environmental Medicine, Vol. 61, pp.636-639.
56. Iavicoli, I., Carelli, G., Bocca, B., Caimi, S., Fontana, L. and Alimonti, A. (2008) Environmental and biological monitoring of iridium in the city of Rome, Chemosphere, Vol. 71, No. 3. pp.568-573.
57. Johnson, M. (2001) Precions Metal Division, Johnson Matthey Publishing Company, London, UK. Available online at: http://www.matthey.com/divisions/precious
58. Johnson, D.E., Tillery, J.B. and Prevost, R.J. (1975) 'Levels of palladium, platinum and lead in populations of Southern California', Environmental Health Perspective, Vol. 12, pp.27-33.
59. König, H.P., Hertel, R.F., Koch, W. and Rosner, G. (1992) 'Determination of the platinum emissions from three-way catalyst-equipped gasoline engine'. Atmospheric Environment, Vol. 26, pp.741-745.
60. Krächler, M., Alimonti, A., Petrucci, F., Irgolic, K.J., Forastiere, F. and Caroli, S. (1998) 'Analytical problems in the determination of platinum group metals in urine by quadrupole and magnetic sector field inductively coupled plasma mass spectrometry', Analytica Chimica Acta Vol. 363, pp.1-10.
61. Krämer, U., Koch, T., Ranft, U., Ring, J. and Behrendt, H. (2000) 'Traffic- related air pollution is associated with atopy in children living in urban areas'. Epidemiology, Vol. 11, pp.64-70.
62. Kränke, B., Binde, M., Derhaschnig, J., Komericki, P., Pirkhammer, D., Ziegler, V. and Aberer, W. (1995) 'Testing with the "Austrian standard patch test series" - test epidemiologic data and results', Wien Klin Wochenschr, Vol. 107, pp.323-330.
63. Kreyling, W.G., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Schulz, H., Oberdorster, G. and Ziesenis, A. (2002) 'Translocation of ultra fine insoluble iridium particles from lung epithelium to extra pulmonary organs is size dependent but very low', Journal of Toxicological and Environmental Health, Vol. 25, pp.1513-1530.
64. Lanvers-Kaminsky, C., Krefeld, B., Dinnesen, A.G., Deuster, D., Seifert, E., Würthwein, G., Jaehde, U., Pieck, A.C. and Boos, J. (2005) 'Continuous or repeated prolonged cisplatin infusions in children: A prospective study on ototoxicity, platinum concentrations, and standard serum parameters', Pediatric Blood Cancer, Vol. 47, pp. 183-193.
65. Linnett, P.J. and Hughes, E.G. (1999) '20 years of medical surveillance on exposure to allergenic and non-allergenic platinum compounds: The importance of chemical speciation', Occupational and Environmental Medicine, Vol. 56, pp. 191-196.
66. Marcusson, J.A., Cederbrant, K. and Heilborn, J. (1998) 'Indium and iridium allergy in patients exposed to dental alloys', Contact Dermatitis, Vol. 38, pp.297-298.
67. Merget, R. (2000) 'Occupational platinum salt allergy. Diagnosis, prognosis, prevention and therapy', in Zereini, F. and Alt, F. (Eds): Antropogenic Platinum-Group Element Emissions. Their Impact on Man and Environment, Springer-Verlag, Berlin, pp.257-266.
68. Messerschmidt, J., Alt, F., Tölg, G., Angerer, J. and Schaller, K.H. (1992) 'Adsorptive voltammetric procedure for the determination of platinum base-line levels in human body fluids', Fresenius' Journal of Analytical Chemistry, Vol. 343, pp.391-394.
69. Messerschmidt, J., von Bohlen, A., Alt, F. and Klockenkämper, R. (2000) 'Separation and enrichment of palladium and gold in biological and environmental samples, adapted to the determination by total reflection X-ray fluorescence', Analyst, Vol. 125, pp.397-399.
70. Moldovan, M., Palacios, M.A., Gómez, M.M., Morrison, G., Rauch, S., McLeod, C., Ma, R., Caroli, S., Alimonti, A., Petrucci, F., Bocca, B., Schramel, P., Zischka, M., Pettersson, C., Wass, U., Luna, M., Saenz, J.C. and Santamaría, J. (2002) 'Environmental risk of particulate and soluble platinum group elements released from gasoline and diesel engine catalytic converters', Science of the Total Environment, Vol. 296, pp.199-208.
71. Moldovan, M., Rauch, S., Gómez, M., Palacios, M.A. and Morrison, G.M. (2001) 'Bioaccumulation of palladium, platinum and rhodium from urban particulates and sediments by the freshwater isopod Asellus aquaticus', Water Research, Vol. 35, pp.4175-4183.
72. Moore Jr., W., Hysell, D., Crocker, W. and Stara, J. (1975a) 'Biological fate of a single adminstration of 191Pt in rats following different routes of exposure', Environmental Research, Vol. 9, pp.152-158.
73. Moore Jr., W., Hysell, D., Hall, L., Campbell, K. and Stara, J. (1975b) 'Preliminary studies on the toxicity and metabolism of palladium and platinum', Environmental Health Perspective, Vol. 10, pp.63-71.
74. Murdoch, R.D. and Pepys, J. (1987) 'Platinum group metal sensitivity: reactivity to platinum group metal salts in platinum halide salt-sensitive workers', Annals of Allergy, Vol. 59, pp.464-469.
75. National Center for Environmental Health (NCEH) (2003) Second National Report on Human Exposure to Environmental Chemicals, Vol. 02-0716, Department of Health and Human Services, Atlanta, Georgia.
76. Nygren, O., Vaughan, G.T., Florence, T.M., Morrison, G.M.P., Warner, L.M. and Dale, L.S. (1990) 'Determination of platinum in blood by adsorptive voltammetry', Analytical Chemistry, Vol. 62, pp.1637-1640.
77. Palacios, M.A., Gómez, M.M., Moldovan, M., Morrison, G.M., Rauch, S., McLeod, C., Li, R., Laserna, J., Lucena, P., Caroli, S., Alimonti A., Petrucci, F., Bocca, B., Schramel, P., Lustig, S., Wass, U., Stenbom, B., Luna, M., Saenz, J.C., Santamaría, J. and Torrents, J.M. (2000) 'Platinum-group elements: Quantification in collected exhaust fumes and studies of catalyst surfaces', Science of the Total Environment, Vol. 257, pp.1-15.
78. Parent, M., Vanhoe, H., Moens, L. and Dams, R. (1996) 'Determination of low amounts of platinum in environmental and biological materials using thermospray nebulization inductively coupled plasma-mass spectrometry', Fresenius' Journal of Analytical Chemistry, Vol. 354, pp.664-667.
79. Paschal, D.C., Ting, B.G., Morrow, J.C., Pirkle, J.L., Jackson, R.J., Sampson, E.J., Miller, D.T. and Caldwell, K.L. (1998) 'Trace metals in urine of United States residents: Reference range concentrations', Environmental Research A, Vol. 76, pp.53-59.
80. Petrucci, F., Bocca, B., Alimonti, A. and Caroli, S. (2000) 'Determination of Pd, Pt and Rh in airborne particulate and road dust by high-resolution ICP-MS: A preliminary investigation of the emission from automotive catalysts in the urban area of Rome', Journal of Analytical Atomic Spectrometry, Vol. 15, pp.525-528.
81. Petrucci, F., Violante, N., Senofonte, O., Cristaudo, A., Di Gregorio, M., Forte, G. and Alimonti, A. (2005) 'Biomonitoring of a worker population exposed to platinum dust in a catalyst production plant', Occupational and Environmental Medicine, Vol. 62, pp.27-33.
82. Philippeit, G. and Angerer, J. (2001) 'Determination of palladium in human urine by high performance chromatography and ultraviolet detection after ultraviolet photolysis and selective solid-phase extraction', Journal of Chromatography B, Vol. 760, pp.237-245.
83. Rauch, S. and Morrison, G.M. (1999) 'Platinum uptake by the freshwater isopod Asellus aquaticus in urban rivers', Science of the Total Environment, Vol. 235, pp.261-268.
84. Ravindra, K., Bencs, L. and Van Grieken, R. (2004) 'Platinum group elements in the environment and their health risk', Science of the Total Environment, Vol. 318, pp.1-43.
85. Rodushkin, I., Ödman, F. and Branth, S. (1999) 'Multielement analysis of whole blood by high resolution inductively coupled plasma mass spectrometry', Fresenius' Journal of Analytical Chemistry, Vol. 364, pp.338-346.
86. Rosner, G. and Merget, R. (2000) 'Evaluation of the health risk of platinum emissions from automotive emission control catalyts', in Zereini, F. and Alt, F. (Eds): Anthropogenic Platinum-Group Element Emissions. Their Impact on Man and Environment, Springer-Verlag, Berlin, pp.267-281.
87. Rudolph, E., Hann, S., Stingeder, G. and Reiter, C. (2005) 'Ultra-trace analysis of platinum in human tissue samples', Analytical and Bioanalytical Chemistry, Vol. 382, pp.1500-1506.
88. Salma, I., Balashazy, I., Winkler-Heil, R., Hofmann, W. and Zaray, Gy. (2002) 'Effect of particle mass size distribution on the deposition of aerosols in the human respiratory system', Journal of Aerosol Science Vol. 33, pp.119-132.
89. Scheuplein, R., Charnley, G. and Dourson, M. (2002) 'Differential sensitivity of children and adults to chemical toxicity I. Biological basis', Regulatory Toxicology Pharmacology, Vol. 35, pp.429-447.
90. Schierl, R. (2000) 'Urinary biomonitoring of platinum in occupational medicine', in Zereini, F. and Alt, F. (Eds): Anthropogenic Platinum-Group Element Emissions. Their Impact on Man and Environment Springer-Verlag, Berlin, pp.237-242.
91. Schierl, R., Fries, H.G., van de Weyer, C. and Fruhmann, G. (1998) 'Urinary excretion of platinum from platinum industry workers', Occupational and Environmental Medicine, Vol. 55, pp.138-140.
92. Schins, R.P.F., Polat, D., Begerow, J., Turfeld, M., Becker, A. and Borm, P.J.A. (2004) 'Platinum levels in nasal lavage fluid as a biomarker for traffic-related exposure and inflammation in children', Science of the Total Environment, Vol. 334-335, pp.447-445.
93. Schramel, P. and Wendler, I. (1999) 'ICP-MS collective methods', in Angerer, J. and Schaller, K.H. (Eds): Analyses of Hazardous Substances in Biological Materials, Whiley-VCH, Weinheim, Vol. 6, pp.79-109.
94. Schramel, P., Wendler, I. and Lustig, S. (1995) 'Capability of ICP-MS (pneumatic nebulization and ETV) for Pt-analysis in different matrices at ecologically relevant concentrations', Fresenius' Journal of Analytical Chemistry, Vol. 353, pp.115-118.
95. Schuster, M., Schwarzer, M. and Risse, G. (2000) 'Determination of palladium in environmental samples', in Zereini. F. and Alt, F. (Eds): Anthropogenic Platinum-Group Element Emissions. Their Impact on Man and Environment, Springer-Verlag, Berlin, pp.173-182.
96. Selgrade, M.K., Plopper, C.G., Gilmour, M.I., Conolly, R.B. and Foos, B.S. (2008) 'Assessing the health effects and risks associated with children's inhalation exposures - asthma and allergy', Journal of Toxicological and Environmental Health A, Vol. 71, pp.196-207.
97. Shah, M., Lewis, F.M. and Gawkrodger, D.J. (1997) 'Patch testing in children and adolescents: Five years' experience and follow-up', Journal of the American Academy of Dermatology, Vol. 37, pp.964-968.
98. Spezia, S., Bocca, B., Forte, G., Gatti, A., Mincione, G., Ronchi, A. Bavazzano, P., Alimonti, A. and Minoia, C. (2005) 'Comparison of inductively coupled plasma mass spectrometry techniques in the determination of platinum in urine: Quadrupole vs. sector field', Rapid Communication in Mass Spectrometry, Vol. 19, pp.1551-1556.
99. Stevens, A. (1998) Platinum Levels in Raptor Populations throughout Sweden, Master Thesis, Chalmers University of Technology, Gothenburg, Sweden.
100. Stöhr, W., Paulides, M., Bielack, S., Jürgens, H., Koscielniak, E., Rossi, R., Langer, T. and Beck, J.D. (2007) 'Nephrotoxicity of cisplatin and carboplatin in sarcoma patients: A report from the late effects surveillance system', Pediatric Blood Cancer, Vol. 48, pp.140-147.
101. Strachan, D., Sibbald, B., Weiland, S., Aït-Khaled, N., Anabwani, G., Anderson, H.R., Asher, M.I., Beasley, R., Björkstén, B., Burr, M., Clayton, T., Crane, J., Ellwood, P., Keil, U., Lai, C., Mallol, J., Martinez, F., Mitchell, E., Montefort, S., Pearce, N., Robertson, C., Shah, J., Stewart, A., von Mutius, E. and Williams, H. (1997) 'Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC)', Pediatric Allergy and Immunology, Vol. 8. pp.161-176.
102. Sures, B., Zimmermann, S., Messerschmidt, J. and von Bohlen, A. (2002) 'Relevance and analysis of traffic related platinum group metals (Pt, Pd, Rh) in the aquatic biosphere, with emphasis on palladium', Ecotoxicology, Vol. 11, pp.385-392.
103. Vaughan, G.T. and Florence, M.T. (1992) 'Platinum in the human diet, blood, hair and excreta', Science of the Total Environment, Vol. 11, pp.47-58.
104. Violante, N., Petrucci, F., Senofonte, O., Cristaudo, A., Di Gregorio, M., Forte, G. and Alimonti, A. (2005) 'Assessment of workers' exposure to palladium in a catalyst production plant', Journal of Environmental Monitoring, Vol. 7. pp.463-469.
105. Wataha, J.C. and Hanks, C.T. (1996) 'Biological effects of palladium and risk of using palladium in dental casting alloys', Journal of Oral Rehabilitation, Vol. 23, pp.309-320.
106. Wei, C. and Morrison, G.M. (1994) 'Platinum analysis and speciation in urban gullypots', Analytica Chimica Acta, Vol. 284, pp.587-592.
107. WHO (1986) Environmental Health Criteria 59-Principles for Evaluating Risks from Chemicals During Infancy and Early Childhood: The Need for a Special Approach, International Programme on Chemical Safety, Geneva.
108. WHO (1991) Environmental Health Criteria 125-Platinum, International Programme on Chemical Safety, Geneva.
109. WHO (2002) Environmental Health Criteria 226-Palladium, International Programme on Chemical Safety, Geneva.
110. Wild, C.P. and Kleinjans, J. (2003) 'Children and increased susceptibility to environmental carcinogens: Evidence or empathy?', Cancer Epidemiology Biomarkers and Prevention, Vol. 12, pp.1389-1394.
111. Wilhelm, M., Ewers, U. and Schulz, C. (2004) 'Revised and new reference values for some trace elements in blood and urine for human biomonitoring in environmental medicine', International Journal of Hygiene and Environmental Health, Vol. 207, pp.69-73.
112. Wjst, M., Reitmeir, P., Dold, S., Wulff, A., Nicolai, T., von Loeffelholz-Colberg, E.F. and von Mutius, E. (1993) 'Road traffic and adverse effects on respiratory health in children', British Medical Journal, Vol. 307, pp.596-600.
113. Zereini, F. and Alt, F. (Eds) (2000) Anthropogenic Platinum-Group Element Emissions. Their Impact on Man and Environment, Springer-Verlag, Berlin, p.308.
114. Zereini, F., Skerstupp, B., Alt, F., Helmers, E. and Urban, H. (1997) 'Geochemical behaviour of platinum-group elements (PGE) in particulate emissions by automobile exhaust catalysts: Experimental results and environmental investigations', Science of the Total Environment, Vol. 206, pp.137-146.
115. Zereini, F., Wiseman, C., Alt, F., Messerschmidt, J., Müller, J. and Urban, H. (2001) 'Platinum and rhodium concentrations in airborne particulate matter in Germany from 1988 to 1998', Environmental Science and Technology, Vol. 35, pp.1996-2000.
116. Zhang, B.L., Sun, W.Y. and Tang, W.X. (1997) 'Determination of the association constant of platinum(II) to metallothionein', Journal of Inorganic Biochemistry, Vol. 65, pp.295-298.
117. Zhang, Q., Zhong, W., Xing, B., Tang, W. and Chen, Y. (1998) 'Binding properties and stoichometries of a palladium(II) complex to metallothioneins in vivo and in vitro', Journal of Inorganic Biochemistry, Vol. 72, pp.195-200.
118. Zhong, W., Zhang, Q., Yan, Y., Yue, S., Zhang, B. and Tang, W. (1997) 'Reaction of a platinum(II) complex with native Cd, Zn-metallothionein in vitro', Journal of Inorganic Biochemistry, Vol. 66, pp.179-185.