Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water

Journal of Biological Chemistry

Volumn 283, Issue 40, 2008, Pages 27270-27278

  Ouellet, Yannick H ^a   Daigle, Richard ^a   Lagüe, Patrick ^a   Dantsker, David ^b   Milani, Mario ^c   Bolognesi, Martino ^c   Friedman, Joel M ^b   Guertin, Michel ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; COORDINATION REACTIONS; DETOXIFICATION; DYNAMICS; HYDROGEN; INTERNAL OXIDATION; LIGANDS; MOLECULAR DYNAMICS; MOLECULES; NITRIC OXIDE; PORPHYRINS; QUANTUM CHEMISTRY; RATE CONSTANTS; REACTION KINETICS;

ENHANCED REACTIVITIES; HEME IRONS; HEME POCKETS; HEME PROTEINS; HORSE HEART MYOGLOBINS; IRON ATOMS; KINETIC BARRIERS; KINETIC MEASUREMENTS; LIGAND BINDINGS; MOLECULAR DYNAMICS SIMULATIONS; MYCOBACTERIUM TUBERCULOSIS; RAPID OXIDATIONS; TRUNCATED HEMOGLOBINS; UPPER LIMITS; WATER MOLECULES;

HEMOGLOBIN;

GLYCINE; HEMOGLOBIN; TYROSINE; WATER; BACTERIAL PROTEIN; GLBN PROTEIN, BACTERIA; HEME; IRON; LIGAND; MYOGLOBIN; NITRATE; NITRIC OXIDE; TRUNCATED HEMOGLOBIN;

ARTICLE; ENZYME KINETICS; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR STABILITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BINDING SITE; CHEMISTRY; GENETICS; HORSE; KINETICS; METABOLISM; MUTATION; OXIDATION REDUCTION REACTION; STRUCTURE ACTIVITY RELATION;

EQUIDAE; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; BACTERIAL PROTEINS; BINDING SITES; HEME; HORSES; HYDROGEN BONDING; IRON; KINETICS; LIGANDS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; MYOGLOBIN; NITRATES; NITRIC OXIDE; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRUNCATED HEMOGLOBINS; WATER;

EID: 55249106911     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804215200     Document Type: Article

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