Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration

European Journal of Immunology

Volumn 38, Issue 9, 2008, Pages 2548-2556

  Duffy, S Mark ^a   Cruse, Glenn ^a   Cockerill, Sarah L ^a   Brightling, Chris E ^a   Bradding, Peter ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b GLENFIELD HOSPITAL   (United Kingdom)

Author keywords

Chemotaxis; Ion channel; KCa3.1; Mast cell; Prostaglandin E2

Indexed keywords

6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; BUTAPROST; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHEMOATTRACTANT; CHEMOKINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCA3.1; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; UNCLASSIFIED DRUG; 1 ETHYL 2 BENZIMIDAZOLINONE; 1-ETHYL-2-BENZIMIDAZOLINONE; 6-ISOPROPOXY-9-OXOXANTHENE-2-CARBOXYLIC ACID; BENZIMIDAZOLE DERIVATIVE; CALCIUM CHANNEL STIMULATING AGENT; DRUG DERIVATIVE; PROSTAGLANDIN E1; PROSTAGLANDIN EP2 RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; XANTHONE DERIVATIVE;

AIRWAY; ARTICLE; CELL MIGRATION; CHANNEL GATING; CHEMOTAXIS; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG POTENCY; HUMAN; HUMAN CELL; IMMUNOMODULATION; LUNG ALVEOLUS CELL; MAST CELL; MIGRATION INHIBITION; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RECEPTOR BINDING; RECEPTOR BLOCKING; SMOOTH MUSCLE; CELL MOTION; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; HISTAMINE RELEASE; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

ALPROSTADIL; BENZIMIDAZOLES; CALCIUM CHANNEL AGONISTS; CELL MOVEMENT; CHEMOTAXIS; DINOPROSTONE; HISTAMINE RELEASE; HUMANS; MAST CELLS; POTASSIUM CHANNELS; PROSTAGLANDIN ANTAGONISTS; RECEPTORS, PROSTAGLANDIN E; XANTHONES;

EID: 55249097262     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200738106     Document Type: Article

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