The effect of continuous release of recombinant human epidermal growth factor (rh-EGF) in chitosan film on full thickness excisional porcine wounds

Annals of Plastic Surgery

Volumn 61, Issue 4, 2008, Pages 457-462

  Hong, Joon Pio ^a   Kim, Yeun Wha ^b   Lee, Sang Kil ^c   Kim, Sun Hee ^d   Min, Kyung Hyun ^d  

^a University of Ulsan College of Medicine   (South Korea)

^b Asan Institute of Life Sciences   (South Korea)

^c Inje University   (South Korea)

^d Materials Science Laboratory   (South Korea)

Author keywords

Chitosan film; Full thickness wounds; Recombinant human epidermal growth factor

Indexed keywords

CHITOSAN; EOSIN; HEMATOXYLIN; MONOCLONAL ANTIBODY KI 67; RECOMBINANT EPIDERMAL GROWTH FACTOR; DRUG CARRIER; EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONTROLLED STUDY; DOMESTIC PIG; DRUG EFFECT; DRUG RELEASE; DRUG RESPONSE; EPITHELIZATION; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; WOUND; WOUND HEALING; ANIMAL; DELAYED RELEASE FORMULATION; HUMAN; HYDROCOLLOID DRESSING; INJURY; PATHOLOGY; PENETRATING TRAUMA; SKIN; SWINE;

ANIMALS; BANDAGES, HYDROCOLLOID; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; EPIDERMAL GROWTH FACTOR; HUMANS; RECOMBINANT PROTEINS; SKIN; SWINE; WOUND HEALING; WOUNDS, PENETRATING;

EID: 55249096066     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/SAP.0b013e31815bfeac     Document Type: Article

References (26)

1. Singer AJ, Clark RAF. Mechanisms of disease: cutaneous wound healing. N Engl J Med. 1999;341:738-746.
2. Schaffer CJ, Narrey LB. Cell biology of wound healing. Int Rev Cytol. 1996;169:151-181.
3. Greenhalgh DG. The role of growth factors in wound healing. J Trauma. 1996;41:159-167.
4. Bennett SP, Griffiths GD, Schor AM, et al. Growth factors in the treatment of diabetic foot ulcers. Br J Surg. 2003;90:133-146.
5. Wieman TJ. Clinical efficacy of becarplermin (rhPDGF-BB) gel. Am J Surg. 1998;176:74s-79s.
6. Smiell JM, Wieman TJ, Steed DL, et al. Efficacy and safety of bercaplermin (recombinant human platelet derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies. Wound Rep Reg. 1999;7:335-346.
7. Embil JM, Kapp K, Sibblad G, et al. Recombinant human platelet derived growth factor-BB (becarplermin) for healing lower extremity diabetic ulcers: an open label clinical evaluation of efficacy. Wound Repair Regen. 2000;8:162-168.
8. Tsang MW, Kam G, Keubg WKR, et al. Human epithelial growth factor enhances healing of diabetic foot ulcers. Diabetes Care. 2003;26:1856-1861.
9. Brown GL, Curtsinger L, Jurkiewics MJ, et al. Stimulation of healing of chronic wounds by epidermal growth factor. Plast Reconstr Surg. 1991;88:189-196.
10. Cohen S. Isolation of mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new born animal. J Biol Chem. 1962;237:1555-1562.
11. Nanney LB. Epidermal and dermal effect of epidermal growth factor during wound repair. J Invest Dermatol. 1990;94:624-629.
12. Servold SA. Growth factor impact on wound healing. Clin Podiatr Med Surg. 1991;8:937-953.
13. Brown GL, Curtsinger L, Brightwell GR, et al. Enhancement of epidermal regeneration by biosynthetic epidermal growth factor. J Exp Med. 1986;163:1319-1324.
14. Brown GL, Curtsinger LJ, White M, et al. Acceleration of tensile strength of incisions treated with EGF and TGF-β. Ann Surg. 1988;208:788-794.
15. Hong JP, Kim YW, Jung HD, et al. The effect of various concentrations of human recombinant epidermal growth factor (hr-EGF) on split-thickness skin wounds. Int Wound J. 2006;3:123-130.
16. Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm Res. 1998;15:1326-1331.
17. Howling GI, Dettmar PW, Goddard PA, et al. The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro. Biomaterials. 2001;22:2959-2966.
18. Ishihara M, Ono K, Sato M, et al. Acceleration of wound contraction and healing with a photocrosslinkable chitosan hydrogel. Wound Repair Regen. 2001;9:513-521.
19. Alemdaroglu C, Degim Z, Celebi N, et al. An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor. Burns. 2006;32:319-327.
20. Danilenko DM, Ring BD, Tarpley JE, et al. Differing targets and effects of keratinocyte growth factor, platelet-derived growth factor-BB, epidermal growth factor, and neu differentiation factor. Am J Pathol. 1995;147:1261-1277.
21. Grone A, Engelhardt P, Zurbriggen A. Canine distemper virus infection: proliferation of canine footpad keratinocytes. Vet Pathol. 2003;40:574-578.
22. Buckley A, Davidson JM, Kamerath CD, et al. Sustained release of epidermal growth factor accelerates wound repair. Proc Natl Acad Sci. 1985;82:7340-7344.
23. Tanaka A, Nagate T, Matsuda H. Acceleration of wound healing by gelatin film dressing with epidermal growth factor. J Vet Med Sci. 2005;67:909-913.
24. Hong JP, Jung HD, Kim YW. Recombinant human Epidermal growth factor (EGF) to enhance healing for diabetic foot ulcers. Ann Plast Surg. 2006;56:394-398.
25. Bartone FF, Adickes E. Chitosan: effects on wound healing in urogenital tissue: preliminary report. J Urol. 1988;140:1134-1137.
26. Knauer DJ, Wiley HS, Cunningham DD. Relationship between epidermal growth factor receptor occupancy and mitogenic response. Quantitative analysis using a steady state model system. J Biol Chem. 1984; 259:5623-5631.