Effects of137Cs γ irradiation on cognitive performance and measures of anxiety in Apoe-/- and wild-type female mice

Radiation Research

Volumn 170, Issue 4, 2008, Pages 422-428

  Acevedo, Summer F ^a   McGinnis, Gwendolyn ^a   Raber, Jacob ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOENZYME; CESIUM 137; APOLIPOPROTEIN E; CESIUM;

ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; BRAIN FUNCTION; COGNITION; CONTROLLED STUDY; FEMALE; GAMMA IRRADIATION; GENOTYPE; MEMORY CONSOLIDATION; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKULL IRRADIATION; SPATIAL MEMORY; TASK PERFORMANCE; ANIMAL; C57BL MOUSE; GAMMA RADIATION; GENETICS; MAZE TEST; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIATION EXPOSURE; RADIATION INJURY;

MUS;

ANIMALS; ANXIETY; APOLIPOPROTEINS E; CESIUM RADIOISOTOPES; COGNITION; FEMALE; GAMMA RAYS; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RADIATION INJURIES, EXPERIMENTAL;

EID: 55249096034     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1494.1     Document Type: Article

References (44)

1. J. Poirier, Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci. 17, 525-530 (1994).
2. H. Sheng, D. T. Laskowitz, E. Bennett, D. E. Schmechel, R. D. Bart, A. M. Saunders, R. D. Pearlstein, A. D. Roses and D. S. Warner, Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. J. Cereb. Blood Flow Metab. 18, 361-366 (1998).
3. A. D. Roses and A. M. Saunders, ApoE, Alzheimer's disease, and recovery from brain stress. Ann. NY Acad. Sci. 26, 200-212 (1997).
4. A. M. Saunders, W. J. Strittmatter, D. Schmechel, P. H. George-Hyslop, M. A. Pericak-Vance, S. H. Joo, B. Rosi, J. F. Gusella, D. R. Crapper-MacLachan and M. J. Alberts, Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43, 1467-1472 (1993).
5. E. H. Corder, A. M. Saunders, W. J. Strittmatter, D. E. Smechel, P. C. Gaskell, Jr., A. D. Roses, M. A. Pericak-Vance, G. W. Small and J. L. Haines, The apolipoprotein E e4 allele and sex-specific risk of Alzheimer's disease. J. Am. Med. Assoc. 273, 373-374 (1995).
6. L. A. Farrer, L. A. Cupples, J. L. Haines, B. Hyman, W. A. Kukull, R. Mayeux, R. H. Myers, M. A. Pericak-Vance, N. Risch and C. M. van Duijn, Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. J. Am. Med. Assoc. 278, 1349-1356 (1997).
7. R. Mayeux, R. Ottman, G. Maestre, C. Ngai, M. X. Tang, H. Ginsberg, M. Chung, B. Tycko and M. Shelanski, Synergistic effects of traumatic head injury and apolipoprotein-e4 in patients with Alzheimer's disease. Neurology 45, 555-557 (1995).
8. A. D. Roses, J. Gilbert and P. T. Xu, APOE and Alzheimer disease: Human susceptibility genes and appropriate transgenic models. Brain Pathol. 7, 1033-1036 (1997).
9. -/- mice: Isoform-specific effects on neurodegeneration. J. Neurosci. 19, 4867-4880 (1999).
10. J. Raber, D. Wong, G-Q. Yu, M. Buttini, R. W. Mahley, R. E. Pitas and L. Mucke, Alzheimer's disease: Apolipoprotein E and cognitive performance. Nature 404, 352-354 (2000).
11. E. Masliah, M. Mallory, M. Alford, I. Veinbergs and A. D. Roses, Apolipoprotein E role in maintaining the integrity of the aging central nervous system. In Apolipoprotein E and Alzheimer's Disease (A. D. Roses, K. S. Weisgraber and Y. Christen, Eds.). Springer-Verlag, Berlin, 1996.
12. L. Lomnitski, R. Kohen, Y. Chen, E. Shohami, V. Trembovler, T. Vogel and D. M. Michaelson, Reduced levels of antioxidants in brains of apolipoprotein E-deficient mice following closed head injury. Pharmacol. Biochem. Behav. 56, 669-673 (1997).
13. L. Lomnitski, S. Chapman, A. Hochman, R. Kohen, E. Shohami, Y. Chen, V. Trembovler and D. M. Michaelson, Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury. Biochim. Biophys. Acta 1453, 359-368 (1999).
14. G. E. Sheline, W. M. Wara and V. Smith, Therapeutic irradiation and brain injury. Int. J. Radiat. Oncol. Biol. Phys. 6, 1215-1228 (1980).
15. O. K. Abayomi, Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol. 35, 659-663 (1996).
16. R. W. Butler, J. M. Hill, P. G. Steinherz, P. A. Meyers and J. L. Finlay, Neuropsychologic effects of cranial irradiation, intrathecal methotrexate, and systemic methotrexate in childhood cancer. J. Clin. Oncol. 12, 2621-2629 (1994).
17. M. Dennis, B. J. Spiegler, M. C. Obonsawin, B. L. Maria, C. Cowell, H. J. Hoffman, E. B. Hendrick, R. P. Humphreys, J. D. Bailey and R. M. Ehrlich, Brain tumors in children and adolescents - III. Effects of radiation and hormone status on intelligence and on working, associative and serial-order memory. Neuropsychologia 30, 257-275 (1992).
18. L. Ellenberg, J. G. McComb, S. E. Siegel and S. Stowe, Factors affecting intellectual outcome in pediatric brain tumor patients. Neurosurgery 21, 638-644 (1987).
19. J. H. Kramer, M. R. Crittenden, F. E. Halberg, W. M. Wara and M. J. Cowan, A prospective study of cognitive functioning following low-dose cranial radiation for bone marrow transplantation. Pediatrics 90, 447-450 (1992).
20. D. P. Waber, N. J. Tarbell, C. M. Kahn, R. D. Gelber and S. E. Sallan, The relationship of sex and treatment modality to neuropsychologic outcome in childhood acute lymphoblastic leukemia. J. Clin. Oncol. 10, 810-817 (1992).
21. E. Seaver, R. Geyer, S. Sulzbacher, M. Warner, L. Batzel, J. Milstein and M. Berger, Psychosocial adjustment in long-term survivors of childhood medulloblastoma and ependymoma treated with craniospinal irradiation. Pediat. Neurosurg. 20, 248-253 (1994).
22. I. Syndikus, D. Tait, S. Ashley and L. Jannoun, Long-term follow-up of young children with brain tumors after irradiation. Int. J. Radiat. Oncol. Biol. Phys. 30, 781-787 (1994).
23. D. D. Roman and P. W. Sperduto, Neuropsychological effects of cranial radiation: current knowledge and future directions. Int. J. Radiat. Oncol. Biol. Phys. 31, 983-998 (1995).
24. J. Radcliffe, G. R. Bunin, L. N. Sutton, J. W. Goldwein and P. C. Phillips, Cognitive deficits in long-term survivors of childhood medulloblastoma and other noncortical tumors: age-dependent effects of whole brain irradiation. Int. J. Dev. Neurosci. 12, 327-334 (1994).
25. T. A. Glauser and R. J. Packer, Cognitive deficits in long-term survivors of childhood brain tumors. Child's Nerv. Syst. 7, 2-12 (1991).
26. S. Mizumatsu, M. Monje, D. Morhardt, R. Rola, T. D. Palmer and J. R. Fike, Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 63, 4021-4027 (2003).
27. M. L. Monje, S. Mizumatsu, J. R. Fike and T. D. Palmer, Irradiation induces neural precursor-cell dysfunction. Nat. Med. 8, 955-962 (2002).
28. J. Raber, R. Rola, A. LeFevour, D. Morhardt, J. Curley, S. Mizumatsu, S. R. VandenBerg and J. R. Fike, Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat. Res. 162, 39-47 (2004).
29. L. Villasana, S. Acevedo, C. Poage and J. Raber, Sex- and ApoE isoform-dependent effects of radiation on cognitive function. Radiat. Res. 166, 883-891 (2006).
30. Y. Higuchi, G. A. Nelson, M. Vazquez, D. T. Laskowitz, J. M. Slater and R. D. Pearlstein, Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation. J. Radiat. Res. 43 (Suppl.), S219-S224 (2002).
31. T. Benice, A. Rizk, T. Pfankuch, S. Kohama and J. Raber, Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity. Neuroscience 137, 413-423 (2006).
32. S. Acevedo, I. de Esch and J. Raber, Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure. Neuropsychopharmacology 32, 665-672 (2007).
33. -/-) mice. Brain Res. 1071, 113-123 (2006).
34. C. L. Limoli, E. Giedzinski, R. Rola, S. Otsuka, T. D. Palmer and J. R. Fike, Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress. Radiat. Res. 161, 17-27 (2004).
35. W. A. Pedersen, S. L. Chan and M. P. Mattson, A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. J. Neurochem. 74, 1426-1433 (2000).
36. C. Brown, E. Wright, C. Colton, P. M. Sullivan, D. T. Laskowitz and M. Vitek, Apolipoprotein E isoform mediated regulation of nitric oxide release. Free Radic. Biol. Med. 32, 1071-1075 (2002).
37. Z. S. Ji, R. D. Miranda, Y. M. Newhouse, K. H. Weisgraber, Y. Huang and R. W. Mahley, Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. J. Biol. Chem. 277, 21821-21828 (2002).
38. 56Fe particles. Adv. Space Res. 39, 981-986 (2006).
39. -/- mice: Possible role in behavioral and metabolic alterations. J. Neurosci. 20, 2064-2071 (2000).
40. -/- mice. Neurobiol. Aging 26, 637-643 (2005).
41. R. Rola, J. Raber, A. Rizk, S. Otsuka, S. R. VandenBerg, D. R. Morhardt and J. R. Fike, Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp. Neurol. 188, 316-330 (2004).
42. A. Ennaceur, N. Neave and J. Aggleton, Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix. Exp. Brain Res. 113, 509-519 (1997).
43. E. Save, B. Poucet, N. Foreman and M. Buhot, Object exploration and reactions to spatial and nonspatial changes in hooded rats following damage to parietal cortex or hippocampal formation. Behav. Neurosci. 106, 447-456 (1992).
44. R. Morris, P. Garrud, J. Rawlins and J. O'Keefe, Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683 (1982).