The inhibitory potencies of monoclonal antibodies to the macrophage adhesion molecule Sialoadhesin are greatly increased following PEGylation

Bioconjugate Chemistry

Volumn 19, Issue 10, 2008, Pages 2088-2094

  Ducreux, Julie ^a   Vanbever, Rita ^a   Crocker, Paul R ^b  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; CELL MEMBRANES; CHROMATOGRAPHY; MACROPHAGES; MOLECULES; SURFACE PLASMON RESONANCE;

ADHESION MOLECULES; ANION EXCHANGE CHROMATOGRAPHY; ANTIGEN-BINDING ACTIVITIES; HALF LIVES; MACROPHAGE ADHESION; PEGYLATED; PEGYLATION; SIALIC ACIDS; SYSTEMIC CIRCULATION; TARGET RECEPTOR;

MONOCLONAL ANTIBODIES;

CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; MACROGOL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3D6; MONOCLONAL ANTIBODY SER 4; SIALIC ACID; SIALOADHESIN; UNCLASSIFIED DRUG;

ANION EXCHANGE CHROMATOGRAPHY; ANTIGEN BINDING; ARTICLE; CONJUGATION; DERIVATIZATION; DRUG POTENCY; DRUG RECEPTOR BINDING; HALF LIFE TIME; HUMAN; HUMAN CELL; MACROPHAGE; MOLECULAR SIZE; PURIFICATION;

EID: 55249090878     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc800259z     Document Type: Article

References (21)

1. Veronese, F. M., and Pasut, G. (2005) PEGylation, successful approach to drug delivery. Drug Discovery Today 10, 1451-1458.
2. Fee, C. J., and Van Alstine, J. M. (2006) PEG-proteins: Reaction engineering and separation issues. Chem. Eng. Sci. 61, 924-939.
3. Davis, L. S., Kavanaugh, A. F., Nichols, L. A., and Lipsky, P. E. (1995) Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis. J. Immunol. 154, 3525-3537.
4. Soriano, A., Salas, A., Salas, A., Sans, M., Gironella, M., Elena, M., Anderson, D. C., Pique, J. M., and Panes, J. (2000) VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice. Lab. Invest. 80, 1541-1551.
5. Crocker, P. R., Mucklow, S., Bouckson, V., McWilliam, A., Willis, A. C., Gordon, S., Milon, G., Kelm, S., and Bradfield, P. (1994) Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains. EMBO J. 13, 4490-4503.
6. van den Berg, T. K., Breve, J. J., Damoiseaux, J. G., Dopp, E. A., Keim, S., Crocker, P. R., Dijkstra, C. D., and Kraal, G. (1992) Sialoadhesin on macrophages: its identification as a lymphocyte adhesion molecule. J. Exp. Med. 176, 647-655.
7. May, A. P., Robinson, R. C., Vinson, M., Crocker, P. R., and Jones, E. Y. (1998) Crystal structure of the N-terminal domain of sialoadhesin in complex with 3′ sialyllactose at 1.85 Å resolution. Mol. Cell 1, 719-728.
8. Crocker, P. R., and Gordon, S. (1996) Properties and distribution of a lectin-like hemagglutinin differentially expressed by murine stromal tissue macrophages. J. Exp. Med. 164, 1862-1875.
9. Schadee-Eestermans, I. L., Hoefsmit, E. C., van de Ende, M., Crocker, P. R., van den Berg, T. K., and Dijkstra, C. D. (2000) Ultrastructural localisation of sialoadhesin (siglec-1) on macrophages in rodent lymphoid tissues. Immunobiology 202, 309-325.
10. Hartnell, A., Steel, J., Turley, H., Jones, M., Jackson, D. G., and Crocker, P. R. (2001) Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Blood 97, 288-296.
11. van den Berg, T. K., van Die, I. V., de Lavalette, C. R., Dopp, E. A., Smit, L. D., van der Meide, P. H., Tilders, F. J., Crocker, P. R., and Dijkstra, C. D. (1996) Regulation of sialoadhesin expression on rat macrophages. Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide. J. Immunol. 157, 3130-3138.
12. Nath, D., Hartnell, A., Happerfield, L., Miles, D. W., Burchell, J., Taylor-Papadimitriou, J., and Crocker, P. R. (1999) Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin. Immunology 98, 213-219.
13. Jiang, H. R., Hwenda, L., Makinen, K., Oetke, C., Crocker, P. R., and Forrester, J. V. (2006) Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis. J. Immunol. 177, 2258-2264.
14. Kobsar, I., Oetke, C., Kroner, A., Wessig, C., Crocker, P., and Martini, R. (2006) Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in PO. Mol. Cell. Neurosci. 31, 685-691.
15. Crocker, P. R., Hartnell, A., Munday, J., and Nath, D. (1997) The potential role of sialoadhesin as a macrophage recognition molecule in health and disease. Glycoconj. J. 14, 601-609.
16. Crocker, P. R., Werb, Z., Gordon, S., and Bainton, D. F. (1990) Ultrastructural localization of a macrophage-restricted sialic acid binding hemagglutinin, SER, in macrophage-hematopoietic cell clusters. Blood 76, 1131-1138.
17. Crocker, P. R., Kelm, S., Dubois, C., Martin, B., McWilliam, A. S., Shotton, D. M., Paulson, J. C., and Gordon, S. (1991) Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages. EMBO J. 10, 1661-1669.
18. Crocker, P. R., and Gordon, S. (1989) Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody. J. Exp. Med. 169, 1333-1346.
19. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
20. Roberts, M. J., Bentley, M. D., and Harris, J. M. (2002) Chemistry for peptide and protein PEGylation. Adv. Drug Delivery Rev. 54, 459-476.
21. Chapman, A. P. (2002) PEGylated antibodies and antibody fragments for improved therapy: a review. Adv. Drug Delivery Rev. 54, 531-545.