TIS21/BTG2 negatively regulates estradiol-stimulated expansion of hematopoietic stem cells by derepressing Akt phosphorylation and inhibiting mTOR signal transduction

Stem Cells

Volumn 26, Issue 9, 2008, Pages 2339-2348

  Bong, Cho Kim ^a   Min, Sook Ryu ^a   Oh, S Paul ^b   In, Kyoung Lim ^a  

^a Ajou University School of Medicine   (South Korea)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Estrogen; Extracellular signal regulated kinase 1 2; Hematopoietic stem cells; Mammalian target of rapamycin; Protein kinase B; TIS21 BTG2 PC3

Indexed keywords

DNA; ESTRADIOL; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE B; STEM CELL ANTIGEN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL COMPARTMENTALIZATION; CELL EXPANSION; CELL ISOLATION; CELL LINEAGE; CELL POPULATION; CELL PROLIFERATION; CELL SELECTION; DNA SYNTHESIS; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME REPRESSION; FEMALE; FIBROBLAST; GENE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LEUKEMIA; MALE; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; TIS21 GENE; WILD TYPE;

ANIMALS; CARRIER PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; ESTRADIOL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FIBROBLASTS; GENES, TUMOR SUPPRESSOR; HEMATOPOIETIC STEM CELLS; IMMEDIATE-EARLY PROTEINS; MALE; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

MAMMALIA; MUS;

EID: 55049105100     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2008-0327     Document Type: Article

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