The tale of FOP, NOGGIN and myristoylation: No data, no proof!

Genetic Counseling

Volumn 19, Issue 3, 2008, Pages 353-355

  Seemann, Petra ^a   Mundlos, S ^b  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; GLYCINE; LIPID; METHIONINE; NOGGIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; GENE MUTATION; HUMAN; LETTER; MYRISTYLATION; NOMENCLATURE; NUCLEOTIDE SEQUENCE; OSSIFYING MYOSITIS; POINT MUTATION; PROTEIN DEGRADATION; PROTEIN MODIFICATION; STANDARD;

ACTIVIN RECEPTORS, TYPE I; CARRIER PROTEINS; DNA MUTATIONAL ANALYSIS; HUMANS; MYOSITIS OSSIFICANS; TERMINOLOGY AS TOPIC;

EID: 55049085000     PISSN: 10158146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (11)

1. FONTAINE K, SEMONIN O., LEGARDE J.P., LENOIR G., LUCOTTE G.: A new mutation of the noggin gene in a French Fibrodysplasia ossificans progressiva (FOP) family. Genet. Couns., 2005, 16, 149-154.
2. GONG Y., KRAKOW D., MARCELINO J., WILKIN D., CHITAYAT D., BABUL-HIRJI R., HUDGINS L., CREMERS C. W., CREMERS F. P., BRUNNER H. G., REINKER K., RIMOIN D. L., COHN D. H., GOODMAN F.R., REARDON W., PATTON M., FRANCOMANO C.A., WARMAN M.L.: Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat. Genet., 1999, 21, 302-304.
3. GROPPE J., GREENWALD J., WIATER E., RODRIGUEZ-LEON J., ECONOMIDES A.N., KWIATKOWSKI W., BABAN K., AFFOLTER M., VALE W.W., BELMONTE J. C., CHOE S.: Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. J. Bone Joint Surg. Am., 2003, 85-A Suppl 3, 52-58.
4. LEHMANN K., SEEMANN P., SILAN F., GOECKE T.O., IRGANG S., KJAER K.W., KJAERGAARD S., MAHONEY M.J., MORLOT S., REISSNER C., KERR B., WILKIE A.O., MUNDLOS S.: A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. Am. J. Hum. Genet., 2007, 81, 388-396.
5. LUCOTTE G., LAGARDE J.P.: Mutations of the noggin and of the activin A type I receptor genes in fibrodysplasia ossificans progressiva (FOP). Genet. Couns., 2007, 18, 349-352.
6. LUCOTTE G., SEMONIN O., FONTAINE K.: Myristoylation defect in the protein noggin can cause fibrodysplasia ossificans progressiva. Calc. Tissues Intern., 2003, 72, 258.
7. LUCOTTE G., SEMONIN O., LUTZ P.: A de novo heterozygous deletion of 42 base-pairs in the noggin gene of a fibrodysplasia ossificans progressiva patient. Clin. Genet., 1999, 56, 469-470.
8. MAURER-STROH S., GOUDA M., NOVATCHKOVA M., SCHLEIFFER A., SCHNEIDER G., SIROTA F. L., WILDPANER M., HAYASHI N., EISENHABER F.: MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins. Genome Biol., 2004, 5, R21.
9. SEMONIN O., FONTAINE K., DAVIAUD C., AYUSO C., LUCOTTE G.: Identification of three novel mutations of the noggin gene in patients with fibrodysplasia ossificans progressiva. Am. J. Med. Genet., 2001, 102, 314-317.
10. WARMAN M.L.: Significant difference of opinion regarding the role of noggin in fibrodysplasia ossificans progressiva. Am. J. Med. Genet., 2002, 109, 162; author reply 163-164.
11. XU M.Q., SHORE E.M., KAPLAN F.S.: Reported noggin mutations are PCR errors. Am. J. Med. Genet., 2002, 109, 161; author reply 163-164.