Diffusion tensor magnetic resonance imaging in spinal cord injury

Concepts in Magnetic Resonance Part A: Bridging Education and Research

Volumn 32, Issue 3, 2008, Pages 219-237

  Ellingson, Benjamin M ^a   Schmit, Brian D ^a   Ulmer, John L ^b   Kurpad, Shekar N ^b  

^a Medical College of Wisconsin and Marquette University   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Diffusion tensor imaging; Diffusion tensor tractography; Spinal cord injury

Indexed keywords

EID: 54949129370     PISSN: 15466086     EISSN: 15525023     Source Type: Journal    
DOI: 10.1002/cmr.a.20112     Document Type: Review

References (146)

1. Sagiuchi T, Iida H, Tachibana S, Kusumi M, Kan S, Fujii K. 2003. Diffusion-weighted MRI in anterior spinal artery stroke of the cervical spinal cord. J Comput Assist Tomogr 27:410-414.
2. Stepper F, Lovblad KO. 2001. Anterior spinal artery stroke demonstrated by echo-planar DWI. Eur Radiol 11:2607-2610.
3. Weidauer S, Dettmann E, Krakow K, Lanfermann H. 2002. Diffusion-weighted MRI of spinal cord infarction. Description of two cases and review of the literature. Nervenarzt 73:999-1003.
4. Mamata H, Jolesz FA, Maier SE. 2005. Apparent diffusion coefficient and fractional anisotropy in spinal cord: age and cervical spondylosis-related changes. J Magn Reson Imaging 22:38-43.
5. Demir A, Ries M, Moonen CT, Vital J, Dehais J, Arne P, et al. 2003. Diffusion-weighted MR imaging with apparent diffusion coefficient and apparent diffusion tensor maps in cervical spondylotic myelopathy. Radiology 229:37-43.
6. Facon D, Ozanne A, Fillard P, Lepeintre J, Tournoux-Facon C, Ducreux D. 2005. MR diffusion tensor imaging and fiber tracking in spinal cord compression. AJNR Am J Neuroradiol 26:1587-1594.
7. Horsfield MA, Lai M, Webb SL, Barker GJ, Tofts PS, Turner R, et al. 1996. Apparent diffusion coefficients in benign and secondary progressive multiple sclerosis by nuclear magnetic resonance. Magn Reson Med 36:393-400.
8. Werring DJ, Clark CA, Barker GJ, Thompson AJ, Miller DH. 1999. Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology 52:1626.
9. Bammer R, Augustin M, Strasser-Fuchs S, Seifert T, Kapeller P, Stollberger R, et al. 2000. Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis. Magn Reson Med 44:583-591.
10. Clark CA, Werring DJ, Miller DH. 2000. Diffusion imaging of the spinal cord in vivo: estimation of the principal diffusivities and application to multiple sclerosis. Magn Reson Med 43:133-138.
11. Sagiuchi T, Tachibana S, Endo M, Hayakawa K. 2002. Diffusion-weighted MRI of the cervical cord in acute spinal cord injury with type II odontoid fracture. J Comput Assist Tomogr 26:654-656.
12. Ellingson BM, Prost RW, Ulmer JL, Schmit BD. 2006. Morphology and morphometry in chronic spinal cord injury assessed using diffusion tensor imaging and fuzzy logic. Conf Proc IEEE Eng Med Biol Soc 1:1885-1888.
13. Ellingson BM, Ulmer JL, Schmit BD. 2006. A new technique for imaging the human spinal cord in vivo. Biomed Sci Instrum 42:255-260.
14. Stejskal EO, Tanner JE. 1965. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 42:288-292.
15. Stejskal EO. 1965. Use of spin echoes in a pulsed magnetic-field gradient to study anisotropic, restricted diffusion and flow. J Chem Phys 43:3597-3603.
16. Le Bihan D, Breton E, Lallemand D, Aubin M, Vignaud J, Laval-Jeantet M. 1988. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497-505.
17. Basser PJ, Mattiello J, LeBihan D. 1994. Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 103:247-254.
18. Basser PJ, Mattiello J, LeBihan D. 1994. MR diffusion tensor spectroscopy and imaging. Biophys J 66:259-267.
19. Lythgoe MF, Busza AL, Calamante F, Sotak CH, King MD, Bingham AC, et al. 1997. Effects of diffusion anisotropy on lesion delineation in a rat model of cerebral ischemia. Magn Reson Med 38: 662-668.
20. Minati L, Weglarz WP. 2007. Physical foundations, models, and methods of diffusion magnetic resonance imaging of the brain: a review. Concepts Magn Reson Part A 30:278-307.
21. Kingsley PB. 2006. Introduction to diffusion tensor imaging mathematics. I. Tensors, rotations, and eigenvectors. Concepts Magn Reson Part A 28:101-122.
22. Kingsley PB. 2006. Introduction to diffusion tensor imaging mathematics. II. Anisotropy, diffusion-weighting factors, and gradient encoding schemes. Concepts Magn Reson Part A 28:123-154.
23. Kingsley PB. 2006. Introduction to diffusion tensor imaging mathematics. III. Tensor calculation, noise, simulations, and optimization. Concepts Magn Reson Part A 28:155-179.
24. Crank J. 1975. The Mathematics of Diffusion. New York: Oxford University Press.
25. Einstein A. 1956. Investigations on the Theory of Brownian Movement. New York: Dover.
26. Kawasaki K. 1970. Kinetic equations and time correlation functions of critical fluctuations. Ann Phys 61:1-56.
27. Hrabe J, Hrabetova S, Segeth K. 2004. A model of effective diffusion and tortuosity in the extracellular space of the brain. Biophys J 87:1606-1617.
28. Nicholson C. 2001. Diffusion and related transport mechanisms in brain tissue. Rep Progr Phys 64:815-884.
29. Nicholson C, Phillips JM. 1981. Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. J Physiol 321:225-257.
30. Bernstein MA, King KF, Zhou XJ. 2004. Handbook of MRI Pulse Sequences. San Diego, CA: Elsevier.
31. Koay CG, Carew JD, Alexander AL, Basser PJ, Meyerand ME. 2006. Investigation of anomalous estimates of tensor-derived quantities in diffusion tensor imaging. Magn Reson Med 55:930-936.
32. Basser PJ. 1995. Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed 8:333-344.
33. Basser PJ, Pierpaoli C. 1996. Microstructural and physiological features of tissues elucidated by quantitative-diffusion tensor MRI. J Magn Reson B 111:209-219.
34. Pierpaoli C, Basser PJ. 1996. Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 36:893-906.
35. Ellingson BM, Ulmer JL, Schmit BD. 2007. Gray and white matter delineation in the human spinal cord using diffusion tensor imaging and fuzzy logic. Acad Radiol 14:847-858.
36. Mori S, van Zijl PC. 2002. Fiber tracking: principles and strategies - a technical review. NMR Biomed 15:468-480.
37. Basser PJ, Pajevic S, Pierpaoli C, Duda JT, Aldroubi A. 2000. In vivo tractography using DTMRI data. Magn Reson Med 39:625-632.
38. Mori S, Crain BJ, Chacko VP, van Zijl PC. 1999. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 45:265-269.
39. Weinstein DM, Kindlmann GL, Lundberg EC. 1999. Tensorlines: Advection-diffusion based propagation through diffusion tensor fields. Proc IEEE Visualization. San Francisco, CA: IEEE Computer Society. pp 249-253.
40. Lazar M, Weinstein D, Hasan K, Alexander AL. 2000. Axon tractography with tensorlines. Proc Intl Soc Mag Reson Med 8:482.
41. Mori S, Kaufmann WE, Davatzikos C, Stieltjes B, Amodei L, Fredericksen K, et al. 2002. Imaging cortical association tracts in human brain. Magn Reson Imaging 47:215-223.
42. Mori S, Davatzikos C, Xu D, Amodei L, Fredericksen K, Solaiyappan M, et al. 2001. A probabilistic map approach for the analysis of DTI-based fiber tracking and its application to white matter injuries. Proc Intl Soc Mag Reson Med 9:1522.
43. Arfanakis K, Gui M, Lazar M. 2006. Optimization of white matter tractography for pre-surgical planning and image-guided surgery. Oncol Rep 15:1061-1064.
44. Yu CS, Li KC, Xuan Y, Ji XM, Qin W. 2005. Diffusion tensor tractography in patients with cerebral tumors: a helpful technique for neurosurgical planning and postoperative assessment. Eur J Radiol 56:197-204.
45. Schwartz ED, Duda JT, Shumsky JS, Cooper ET, Gee JC. 2005. Spinal cord diffusion tensor imaging and fiber tracking can identify white matter tract disruption and glial scar orientation following lateral funiculotomy. J Neurotrauma 22:1388-1398.
46. Thomsen C, Henriksen O, Ring P. 1987. In vivo measurement of water self diffusion in the human brain by magnetic resonance imaging. Acta Radiol 28:353-361.
47. Moseley ME, Cohen Y, Kucharczyk J, Mintorovitch J, Asgari HS, Wendland MF, et al. 1990. Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. Radiology 176:439-445.
48. Pattany PM, Puckett WR, Klose KJ, Quencer RM, Bunge RP, Kasuboski L, et al. 1997. High-resolution diffusion-weighted MR of fresh and fixed cat spinal cords: evaluation of diffusion coefficients and anisotropy. AJNR Am J Neuroradiol 18:1049-1056.
49. Takahashi M, Hackney DB, Zhang G, Wehrli SL, Wright AC, O'Brien W, et al. 2002. Magnetic resonance microimaging of intraaxonal water diffusion in live excised lamprey spinal cord. Proc Nat Acad Sci USA 99:16192-16196.
50. Franconi F, Lemaire L, Marescaux L, Jallet P, Le Jeune JJ. 2000. In vivo quantitative microimaging of rat spinal cord at 7T. Magn Reson Med 44:893-898.
51. Schwartz ED, Cooper ET, Chin CL, Wehrli S, Tessler A, Hackney DB. 2005. Ex vivo evaluation of ADC values within spinal cord white matter tracts. AJNR Am J Neuroradiol 26:390-397.
52. Inglis BA, Yang L, Wirth ED, III, Plant D, Mareci TH. 1997. Diffusion anisotropy in excised normal rat spinal cord measured by NMR microscopy. Magn Reson Imaging 15:441-450.
53. Ford JC, Hackney DB. 1997. Numerical model for calculations of apparent diffusion coefficient (ADC) in permeable cylinders-comparison with measured ADC in spinal cord white matter. Magn Reson Med 37:387-394.
54. Hwang SN, Chin CL, Wehrli FW, Hackney DB. 2003. An image-based finite difference model for simulating restricted diffusion. Magn Reson Med 50:373-382.
55. Stanisz G, Szafer A, Wright GA, Henkelman RM. 1997. An analytical model of restricted diffusion in bovine optic nerve. Magn Reson Med 37:103-111.
56. Schwartz ED, Cooper ET, Fan Y, Jawad AF, Chin CL, Nissanov J, et al. 2005. MRI diffusion coefficients in spinal cord correlate with axon morphometry. Neuroreport 16:73-76.
57. Kinoshita Y, Ohnishi A, Kohshi K, Yokota A. 1999. Apparent diffusion coefficient on rat brain and nerves intoxicated with methylmercury. Environ Res 80:348-354.
58. Ellingson BM, Ulmer JL, Kurpad SN, Schmit BD. 2008. Diffusion tensor magnetic resonance imaging of the neurologically intact human spinal cord. AJNR Am J Radiol (in press).
59. Basser PJ, Pierpaoli C. 1998. A simplified method to measure the diffusion tensor from seven MR images. Magn Reson Med 39:928-934.
60. Clark CA, Barker GJ, Tofts PS. 1999. Magnetic resonance diffusion imaging of the human cervical spinal cord in vivo. Magn Reson Med 41:1269-1273.
61. Bammer R, Herneth AM, Maier SE, Butts K, Prokesch RW, Do HM, et al. 2002. Line scan diffusion imaging of the spine. Proc Intl Soc Mag Reson Med 10.
62. Holder CA, Muthupillai R, Mukundan S, Jr., Eastwood JD, Hudgin PA. 2000. Diffusion-weighted MR imaging of the normal human spinal cord in vivo. AJNR Am J Neuroradiol 21:1799-1806.
63. Cercignani M, Horsfield MA, Agosta F, Filippi M. 2003. Sensitivity-encoded diffusion tensor MR imaging of the cervical cord. AJNR Am J Neuroradiol 24:1254-1256.
64. Bammer R, Keeling SL, Augustin M, Pruessmann KP, Leussler C, Ebner F, et al. 2001. Improved diffusion-weighted single-shot EPI in stroke using SENSE. Proc Intl Soc Mag Reson Med 9:161.
65. Bammer R, Augustin M, Prokesch RW, Stollberger R, Fazekas F. 2002. Diffusion-weighted imaging of the spinal cord: interleaved echo-planar imaging is superior to fast spin-echo. J Magn Reson Imaging 15:364-373.
66. Ellingson BM, Ulmer JL, Schmit BD. 2008. Morphology and morphometry of human chronic spinal cord injury using diffusion tensor imaging and fuzzy logic. Ann Biomed Eng 36:224-236.
67. Inglis BA, Bossart EL, Buckley DL, Wirth ED, III, Mareci TH. 2001. Visualization of neural tissue water compartments using biexponential diffusion tensor MRI. Magn Reson Med 45:580-587.
68. Schwarcz A, Bogner P, Meric P, Correze J, Berente Z, Pal J, et al. 2004. The existance of biexponential signal decay in magnetic resonance diffusion-weighted imaging appears to be independent of compartmentalization. Magn Reson Med 51:278-285.
69. Andrews TJ, Osborne MT, Does MD. 2006. Diffusion of myelin water. Magn Reson Med 56:381-385.
70. Shi R, Pryor JD. 2002. Pathological changes of isolated spinal cord axons in response to mechanical stretch. Neuroscience 110:765-777.
71. Ford JC, Hackney DB, Alsop DC, Jara H, Joseph PM, Hand CM, et al. 1994. MRI characterization of diffusion coefficients in a rat spinal cord injury model. Magn Reson Med 31:488-494.
72. Deo AA, Grill RJ, Hasan K, Narayana PA. 2006. In vivo serial diffusion tensor imaging of experimental spinal cord injury. J Neurosci Res 83:801-810.
73. Ford JC, Hackney DB, Lavi E, Phillips M, Patel U. 1998. Dependence of apparent diffusion coefficients on axonal spacing, membrane permeability, and diffusion time in spinal cord white matter. J Magn Reson Imaging 8:775-782.
74. Ducker TB, Saleman M, Perot PL, Balentine D. 1978. Experimental spinal cord trauma. I. Correlation of blood flow, tissue oxygen, and neurologic status in the dog. Surg Neurol 10:60-63.
75. Holtz A, Nystrom B, Gerdin B. 1989. Spinal cord blood flow measured by 14C-iodoantipyrine autoradiography during and after graded spinal cord compression in rats. Surg Neurol 31:350-360.
76. Rivlin AS, Tator CH. 1978. Regional spinal cord blood flow in rats after severe cord trauma. J Neurosurg 49:470-477.
77. Hayashi N, De La Torre JC, Green BA. 1980. Regional spinal cord blood flow and tissue oxygen content after spinal cord trauma. Surg Forum 31:461-463.
78. Stokes BT, Garwood M, Walters P. 1981. Oxygen fields in specific spinal loci of the canine spinal cord. Am J Physiol 240:H761-H766.
79. Schwab ME, Bartholdi D. 1996. Degeneration and regeneration of axons in the lesioned spinal cord. Physiol Rev 76:319-370.
80. Walker JG, Yates RR, Yashon D. 1979. Regional canine spinal cord energy state after experimental trauma. J Neurochem 33:397-401.
81. Anderson DK, Means ED, Waters TR, Spears CJ. 1980. Spinal cord energy metabolism following compression trauma to the feline spinal cord. J Neurosurg 53:375-380.
82. Sun S, Liang H, Le T, Armstrong RC, Cross AH, Song S. 2006. Differential sensitivity of in vivo and ex vivo diffusion tensor imaging to evolving optic nerve injury in mice with retinal ischemia. Neuroimage 32:1195-1204.
83. Drobyshevsky A, Derrick M, Wyrwicz AM, Ji X, Englof I, Ullman LM, et al. 2007. White matter injury correlates with hypertonia in an animal model of cerebral palsy. J Cereb Blood Flow Metab 27:270-281.
84. Bammer R, Fazekas F, Augustin M, Simbrunner J, Strasser-Fuchs S, Seifert T, et al. 2000. Diffusion-weighted MR imaging of the spinal cord. AJNR Am J Neuroradiol 21:587-591.
85. Kuker W, Weller M, Klose U, Krapf H, Dichgans J, Nagele T. 2004. Diffusion-weighted MRI of spinal cord infarction-high resolution imaging and time course of diffusion abnormality. J Neurol 251:818-824.
86. Thomalla G, Glauche V, Weiller C, Rother J. 2006. Time course of wallerian degeneration after ischaemic stroke revealed by diffusion tensor imaging. J Neurol Neurosurg Psychiatry 76:266-268.
87. Haku T, Miyasaka N, Kuroiwa T, Kubota T, Aso T. 2006. Transient ADC change precedes persistent neuronal death in hypoxic-ischemic model in immature rats. Brain Res 1100:136-141.
88. Sandler AN, Tator CH. 1976. Review of the effect of spinal cord trauma on the vessels and blood flow in the spinal cord. J Neurosurg 45:638-646.
89. Wagner FC, Jr., Dohrmann GJ, Bucy PC. 1971. Histopathology of transitory traumatic paraplegia in the monkey. J Neurosurg 35:272-276.
90. Hagg T, Oudega M. 2006. Degenerative and spontaneous regenerative processes after spinal cord injury. J Neurotrauma 23:264-280.
91. Balentine JD. 1978. Pathology of experimental spinal cord trauma. Lab Invest 39:236-253.
92. Mautes AE, Weinzierl MR, Donovan F, Noble LJ. 2000. Vascular events after spinal cord injury: contribution to secondary pathogenesis. Phys Ther 80:673-687.
93. Schwartz ED, Hackney DB. 2003. Diffusion-weighted MRI and the evaluation of spinal cord axonal integrity following injury and treatment. Exp Neurol 184:570-589.
94. Chin CL, Wehrli FW, Hwang SN, Takahashi M, Hackney DB. 2002. Biexponential diffusion attenuation in the rat spinal cord: computer simulations based on anatomic images of axonal architecture. Magn Reson Med 47:455-460.
95. Niendorf T, Dijkhuizen R, Norris DG,van Lookeren Campagne M, Nicolay K. 1996. Biexponential diffusion attenuation in various states of brain tissue: implications for diffusion weighted imaging. Magn Reson Med 36:847-857.
96. Andersson PB, Perry VH, Gordon S. 1991. The kinetic and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration. Neuroscience 42:201-214.
97. Dusart I, Schwab ME. 1994. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur J Neurosci 6:712-724.
98. Norton WT, Aquino DA, Hozumi I, Chiu FC, Brosnan CF. 1992. Quantitative aspects of reactive gliosis: a review. Neurochem Res 17:877-885.
99. Barrett CP, Guth L, Donati EJ, Krikorian JG. 1981. Astroglial reaction in gray matter of lumbar segments after midthoracic transection of the adult rat spinal cord. Exp Neurol 73:365-377.
100. Blakemore WF. 1975. Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the rat. J Neurocytol 4:745-757.
101. Waller A. 1850. Experiments on the section of glossopharyngeal and hypoglossal nerves of the frog and observation of the alternatives produced thereby in the structure of their primative fibres. Phil Trans R Soc Lond 140:423.
102. Fishman PS, Kelley JP. 1984. The fate of severed corticospinal axons. Neurology 34:1161-1167.
103. Pallini R, Fernandez E, Sbriccoli A. 1988. Retrograde degenerations of corticospinal axons following transection of the spinal cord in rats. J Neurosurg 68:124-128.
104. Ramon Y, Cajal S. 1928. Degeneration and Regeneration of the Nervous System. London: Oxford University Press.
105. Kalil K, Schneider GE. 1975. Retrograde cortical and axonal changes following lesions of the pyramidal tract. Brain Res 89:15-27.
106. Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. 1997. Apoptosis and delayed degeneration after spinal cord injur in rats and monkeys. Nat Med 3:240.
107. Young W, Koreh I. 1986. Potassium and calcium changes in injured spinal cords. Brain Res 365:42-53.
108. Moriya T, Hassan AZ, Young W, Chesler M. 1994. Dynamics of extracellular calcium activity following contusion of the rat spinal cord. J Neurotrauma 11:255-263.
109. Schwartz ED, Chin CL, Shumsky JS, Jawad AF, Brown BK, Wehrli S, et al. 2005. Apparent diffusion coefficients in spinal cord transplants and surrounding white matter correlate with degree of axonal dieback after injury in rats. AJNR Am J Neuroradiol 26:7-18.
110. Kitzman P. 2005. Alterations in axial motoneuron morphology in the spinal cord injured spastic cat. Exp Neurol 192:100-108.
111. Finnerup NB, Gyldensted C, Nielsen E, Kristensen AD, Bach FW, Jensen TS. 2003. MRI in chronic spinal cord injury patients with and without central pain. Neurology 61:1569-1575.
112. Uchida K, Baba H, Maezawa Y, Furukawa S, Furukawa N, Imura S. 1998. Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): morphological changes in anterior horn cells and immunoreactivity to neurotropic factors. J Neurol 245:781-793.
113. Ford JC, Hackney DB, Joseph PM, Phelan M, Alsop DC, Tabor SL, et al. 1994. A method for in vivo high resolution MRI of rat spinal cord injury. Magn Reson Med 31:218-223.
114. Fraidakis M, Klason T, Cheng H, Olson L, Spenger C. 1998. High-resolution MRI of intact and transected rat spinal cord. Exp Neurol 153:299-312.
115. Totoiu MO, Keirstead HS. 2005. Spinal cord injury is accompanied by chronic progressive demyelination. J Comp Neurol 486:373-383.
116. Waxman SG. 1989. Demyelination in spinal cord injury. J Neurol Sci 91:1-14.
117. Bunge RP, Pucket WR, Becerra JL, Marcillo A, Quencer RM. 1993. Observation on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination. Adv Neurol 59:75-89.
118. Blakemore WF. 1974. Pattern of remyelination in the CNS. Nature 249:577-578.
119. Blight AR, Decrescito V. 1986. Morphometric analysis of experimental spinal cord injury in the cat: the relation of injury intensity to survival of myelinated axons. Neuroscience 19:321-341.
120. Harrison BM, McDonald WI. 1977. Remyelination after transient experimental compression of the spinal cord. Ann Neurol 1:542-551.
121. Ito T, Oyanagi K, Wakabayashi K, Ikuta F. 1997. Traumatic spinal cord injury: a neuropathological study on the longitudinal spreading of the lesions. Acta Neuropathol (Berlin) 93:13-18.
122. Valsasina P, Rocca MA, Agosta F, Benedetti B, Horsfield MA, Gallo A, et al. 2005. Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients. Neuroimage 26:822-828.
123. Agosta F, Rovaris M, Benedetti B, Valsasina P, Filippi M. 2004. Diffusion tensor MRI of the cervical cord in a patient with syringomyelia and multiple sclerosis. J Neurol Neurosurg Psychiatry 75:1647.
124. Schneider JF, Il'yasov KA, Boltshauser E, Henning J, Martin E. 2003. Diffusion tensor imaging in cases of adrenoleukodystrophy: preliminary experience as a marker for early demyelination? AJNR Am J Neuroradiol 24:819-824.
125. Summers P, Staempfli P, Jaermann T, Kwiecinski S, Kollias S. 2006. A preliminary study of the effects of trigger timing on diffusion tensor imaging of the human spinal cord. AJNR Am J Neuroradiol 27:1952-1961.
126. Ordidge RJ, Helpern JA, Qing ZQ, Knight RA, Nagesh V. 1994. Correction of motion artifacts in diffusion-weighted MR images using navigator echoes. Magn Reson Imaging 12:455-460.
127. Mikulis DJ, Wood ML, Zerdoner OAM, Poncelet BP. 1994. Oscillatory motion of the normal cervical spinal cord. Radiology 192:117-121.
128. Ries M, Jones RA, Dousset V, Moonen CT. 2000. Diffusion tensor MRI of the spinal cord. Magn Reson Med 44:884-892.
129. Jezzard P, Balaban RS. 1995. Correction for geometric distortion in echo planar images from B0 field variations. Magn Reson Med 34:65-73.
130. Papadakis NG, Smponias T, Berwick J, Mayhew J. 2005. k-Space correction of eddy-current-induced distortions in diffusion-weighted echo-planar imaging. Magn Reson Med 53:1103-1111.
131. Reese TG, Heid O, Weisskoff RM, Wedeen VJ. 2003. Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo. Magn Reson Med 49:177-182.
132. Cooke FJ, Blamire AM, Manners DN, Styles P, Rajagopalan B. 2004. Quantitative proton magnetic resonance spectroscopy of the cervical spinal cord. Magn Reson Med 51:1122-1128.
133. ASIA (American Spinal Injury Association). 2006. Standard Neurological Classification of Spinal Cord Injury. http://www.asia-spinalinjury.org.
134. Dobkin B, Apple D, Barbeau H, Basso M, Behrman A, Deforge D, et al. 2006. Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI. Neurology 66:484-493.
135. Waters RL, Adkins RH, Yakura JS, Sie I. 1994. Motor and sensory recovery following incomplete tetraplegia. Arch Phys Med Rehabil 75:306-311.
136. Price SJ, Pena A, Burnet NG, Jena R, Green HA, Carpenter TA, et al. 2004. Tissue signature characterization of diffusion tensor abnormalities in cerebral gliomas. Eur Radiol 14:1909-1917.
137. Tropine A, Vucurevic G, Delani P, Boor S, Hopf N, Bohl J, et al. 2004. Contribution of diffusion tensor imaging to delineation of gliomas and glioblastomas. J Magn Reson Imaging 20:905-912.
138. Beppu T, Inoue T, Shibata Y, Yamada N, Kurose A, Ogasawara K, et al. 2005. Fractional anisotropy value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas. Surg Neurol 63:56-61.
139. Misaki T, Beppu T, Inoue T, Ogasawara K, Ogawa A, Kabasawa H. 2004. Use of fractional anisotropy value by diffusion tensor MRI for preoperative diagnosis of astrocytic tumors: case report. J Neurooncol 70:343-348.
140. Ulmer JL, Salvan CV, Mueller WM, Krouwer HG, Stroe GO, Aralasmak A, et al. 2004. The role of diffusion tensor imaging in establishing the proximity of tumor borders to functional brain systems: implications for preoperative risk assessments and postoperative outcomes. Technol Cancer Res Treat 3:567-576.
141. Fehlings MG, Perrin RG. 2006. The timing of surgical intervention in the treatment of spinal cord injury: a systematic review of recent clinical evidence. Spine 31:S28-S35 (Review).
142. Dietrich WD, Chatzipanteli K, Vitarbo E, Wada K, Kinoshita K. 2004. The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma. Acta Neurochirurgica 89:69-74.
143. Hurlbert RJ. 2006. Strategies of medical intervention in the management of acute spinal cord injury. Spine 31:S16-S21 (Review).
144. Nevo U, Hauben E, Yoles E, Agranov E, Alkselrod S, Schwartz M, et al. 2001. Diffusion anisotropy MRI for quantitative assessment of recovery in the rat spinal cord. Magn Reson Med 45:1-9.
145. Berman SA, Young RR, Sarkarati M, Shefner JM. 1996. Injury zone denervation in traumatic quadriplegia in humans. Muscle Nerve 19:701-706.
146. Mulcahey MJ, Smith BT, Betz RR. 1999. Evaluation of the lower motor neuron integrity of upper extremity muscles in high level spinal cord injury. Spinal Cord 37:585-591.