Pathological changes of isolated spinal cord axons in response to mechanical stretch

Neuroscience

Volumn 110, Issue 4, 2002, Pages 765-777

  Shi, R ^a   Pryor, J D ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Axon; Elongation; Membrane sealing; Nerve repair; Neurotrauma; Spinal cord injury

Indexed keywords

4 AMINOPYRIDINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SUCROSE;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MONITORING; CONTROLLED STUDY; DETERIORATION; DISEASE SEVERITY; ELECTRIC POTENTIAL; ENZYME ASSAY; FEMALE; GUINEA PIG; IN VITRO STUDY; INJURY; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; MORPHOLOGY; MYELIN SHEATH; MYELINATED NERVE; NERVE FIBER; NONHUMAN; PATHOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; SPECTRUM; SPINAL CORD; STIMULUS RESPONSE; SURFACE PROPERTY; TECHNIQUE; WHITE MATTER;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; AXONS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; DISEASE MODELS, ANIMAL; FEMALE; GUINEA PIGS; MYELIN SHEATH; NERVE DEGENERATION; NERVE FIBERS, MYELINATED; NEURAL CONDUCTION; POTASSIUM CHANNEL BLOCKERS; REACTION TIME; SPINAL CORD; SPINAL CORD INJURIES; STRESS, MECHANICAL;

EID: 0037012448     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00596-6     Document Type: Article

References (31)

1. Mechanisms of secondary injury to spinal cord axons in vitro: Role of Na+, Na(+)-K(+)-ATPase, the Na(+)-H+ exchanger, and the Na(+)-Ca2+ exchanger
2. Dynamic stretch correlates to both morphological abnormalities and electrophysiological impairments in a model of traumatic axonal injury
3. A quantitative study of electrical stimulation of central myelinated fibers
4. Mechanical factors in experimental spinal cord injury
5. Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury
6. Morphometric analysis of a model of spinal cord injury in guinea-pigs, with behavioral evidence of delayed secondary pathology
7. Morphometric analysis of experimental spinal cord injury in the cat: The relation of injury intensity to survival of myelinated axons
8. The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice
9. A new model for rapid stretch-induced injury of cells in culture: Characterization of the model using astrocytes
10. Mechanical and electrical responses of the squid giant axon to simple elongation
11. Effects of ischemia-like conditions on cultured neurons:protection by low Na+, low Ca2+ solutions
12. Electrogenic pump (Na+/K(+)-ATPase) activity in rat optic nerve
13. Different effects of 4-aminopyridine on sensory and motor fibers: Pathogenesis of paresthesias
14. Focal axonal injury: The early axonal response to stretch
15. Traumatically induced altered membrane permeability: Its relationship to traumatically induced reactive axonal change
16. Reduction of NaCl increases survival of mammalian spinal neurons subjected to dendrite transection injury
17. Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury
18. Control of membrane sealing in injured mammalian spinal cord axons
19. Compression injury of mammalian spinal cord in vitro and the dynamics of action potential conduction failure
20. Differential effects of low and high concentrations of 4-aminopyridine on axonal conduction in normal and injured spinal cord
21. Acute repair of crushed guinea-pig spinal cord by polyethylene glycol
22. Anatomical repair of nerve membrane in crushed mammalian spinal cord with polyethylene glycol
23. Conduction block in acute and chronic spinal cord injury: Different dose-response characteristics for reversal by 4-aminopyridine
24. Temperature dependence of membrane sealing following transection in mammalian spinal cord axons
25. High tolerance and delayed elastic response of cultured axons to dynamic stretch injury
26. Na+-Ca2+ exchange mediates Ca2+ influx during anoxia in mammalin central nervous system white matter
27. Ionic mechanisms of anoxic injury in mammalian CNS white matter:role of Na+ channels and Na+-Ca2+ exchanger
28. Local blockade of sodium channels by tetrodotoxin ameliorates tissue loss and long-term functional deficits resulting from experimental spinal cord injury
29. Non-synaptic mechanisms of Ca2+-mediated injury in CNS white matter
30. Strength-duration characteristics of myelinated and non-myelinated bulbospinal axons in the cat spinal cord