The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: A retrospective cohort study

BMC Infectious Diseases

Volumn 8, Issue , 2008, Pages

  Huang, Lyen C ^a   Myer, Landon ^a,b   Jaspan, Heather B ^c,d  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b Mailman School of Public Health   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN; AMPICILLIN; ANTIRETROVIRUS AGENT; CEFOTAXIME; FLUCONAZOLE; IMMUNOGLOBULIN; PIPERACILLIN PLUS TAZOBACTAM; TUBERCULOSTATIC AGENT; VANCOMYCIN;

ADJUVANT THERAPY; ANTIBIOTIC THERAPY; ANTIVIRAL THERAPY; ARTICLE; BACTERIAL INFECTION; BACTERIAL MENINGITIS; BLOOD CULTURE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FAILURE TO THRIVE; FEMALE; GASTROENTERITIS; GENDER; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; LENGTH OF STAY; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRESCHOOL CHILD; REPEATED DRUG DOSE; SEPSIS; SINGLE DRUG DOSE; TREATMENT OUTCOME; TUBERCULOSIS; URINARY TRACT INFECTION; BACTEREMIA; DRUG EFFECT; HOSPITAL; HUMAN IMMUNODEFICIENCY VIRUS; RETROSPECTIVE STUDY; SOUTH AFRICA; STATISTICAL MODEL;

BACTEREMIA; BACTERIAL INFECTIONS; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; HIV; HIV INFECTIONS; HOSPITALS, URBAN; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INFANT; LENGTH OF STAY; LOGISTIC MODELS; MALE; RETROSPECTIVE STUDIES; SOUTH AFRICA; TREATMENT OUTCOME;

EID: 54949125937     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-8-127     Document Type: Article

References (32)

1. UNAIDS/WHO UNAIDS/WHO AIDS Epidemic Update: December 2006 Geneva, Switzerland: UNAIDS/WHO 2006 http://www.unaids.org/en/KnowledgeCentre/ HIVData/EpiUpdate/EpiUpdArchive/2006/Default.asp
2. South African Department of Health National HIV and Syphilis Antenatal Sero-prevalence Survey in South Africa 2005 Pretoria: South African Department of Health 2005 http://www.doh.gov.za/docs/reports/2005/hiv.pdf
3. Krug A Pattinson RC Power DJ Why children die: An under-5 health care survey in Mafikeng region S Afr Med J 2004, 94:202-206. 15098281
4. Jones N Huebner R Khoosal M Crewe-Brown H Klugman K The impact of HIV on Streptococcus pneumoniae bacteraemia in a South African population AIDS 1998, 12:2177-2184. 10.1097/00002030-199816000-00013 9833859
5. Madhi SA Petersen K Madhi A Khoosal M Klugman KP Increased disease burden and antibiotic resistance of bacteria causing severe community-acquired lower respiratory tract infections in human immunodeficiency virus type 1-infected children Clin Infect Dis 2000, 31:170-176. 10.1086/313925 10913417
6. Meyers TM Pettifor JM Gray GE Crewe-Brown H Galpin JS Pediatric admissions with human immunodeficiency virus infection at a regional hospital in Soweto, South Africa J Trop Pediatr 2000, 46:224-230. 10.1093/tropej/46.4.224 10996984
7. Kumar A Teuber SS Gershwin ME Intravenous immunoglobulin: Striving for appropriate use Int Arch Allergy Immunol 2006, 140:185-198. 10.1159/ 000093204 16682800
8. Dalakas MC Mechanisms of action of IVIg and therapeutic considerations in the treatment of acute and chronic demyelinating neuropathies Neurology 2002, 59:S13-S21. 12499466
9. Lemieux R Bazin R Néron S Therapeutic intravenous immunoglobulins Mol Immunol 2005, 42:839-848. 10.1016/j.molimm.2004.07.046 15829272
10. NICHD Intravenous immune globulin for the prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection. The National Institute of Child Health and Human Developments Intravenous Immunoglobulin Study Group N Engl J Med 1991, 325:73-80. 1675763
11. Spector SA Gelber RD McGrath N Wara D Barzilai A Abrams E Bryson YJ Dankner WM Livingston RA Connor EM A controlled trial of intravenous immune globulin for the prevention of serious bacterial infections in children receiving zidovudine for advanced human immunodeficiency virus infection. Pediatric AIDS Clinical Trials Group N Engl J Med 1994, 331:1181-1187. 10.1056/NEJM199411033311802 7935655
12. El-Nawawy A El-Kinany H Hamdy El-Sayed M Boshra N Intravenous polyclonal immunoglobulin administration to sepsis syndrome patients: A prospective study in a pediatric intensive care unit J Trop Pediatr 2005, 51:271-278. 10.1093/tropej/fmi011 15917261
13. Ohlsson A Lacy JB Intravenous immunoglobulin for suspected or subsequently proven infection in neonates Cochrane Database Syst Rev 2004:CD001239. 14973965
14. Jenson HB Pollock BH Meta-analyses of the effectiveness of intravenous immune globulin for prevention and treatment of neonatal sepsis Pediatrics 1997, 99:E2. 10.1542/peds.99.2.e2 9099759
15. Pildal J Gøtzsche PC Polyclonal immunoglobulin for treatment of bacterial sepsis: A systematic review Clin Infect Dis 2004, 39:38-46. 10.1086/421089 15206051
16. Alejandria MM Lansang MA Dans LF Mantaring JB Intravenous immunoglobulin for treating sepsis and septic shock Cochrane Database Syst Rev 2002:CD001090. 11869591
17. Stiehm ER Shortage of IV immunoglobulin Ann Allergy Asthma Immunol 2000, 85:424. 11101191
18. Milgrom H Shortage of intravenous immunoglobulin Ann Allergy Asthma Immunol 1998, 81:97-100. 9723552
19. Pollack MM Patel KM Ruttimann UE PRISM III: An updated Pediatric Risk of Mortality score Crit Care Med 1996, 24:743-752. 10.1097/ 00003246-199605000-00004 8706448
20. Shearer WT Easley KA Goldfarb J Rosenblatt HM Jenson HB Kovacs A McIntosh K Prospective 5-year study of peripheral blood CD4, CD8, and CD19/CD20 lymphocytes and serum Igs in children born to HIV-1 women. The P(2)C(2) HIV Study Group J Allergy Clin Immunol 2000, 106:559-566. 10.1067/mai.2000.109433 10984378
21. Arango CA Midani S Alvarez A Kubilis PS Rathore MH Usefulness of acute phase reactants in the diagnosis of acute infections in HIV-infected children South Med J 1999, 92:209-213. 10.1097/00007611-199902000-00009 10071669
22. Waibale P Bowlin SJ Mortimer EA Whalen C The effect of human immunodeficiency virus-1 infection and stunting on measles immunoglobulin-G levels in children vaccinated against measles in Uganda Int J Epidemiol 1999, 28:341-346. 10.1093/ije/28.2.341 10342701
23. Gibb D Giacomelli A Masters J Spoulou V Ruga E Griffiths H Kroll S Giaquinto C Goldblatt D Persistence of antibody responses to Haemophilus influenzae type b polysaccharide conjugate vaccine in children with vertically acquired human immunodeficiency virus infection Pediatr Infect Dis J 1996, 15:1097-1101. 10.1097/00006454-199612000-00008 8970219
24. Lederman HM Williams PL Wu JW Evans TG Cohn SE McCutchan JA Koletar SL Hafner R Connick E Valentine FT McElrath MJ Roberts NJ Currier JS AIDS Clinical Trials Group 889 Study Team Incomplete immune reconstitution after initiation of highly active antiretroviral therapy in human immunodeficiency virus-infected patients with severe CD4+ cell depletion J Infect Dis 2003, 188:1794-1803. 10.1086/379900 14673757
25. Koleba T Ensom MH Pharmacokinetics of intravenous immunoglobulin: A systematic review Pharmacotherapy 2006, 26:813-827. 10.1592/ phco.26.6.813 16716135
26. Mofenson LM Moye J Intravenous immune globulin for the prevention of infections in children with symptomatic human immunodeficiency virus infection Pediatr Res 1993, 33:S80-7. discussion S87-9 10.1203/ 00006450-199304001-00015 8433880
27. Blomberg B Manji KP Urassa WK Tamim BS Mwakagile DS Jureen R Msangi V Tellevik MG Holberg-Petersen M Harthug S Maselle SY Langeland N Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: A prospective cohort study BMC Infect Dis 2007, 7:43. 1891109 17519011 10.1186/1471-2334-7-43
28. Amadi B Kelly P Mwiya M Mulwazi E Sianongo S Changwe F Thomson M Hachungula J Watuka A Walker-Smith J Chintu C Intestinal and systemic infection, HIV, and mortality in Zambian children with persistent diarrhea and malnutrition J Pediatr Gastroenterol Nutr 2001, 32:550-554. 10.1097/00005176-200105000-00011 11429515
29. Kessler L Daley H Malenga G Graham S The impact of the human immunodeficiency virus type 1 on the management of severe malnutrition in Malawi Ann Trop Paediatr 2000, 20:50-56. 10.1080/02724930092075 10824214
30. Heikens GT How can we improve the care of severely malnourished children in Africa? PLoS Med 200,7 4:e45. 1783670 17326705 10.1371/ journal.pmed.0040045
31. Deen JL Funk M Guevara VC Saloojee H Doe JY Palmer A Weber MW Implementation of WHO guidelines on management of severe malnutrition in hospitals in Africa Bull World Health Organ 2003, 81:237-243. 12764489
32. Gardulf A Immunoglobulin treatment for primary antibody deficiencies: advantages of the subcutaneous route BioDrugs 2007 21 105 116 10.2165/ 00063030-200721020-00005 17402794