Intravenous polyclonal immunoglobulin administration to sepsis syndrome patients: A prospective study in a pediatric intensive care unit

Journal of Tropical Pediatrics

Volumn 51, Issue 5, 2005, Pages 271-278

  El Nawawy, Ahmed ^a,c   El Kinany, Hassan ^a   El Sayed, Mona Hamdy ^b   Boshra, Nevine ^a  

^a Alexandria University ^*  (Egypt)

^b ALEXANDRIA UNIVERSITY   (Egypt)

^c NONE   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; C REACTIVE PROTEIN; ELECTROLYTE; IMMUNOGLOBULIN G; OXYGEN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BLOOD CULTURE; BLOOD EXAMINATION; BLOOD GAS ANALYSIS; BLOOD SAMPLING; CEREBROSPINAL FLUID CULTURE; CHILD; CHILD HEALTH CARE; CHILDHOOD MORTALITY; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG DOSE REGIMEN; FECES CULTURE; FEMALE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; HUMAN CELL; INFANT; INFECTION COMPLICATION; INTENSIVE CARE UNIT; KIDNEY FUNCTION TEST; LABORATORY TEST; LENGTH OF STAY; LIVER FUNCTION TEST; LOGISTIC REGRESSION ANALYSIS; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; NEWBORN; OUTCOMES RESEARCH; PATIENT REFERRAL; PREDICTION; PROSPECTIVE STUDY; SCORING SYSTEM; SEPSIS; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; SURVIVAL; URINE CULTURE; WARD;

CASE-CONTROL STUDIES; EGYPT; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; LOGISTIC MODELS; MALE; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 27144491108     PISSN: 01426338     EISSN: 14653664     Source Type: Journal    
DOI: 10.1093/tropej/fmi011     Document Type: Article

References (28)

1. Segedin E. Epidemiology of severe illness in childhood. In: Macnab A, Macrae D, Henning R (eds), Care of the Critically Ill Child. Churchill Livingston, London, 1999; 12-23.
2. Warick B. Septic shock. Pediatr Clin N Amer 2001; 48: 601-24.
3. Brun C, Doyan F, Carlet J, et al. Incidence, risk factors and outcome of severe sepsis and septic shock. JAMA 1995; 247: 968-74.
4. Levy M, Fink M, Marshall J, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intens Care Med 2003; 29: 528-38.
5. Von Rosentiel N, Von Rosentiel I, Adam D. Management of sepsis and septic shock in infants and children. Pediatric Drugs 2001; 3: 9-27.
6. Anderson R, Blumer L. Advances in the therapy for sepsis in children. Pediatr Clin N Amer 1997; 44: 179-206.
7. Tugrul S, Ozean PE, Akinci O, et al. The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis. Crit Care 2002; 6: 357-62.
8. Carlet J. Immunological therapy in sepsis: Currently available. Int Care Med 2001; 27: S93-S103.
9. Rieben R, Roos A, Muzert Y, Tinguely C, Gerristen A, Daha M. Immunoglobulin M-enriched human intravenous immunoglobulin prevents complement activation in vitro and in vivo in a rat model of acute inflammation. Blood 1999; 93: 942-51.
10. Hamill V, Drizd A, Johnson L, et al. NCSH growth curves for children, birth-18 years. United States Vital Health Statistics 1977; 1-IV, 74.
11. Pollack M, Patel M, Ruttimann E. Prism III: An updated pediatric risk of mortality score. Crit Care Med 1996; 24: 743.
12. Alejandria MM, Lansang MA, Dans LF, Mantaring JB. Intravenous immunoglobulin for treating of sepsis and septic shock. Cochrane Database Syst Rew 2002; 2: CD001090.
13. Bojic I, Begovic V, Trnjak Z, Dokic M. The significance of immunoglobulin in the treatment of patients with sepsis and septic shock. Vojnosanit Pregl 1998; 55 (2 Suppl): 75-8.
14. Bellanti J, Zeligas B, Pung Y. Immunology of foetus and newborn. In: Avery G, Fletcher M, Mac Donald M (eds), Neonatology Pathophysiology and Management of the Newborn, 5th edn. Churchill Livingston, New York, 1999; 1093-121.
15. Janeway C, Travers P, Capro J, Walport M. The humoral immune response. In: Janeway C, Travers P, Capro J, Walport M (eds), Immunology, the immune system in health and disease, 4th edn. Churchill Livingston, New York, 1999; 307-60.
16. Grabay C, Kusher I. Acute phase proteins and other system responses to inflammation. N Eng J Med 1999; 340: 448-54.
17. Braun J, Stiehm R. The B-lymphocyte system. In: Stiehm R (ed.), Immunologic Disorders in Infants and Children, 4th edn. W B Saunders, New York, 1996; 3: 35-67.
18. Strait R, Kelly K, Kwrup V. Tumor necrosis factor-α, Interleukin-1 and Interleukin-6 levels in febrile young children with or without occult bacteremia. Pediatrics 1999; 104: 1321-26.
19. Adamik B, Zimecki M, Wlasezyk A, Kubler A. Immunological status of septic and trauma patients. I. High tumor necrosis factor alpha serum levels in septic and trauma patients are not responsible for increased mortality; a prognostic value of serum interleukin 6. Arch Immunol Ther Exp (Warsz) 1997; 45: 350.
20. Janeway C, Travers P, Capro J, Walport M. Host defense against infection. In: Janeway C, Travers P, Capro J, Walport M (eds), Immunology, the immune system in health and disease, 4th edn. Churchill Livingston, New York, 1999; 363-415.
21. Werdan K. Pathophysiology of septic shock and multiple organ dysfunction syndrome and various therapeutic approaches with special emphasis on immunoglobulins. Ther Apher 2001; 5: 115-22.
22. Haque K, Remo C, Bahakim H. Comparison of two types of intravenous immunoglobulins in the treatment of neonatal sepsis. Clin Exp Immunol 1995; 101: 328-33.
23. Maryellen C, Richard S. Immune deficiency disorders. In: Richard S (ed.), Immunologic Disorders in Infants and Children, 4th edn. W B Saunders, Philadelphia, 1996; Vol. 9: 201-52.
24. Walczak H. Tumoricidal activity of TNF related apoptosis inducing ligand in vivo. Nat Med 1999; 5: 157-62.
25. Kyono W, Coates TD. A practical approach to neutrophil disorders. Pediatr Clin N Am 2002; 49: 929-71.
26. Nairn R. Immunology. In: Brooks G, Butel J, Morse S (eds), Medical Microbiology, 22nd edn. Lange Medical Books/McGraw Hill, New York, 2000; 109-32.
27. Hermiston ML, Mentzer WC. A practical approach to the evaluation of the anemic child. Pediatr Clin N Am 2002; 49: 877-91.
28. Lanzkowsky P. Hematologic manifestations of systemic illness. In: Lanzkowsky P (ed.), Manual of Pediatric Hematology and Oncology, 3rd edn. Academic Press, New York, 1999; 73-91.