Sublingual immunotherapy: The quest for innovative adjuvants

Clinical and Experimental Allergy

Volumn 38, Issue 11, 2008, Pages 1705-1706

  Goldman, M ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ANTIALLERGIC AGENT; CHOLERA TOXIN B SUBUNIT; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; PAM3CSK4; PHOSPHORYL LIPID A; RECOMBINANT ALLERGEN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ALLERGIC RHINITIS; CELLULAR IMMUNITY; CLINICAL FEATURE; COST BENEFIT ANALYSIS; CYTOKINE PRODUCTION; DENDRITIC CELL; EDITORIAL; HEALTH CARE COST; HUMAN; IMMUNOTHERAPY; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; SUBLINGUAL IMMUNOTHERAPY; TREATMENT OUTCOME;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, SUBLINGUAL; ANIMALS; CYTOKINES; DENDRITIC CELLS; DESENSITIZATION, IMMUNOLOGIC; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; LIPOPEPTIDES; RESPIRATORY HYPERSENSITIVITY; T-LYMPHOCYTE SUBSETS; TOLL-LIKE RECEPTORS;

EID: 54849435858     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2008.03090.x     Document Type: Editorial

References (18)

1. Cox LS, Linnemann DL, Nolte H, Weldon D, Finegold I, Nelson HS. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol 2006 117 : 1021 35.
2. Frew AJ. Sublingual immunotherapy. N Engl J Med 2008 358 : 2259 64.
3. Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 2005 60 : 4 12.
4. van Wijk RG. Sublingual immunotherapy in children. Expert Opin Biol Ther 2008 8 : 291 8.
5. O'Hehir RE, Sandrini A, Anderson GP, Rolland JM. Sublingual allergen immunotherapy: immunological mechanisms and prospects for refined vaccine preparation. Curr Med Chem 2007 14 : 2235 44.
6. Sun JB, Czerkinsky C, Holmgren J. Sublingual 'oral tolerance' induction with antigen conjugated to cholera toxin B subunit generates regulatory T cells that induce apoptosis and depletion of effector T cells. Scand J Immunol 2007 66 : 278 86.
7. Lombardi V, Van Overtvelt L, Horiot S et al. The TLR2 agonist Pam3CSK4 enhances the induction of antigen-specific tolerance via the sublingual route. Clin Exp Allergy 2008 38 doi :).
8. Goriely S, Neurath MF, Goldman M. How microorganisms tip the balance between interleukin-12 family members. Nat Rev Immunol 2008 8 : 81 6.
9. Re F, Strominger JL. IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells. J Immunol 2004 173 : 7548 55.
10. Battaglia M, Gregori S, Bacchetta R, Roncarolo MG. Tr1 cells: from discovery to their clinical application. Semin Immunol 2006 18 : 120 7.
11. Stock P, Akbari O, Berry G, Freeman GJ, Dekruyff RH, Umetsu DT. Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat Immunol 2004 5 : 1149 56.
12. Dillon S, Agrawal S, Banerjee K et al. Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest 2006 116 : 916 28.
13. van der Kleij D, Latz E, Brouwers JF et al. A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates Toll-like receptor 2 and affects immune polarization. J Biol Chem 2002 277 : 48122 9.
14. van Riet E, Hartgers FC, Yazdanbakhsh M. Chronic helminth infections induce immunomodulation: consequences and mechanisms. Immunobiology 2007 212 : 475 90.
15. Goldman M. Translational mini-review series on Toll-like receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders. Clin Exp Immunol 2007 147 : 208 16.
16. Chu HW, Jeyaseelan S, Rino JG et al. TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expression. J Immunol 2005 174 : 5713 9.
17. Varadaradjalou S, Feger F, Thieblemont N et al. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells. Eur J Immunol 2003 33 : 899 906.
18. Aliprantis AO, Yang RB, Weiss DS, Godowski P, Zychlinsky A. The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J 2000 19 : 3325 36.