Inhaled non-capsulated Bacillus anthracis in A/J mice: nasopharynx and alveolar space as dual portals of entry, delayed dissemination, and specific organ targeting

Microbes and Infection

Volumn 10, Issue 12-13, 2008, Pages 1398-1404

  Glomski, Ian J ^a,b   Dumetz, Fabien ^a,b   Jouvion, Gregory ^a   Huerre, Michel R ^a   Mock, Michèle ^a,b   Goossens, Pierre L ^a,b  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

Author keywords

Anthrax; Inhalational infection; Kidney; Lung; Mice; Toxin

Indexed keywords

TOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; BIOLUMINESCENCE; FEMALE; LUNG ALVEOLUS; LUNG INFECTION; MOUSE; NASOPHARYNX; NONHUMAN; PRIORITY JOURNAL; SPORE GERMINATION;

ADMINISTRATION, INHALATION; ANIMALS; ANTHRAX; BACILLUS ANTHRACIS; DISEASE MODELS, ANIMAL; FEMALE; KIDNEY; LUNG; MICE; NASOPHARYNX; PULMONARY ALVEOLI; SPORES, BACTERIAL;

BACILLUS ANTHRACIS; MUS;

EID: 54849428911     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2008.07.042     Document Type: Article

References (20)

1. Mock M., and Fouet A. Anthrax, Annu. Rev. Microbiol 55 (2001) 647-671
2. Moayeri M., and Leppla S.H. The roles of anthrax toxin in pathogenesis. Curr. Opin. Microbiol 7 (2004) 19-24
3. Makino S., Uchida I., Terakado N., Sasakawa C., and Yoshikawa M. Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis. J. Bacteriol 171 (1989) 722-730
4. Drysdale M., Heninger S., Hutt J., Chen Y., Lyons C.R., and Koehler T.M. Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax. EMBO J 24 (2005) 221-227
5. Glomski I.J., Piris-Gimenez A., Huerre M., Mock M., and Goossens P.L. Primary involvement of pharynx and Peyer's patch in inhalational and intestinal anthrax. PLoS Pathog 3 (2007) e76
6. Glomski I.J., Corre J.P., Mock M., and Goossens P.L. Noncapsulated toxinogenic Bacillus anthracis presents a specific growth and dissemination pattern in naive and protective antigen-immune mice. Infect. Immun 75 (2007) 4754-4761
7. Sanz P., Teel L.D., Alem F., Carvalho H.M., Darnell S.C., and O'Brien A.D. Detection of Bacillus anthracis spore germination in vivo by bioluminescence imaging. Infect. Immun. (2008)
8. Harvill E.T., Lee G., Grippe V.K., and Merkel T.J. Complement depletion renders C57BL/6 mice sensitive to the Bacillus anthracis Sterne strain. Infect. Immun 73 (2005) 4420-4422
9. Loving C.L., Kennett M., Lee G.M., Grippe V.K., and Merkel T.J. Murine aerosol challenge model of anthrax. Infect. Immun 75 (2007) 2689-2698
10. Francis K.P., Yu J., Bellinger-Kawahara C., Joh D., Hawkinson M.J., Xiao G., Purchio T.F., Caparon M.G., Lipsitch M., and Contag P.R. Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon. Infect. Immun 69 (2001) 3350-3358
11. Sylvestre P., Couture-Tosi E., and Mock M. Contribution of ExsFA and ExsFB proteins to the localization of BclA on the spore surface and to the stability of the Bacillus anthracis exosporium. J. Bacteriol 187 (2005) 5122-5128
12. Berthier M., Fauchere J.L., and Perrin J. Fulminant meningitis due to Bacillus anthracis in 11-year-old girl during Ramadan. Lancet 347 (1996) 828
13. Sylvestre P., Couture-Tosi E., and Mock M. Polymorphism in the collagen-like region of the Bacillus anthracis BclA protein leads to variation in exosporium filament length. J. Bacteriol 185 (2003) 1555-1563
14. E. Prophet, B. Mills, J. Arrington, Methods in Histotechnology, AFIP, Washington, 1992.
15. Guidi-Rontani C., Weber-Levy M., Labruyere E., and Mock M. Germination of Bacillus anthracis spores within alveolar macrophages. Mol. Microbiol 31 (1999) 9-17
16. Cleret A., Quesnel-Hellmann A., Vallon-Eberhard A., Verrier B., Jung S., Vidal D., Mathieu J., and Tournier J.N. Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route. J. Immunol 178 (2007) 7994-8001
17. Gimenez A.P., Wu Y.Z., Paya M., Delclaux C., Touqui L., and Goossens P.L. High bactericidal efficiency of type iia phospholipase A2 against Bacillus anthracis and inhibition of its secretion by the lethal toxin. J. Immunol 173 (2004) 521-530
18. Zaucha G.M., Pitt L.M., Estep J., Ivins B.E., and Friedlander A.M. The pathology of experimental anthrax in rabbits exposed by inhalation and subcutaneous inoculation, Arch. Pathol. Lab. Med 122 (1998) 982-992
19. Warfel J.M., Steele A.D., and D'Agnillo F. Anthrax lethal toxin induces endothelial barrier dysfunction. Am. J. Pathol 166 (2005) 1871-1881
20. Baldari C.T., Tonello F., Paccani S.R., and Montecucco C. Anthrax toxins: a paradigm of bacterial immune suppression. Trends Immunol 27 (2006) 434-440