An Intrinsic Degradation Tag on the ClpA C-Terminus Regulates the Balance of ClpAP Complexes with Different Substrate Specificity

Journal of Molecular Biology

Volumn 384, Issue 2, 2008, Pages 503-511

  Maglica, Željka ^a   Striebel, Frank ^a   Weber Ban, Eilika ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

AAA ATPase; autodegradation; ClpA; ClpAP; protease

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ESCHERICHIA COLI PROTEIN; GREEN FLUORESCENT PROTEIN; PROTEIN CLPA; PROTEIN CLPAP; UNCLASSIFIED DRUG;

ARTICLE; ENZYME SPECIFICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

ESCHERICHIA COLI;

EID: 54849425578     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.09.046     Document Type: Article

References (28)

1. Gottesman S. Proteolysis in bacterial regulatory circuits. Annu. Rev. Cell Dev. Biol. 19 (2003) 565-587
2. Bukau B., Weissman J., and Horwich A. Molecular chaperones and protein quality control. Cell 125 (2006) 443-451
3. Sauer R.T., Bolon D.N., Burton B.M., Burton R.E., Flynn J.M., Grant R.A., et al. Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell 119 (2004) 9-18
4. Wickner S., Maurizi M.R., and Gottesman S. Posttranslational quality control: folding, refolding, and degrading proteins. Science 286 (1999) 1888-1893
5. Katayama-Fujimura Y., Gottesman S., and Maurizi M.R. A multiple-component, ATP-dependent protease from Escherichia coli. J. Biol. Chem. 262 (1987) 4477-4485
6. Gottesman S., Clark W.P., de Crecy-Lagard V., and Maurizi M.R. ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. Sequence and in vivo activities. J. Biol. Chem. 268 (1993) 22618-22626
7. Gottesman S., Roche E., Zhou Y., and Sauer R.T. The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system. Genes Dev. 12 (1998) 1338-1347
8. Flynn J.M., Neher S.B., Kim Y.I., Sauer R.T., and Baker T.A. Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals. Mol. Cell 11 (2003) 671-683
9. Moore S.D., and Sauer R.T. The tmRNA system for translational surveillance and ribosome rescue. Annu. Rev. Biochem. 76 (2007) 101-124
10. Farrell C.M., Grossman A.D., and Sauer R.T. Cytoplasmic degradation of ssrA-tagged proteins. Mol. Microbiol. 57 (2005) 1750-1761
11. Lies M., and Maurizi M.R. Turnover of endogenous SsrA-tagged proteins mediated by ATP-dependent proteases in Escherichia coli. J. Biol. Chem. 283 (2008) 22918-22929
12. Levchenko I., Seidel M., Sauer R.T., and Baker T.A. A specificity-enhancing factor for the ClpXP degradation machine. Science 289 (2000) 2354-2356
13. Flynn J.M., Levchenko I., Seidel M., Wickner S.H., Sauer R.T., and Baker T.A. Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis. Proc. Natl Acad. Sci. USA 98 (2001) 10584-10589
14. Dougan D.A., Reid B.G., Horwich A.L., and Bukau B. ClpS, a substrate modulator of the ClpAP machine. Mol. Cell 9 (2002) 673-683
15. Zeth K., Ravelli R.B., Paal K., Cusack S., Bukau B., and Dougan D.A. Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA. Nat. Struct. Biol. 9 (2002) 906-911
16. Erbse A., Schmidt R., Bornemann T., Schneider-Mergener J., Mogk A., Zahn R., et al. ClpS is an essential component of the N-end rule pathway in Escherichia coli. Nature 439 (2006) 753-756
17. Gottesman S., Clark W.P., and Maurizi M.R. The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate. J. Biol. Chem. 265 (1990) 7886-7893
18. Seol J.H., Yoo S.J., Kang M.S., Ha D.B., and Chung C.H. The 65-kDa protein derived from the internal translational start site of the clpA gene blocks autodegradation of ClpA by the ATP-dependent protease Ti in Escherichia coli. FEBS Lett. 377 (1995) 41-43
19. Cranz-Mileva S., Imkamp F., Kolygo K., Maglica Z., Kress W., and Weber-Ban E. The flexible attachment of the N-domains to the ClpA ring body allows their use on demand. J. Mol. Biol. 378 (2008) 412-424
20. Maurizi M.R., Singh S.K., Thompson M.W., Kessel M., and Ginsburg A. Molecular properties of ClpAP protease of Escherichia coli: ATP-dependent association of ClpA and clpP. Biochemistry 37 (1998) 7778-7786
21. Kress W., Mutschler H., and Weber-Ban E. Assembly pathway of an AAA+ protein: tracking ClpA and ClpAP complex formation in real time. Biochemistry 46 (2007) 6183-6193
22. Hinnerwisch J., Fenton W.A., Furtak K.J., Farr G.W., and Horwich A.L. Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation. Cell 121 (2005) 1029-1041
23. Guo F., Maurizi M.R., Esser L., and Xia D. Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease. J. Biol. Chem. 277 (2002) 46743-46752
24. Weber-Ban E.U., Reid B.G., Miranker A.D., and Horwich A.L. Global unfolding of a substrate protein by the Hsp100 chaperone ClpA. Nature 401 (1999) 90-93
25. Dougan D.A., Mogk A., Zeth K., Turgay K., and Bukau B. AAA+ proteins and substrate recognition, it all depends on their partner in crime. FEBS Lett. 529 (2002) 6-10
26. Hou J.Y., Sauer R.T., and Baker T.A. Distinct structural elements of the adaptor ClpS are required for regulating degradation by ClpAP. Nat. Struct. Mol. Biol. 15 (2008) 288-294
27. Fujihara A., Tomatsu H., Inagaki S., Tadaki T., Ushida C., Himeno H., and Muto A. Detection of tmRNA-mediated trans-translation products in Bacillus subtilis. Genes Cells 7 (2002) 343-350
28. Neuenschwander M., Butz M., Heintz C., Kast P., and Hilvert D. A simple selection strategy for evolving highly efficient enzymes. Nat. Biotechnol. 25 (2007) 1145-1147