The ocular albinism type 1 gene product is an N-glycoprotein but glycosylation is not required for its subcellular distribution

Pigment Cell Research

Volumn 14, Issue 6, 2001, Pages 485-490

  Shen, Bin ^b   Orlow, Seth J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Endo lysosome; Glycoprotein; Melanosome; Tyrosinase

Indexed keywords

MURINAE;

DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; EYE PROTEIN; GREEN FLUORESCENT PROTEIN; LEUKOCYTE ANTIGEN; LYSOSOME ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEIN; OA1 PROTEIN; PHOTOPROTEIN;

ANIMAL; ARTICLE; CELL COMPARTMENTALIZATION; CELL LINE; CELL STRAIN COS1; CYTOLOGY; CYTOPLASM VESICLE; GENETIC TRANSFECTION; GENETICS; GLYCOSYLATION; HUMAN; LYSOSOME; MELANOCYTE; METABOLISM; MOUSE; MUTATION; OCULAR ALBINISM; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN TRANSPORT; RETINA; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ALBINISM, OCULAR; ANIMAL; ANTIGENS, CD; CELL COMPARTMENTATION; CELL LINE, TRANSFORMED; COS CELLS; CYTOPLASMIC VESICLES; EYE PROTEINS; GLYCOSYLATION; HUMAN; INDICATORS AND REAGENTS; LUMINESCENT PROTEINS; LYSOSOMES; MELANOCYTES; MEMBRANE GLYCOPROTEINS; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN TRANSPORT; RETINA; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION;

EID: 0035542882     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0749.2001.140609.x     Document Type: Article

References (21)

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5. Analysis of the OA1 gene reveals mutations in only one-third of patients with X-linked ocular albinism
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12. Tyrosinases from two different loci are expressed by normal and by transformed melanocytes
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15. Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome
16. Molecular basis of albinism: Mutations and polymorphisms of pigmentation genes associated with albinism
17. Diverse prevalence of large deletions within the OA1 gene in ocular albinism type 1 patients from Europe and North America
18. Inhibition of N-glycan processing in B16 melanoma cells results in inactivation of tyrosinase but does not prevent its transport to the melanosome
19. Translation rate of human tyrosinase determines its N-linked glycosylation level
20. Protein specific N-glycosylation of tyrosinase and tyrosinase-related protein-1 in B16 mouse melanoma cells
21. Oligosaccharide trimming plays a role in the endoplasmic reticulum-associated degradation of tyrosinase