The association of ACE gene D/I polymorphism with cardiovascular risk factors in a population from Rio de Janeiro

Brazilian Journal of Medical and Biological Research

Volumn 41, Issue 6, 2008, Pages 512-518

  Cardoso, R L ^a   Nogueira, A R ^a   Salis, L H A ^a   Urmenyi T P ^a   Silva, R ^a   Moura Neto, R S ^a   Pereira, B B ^a   Rondinelli, E ^a   de Souza e Silva, N A ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Albuminuria; Angiotensin converting enzyme activity; Angiotensin converting enzyme gene polymorphism; Hypertension; Left ventricular hypertrophy

Indexed keywords

ALBUMIN; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; DNA; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID;

ADULT; AGED; ALBUMINURIA; ALLELE; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BRAZIL; CARDIOVASCULAR RISK; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DNA EXTRACTION; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HUMAN; HUMAN CELL; HYPERTENSION; KRUSKAL WALLIS TEST; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; POLYMERASE CHAIN REACTION; POPULATION GENETICS; RISK FACTOR; SEX RATIO; SYSTOLIC BLOOD PRESSURE;

ALBUMINURIA; BLOOD GLUCOSE; BODY MASS INDEX; BRAZIL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GENOTYPE; HUMANS; HYPERTENSION; LIPIDS; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 54749133420     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2008000600013     Document Type: Article

References (30)

1. Inagami T. A memorial to Robert Tiegerstedt: the centennial of renin discovery. Hypertension 1998; 32: 953-957.
2. Nagi DK, Foy CA, Mohamed-Ali V, Yudkin JS, Grant PJ, Knowler WC. Angiotensin-1-converting enzyme (ACE) gene polymorphism, plasma ACE levels, and their association with the metabolic syndrome and electrocardiographic coronary artery disease in Pima Indians. Metabolism 1998; 47: 622-626.
3. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990; 322: 1561-1566.
4. Mancia G, Grassi G. Mechanical and humoral triggers of cardiac hypertrophy. Medicographia 2000; 22: 225-230.
5. Danser AH, Schalekamp MA, Bax WA, van den Brink AM, Saxena PR, Riegger GA, et al. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation 1995; 92: 1387-1388.
6. Grimm RH Jr, Svendsen KH, Kasiske B, Keane WF, Wahi MM. Proteinuria is a risk factor for mortality over 10 years of follow-up. MRFIT Research Group. Multiple Risk Factor Intervention Trial. Kidney Int Suppl 1997; 63: S10-S14.
7. Dell'omo G, Penno G, Pucci L, Lucchesi D, Fotino C, Del Prato S, et al. ACE gene insertion/deletion polymorphism modulates capillary permeability in hypertension. Clin Sci 2006; 111: 357-364.
8. Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992; 359: 641-644.
9. Ryan AS, Nicklas BJ, Berman DM, Ferrell RE. The insertion/deletion polymorphism of the ACE gene is related to insulin sensitivity in overweight women. Diabetes Care 2001; 24: 1646-1652.
10. del Ser T, Bornstein B, Barba R, Cemillan C. Relationship of angiotensin converting enzyme genotype with serum triglyceride concentration in stroke patients. Neurosci Lett 2001; 316: 21-24.
11. Klein CH, Silva NA, Nogueira AR, Bloch KV, Campos LH. Arterial hypertension in Ilha do Governador, Rio de Janeiro, Brazil: I. Methodology. Cad Sad́ude Pública 1995; 11: 187-201.
12. Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 1977; 55: 613-618.
13. Hosmer DW, Lemeshow S. Special topics: in the multinomial logistic regression model. Chapter 8, in Applied logistic regression. New York: Ed. John Wiley & Sons, Inc.; 2000.
14. Souza e Silva NA. Estratégias e métodos de pesquisa clínico-epidemiológicas: vantagens e desvantagens na hipertensão arterial. Rev Bras Hipertensão 2002; 9: 59-74.
15. Lessa I, Mendonca GAS, Teixeira MTB. Noncommunicable chronic diseases in Brazil: from risk factors to social impact. Bol Of Sanit Panam 1986; 120: 389-413.
16. Bloch KV, Klein CH, de Souza e Silva NA, Nogueira AR, Salis LH. Socioeconomic aspects of spousal concordance for hypertension, obesity, and smoking in a community of Rio de Janeiro, Brazil. Arq Bras Cardiol 2003; 80: 179-186.
17. Silva KM, Sucharov CC, Rondinelli E, Carvalho ACC, Nogueira AR, Campos LHS, et al. Distribution of angiotensin converting enzyme(ACE) I and D allele frequencies in a sample of 200 subjects of Rio de Janeiro, Brasil. J Am Coll Cardiol 1998; 31 (5 suppl C): 371C.
18. Pereira AC, Mota GA, Bensenor I, Lotufo PA, Krieger JE. Effect of race, genetic population structure, and genetic models in two-locus association studies: clustering of functional renin-angiotensin system gene variants in hypertension association studies. Braz J Med Biol Res 2001; 34: 1421-1428.
19. Staessen JA, Wang JG, Ginocchio G, Petrov V, Saavedra AP, Soubrier F, et al. The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk. J Hypertens 1997; 15: 1579-1592.
20. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998; 97: 1766-1772.
21. Hadjadj S, Belloum R, Bouhanick B, Gallois Y, Guilloteau G, Chatellier G, et al. Prognostic value of angiotensin-I converting enzyme I/D polymorphism for nephropathy in type 1 diabetes mellitus: a prospective study. J Am Soc Nephrol 2001; 12: 541-549.
22. Meerson FZ. The myocardium in hyperfunction, hypertrophy and heart failure. Circ Res 1969; 25 (Suppl 2): 1-163.
23. Estacio RO, Jeffers BW, Havranek EP, Krick D, Raynolds M, Schrier RW. Deletion polymorphism of the angiotensin converting enzyme gene is associated with an increase in left ventricular mass in men with type 2 diabetes mellitus. Am J Hypertens 1999; 12: 637-642.
24. Perticone F, Maio R, Cosco C, Ceravolo R, Iacopino S, Chello M, et al. Hypertensive left ventricular remodeling and ACE-gene polymorphism. Cardiovasc Res 1999; 43: 192-199.
25. Montgomery HE, Clarkson P, Dollery CM, Prasad K, Losi MA, Hemingway H, et al. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation 1997; 96: 741-747.
26. Pontremoli R, Sofia A, Tirotta A, Ravera M, Nicolella C, Viazzi F, et al. The deletion polymorphism of the angiotensin I-converting enzyme gene is associated with target organ damage in essential hypertension. J Am Soc Nephrol 1996; 7: 2550-2558.
27. Redon J, Chaves FJ, Liao Y, Pascual JM, Rovira E, Armengod ME, et al. Influence of the I/D polymorphism of the angiotensin-converting enzyme gene on the outcome of microalbuminuria in essential hypertension. Hypertension 2000; 35: 490-495.
28. Viitanen L, Pihlajamaki J, Halonen P, Lehtonen M, Kareinen A, Lehto S, et al. Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease. Atherosclerosis 2001; 157: 57-64.
29. Huang XH, Rantalaiho V, Wirta O, Pasternack A, Koivula T, Hiltunen T, et al. Relationship of the angiotensin-converting enzyme gene polymorphism to glucose intolerance, insulin resistance, and hypertension in NIDDM. Hum Genet 1998; 102: 372-378.
30. Barley J, Blackwood A, Carter ND, Crews DE, Cruickshank JK, Jeffery S, et al. Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin. J Hypertens 1994; 12: 955-957.