Investigation of the role of the dopamine transporter in susceptibility to behavioural and psychological symptoms of patients with probable Alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 26, Issue 3, 2008, Pages 257-260

  Pritchard, Antonia L ^a,b   Pritchard, Colin W ^c   Bentham, Peter ^b   Lendon, Corinne L ^a,b  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c ROYAL CORNWALL HOSPITAL   (United Kingdom)

Author keywords

Aggression; Alzheimer's disease; Depression; Dopamine; Dopamine transporter 1; Elation mania; Psychosis

Indexed keywords

DOPAMINE TRANSPORTER;

3' UNTRANSLATED REGION; AGED; AGGRESSION; AGITATION; ALZHEIMER DISEASE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DELUSION; DISEASE COURSE; DOPAMINE TRANSPORTER 1 GENE; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HALLUCINATION; HUMAN; IRRITABILITY; LOCOMOTION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PRIORITY JOURNAL; RISK FACTOR; VARIABLE NUMBER OF TANDEM REPEAT;

3' UNTRANSLATED REGIONS; AGED; AGED, 80 AND OVER; AGGRESSION; ALZHEIMER DISEASE; COHORT STUDIES; DEPRESSION; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IRRITABLE MOOD; LONGITUDINAL STUDIES; MALE; MENTAL DISORDERS; PHENOTYPE; RISK FACTORS; TANDEM REPEAT SEQUENCES;

EID: 54749129560     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000160958     Document Type: Article

References (10)

1. Lyketsos CG, Tune L, Pearlson G, Steele C: Major depression in Alzheimer's disease: an interaction between gender and family history. Psychosomatics 1996;37:380-384.
2. Sweet RA, Nimganokar V, Devlin B, Lopez O, De Kosky S: Increased familial risk of the psychotic phenotype of Alzheimer's disease. Neurology 2002;58:907-911.
3. Tunstall N, Owen M, Williams J, Rice F, Carty S, Lillystone S, Fraser L, Kehoe P, Neill D, Rudrasingham V, Sham P, Lovestone S: Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease. Br J Psychiatry 2000;176:156-159.
4. Sweet RA, Nimganokar V, Kamboh I, Lopez O, Zhang F, De Kosky S: Dopamine receptor genetic variation, psychosis, and aggression in Alzheimer's disease. Arch Neurol 1998;55:1335-1340.
5. Holmes C, Smith H, Ganderton R, Arranz M, Collier D, Powell J, Lovestone S: Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation. J Neurol Neurosurg Psychiatry 2001;71:777-779.
6. NIH: Genetic association database. http:// geneticassociationdb.nih.gov/.
7. Courtney C, Farrell D, Gray R, Hills R, Lynch L, Sellwood E, Edwards S, Hardyman W, Raftery J, Crome P, Lendon C, Shaw H, Bentham P, Group AC: Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet 2004;363:2105-2115.
8. Cummings JL, Mega M, Gray K: The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308-2314.
9. Michelhaugh SK, Fiskerstrand C, Lovejoy E, Bannon MJ, Quinn J: The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurones. J Neurochem 2001;79:1033-1038.
10. Cooper JK, Mungas D, Weiler PG: Relation of cognitive status and abnormal behaviors in Alzheimer's disease. J Am Geriatr Soc 1990;38:867-870.