Nasal administration of Lactococcus lactis improves local and systemic immune responses against Streptococcus pneumoniae

Microbiology and Immunology

Volumn 52, Issue 8, 2008, Pages 399-409

  Medina, Marcela ^a,b   Villena, Julio ^a,b   Salva, Susana ^a   Vintiñi, Elisa ^b   Langella, Philippe ^c   Alvarez, Susana ^a,b  

^a UNIVERSIDAD NACIONAL DE TUCUMÁN   (Argentina)

^b CENTRO DE REFERENCIA PARA LACTOBACILOS CERELA CONICET   (Argentina)

^c CEMAGREF   (France)

Author keywords

Adjuvant; Lactococcus lactis; Nasal administration; Pneumococcal infection

Indexed keywords

ALBUMIN; BACTERIAL PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOSTIMULATING AGENT; LACTATE DEHYDROGENASE; PEROXIDASE; IMMUNOLOGICAL ADJUVANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; BONE MARROW; CLEARANCE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOSTIMULATION; INNATE IMMUNITY; LACTOCOCCUS LACTIS; LUNG; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PHAGOCYTE; PNEUMOCOCCAL INFECTION; STREPTOCOCCUS PNEUMONIAE; TISSUE INJURY; UPREGULATION; ANIMAL; HUMAN; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; STREPTOCOCCUS INFECTION; TREATMENT OUTCOME;

BACTERIA (MICROORGANISMS); LACTOCOCCUS LACTIS; STREPTOCOCCUS PNEUMONIAE;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LACTOCOCCUS LACTIS; LUNG; MALE; MICE; PHAGOCYTES; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; TREATMENT OUTCOME;

EID: 54749097525     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2008.00050.x     Document Type: Article

References (36)

1. Ruvinsky R., Gentile A., Regueira M., Corso A. (2002) Infecciones invasivas por Streptococcus pneumoniae: estudio epidemiológico e importancia del desarrollo de un sistema de vigilancia. Arch Argent Pediatr 100: 31-5 (in Spanish).
2. Foxwell R., Kyd J.M., Cripps A.W. (2003) Mucosal immunization against respiratory bacterial pathogens. Expert Rev Vaccines 2: 551-60.
3. Holllingshed S.K., Briles D.E. (2001) Streptococcus pneumoniae: new tools for an old pathogen. Curr Opin Microbiol 4: 71-7.
4. Hirose J., Kouro T., Igarashi H., Yokota T., Sakaguchi N., Kincade P.W. (2002) A developing picture of lymphopoiesis in bone marrow. Immun Rev 189: 28-40.
5. Corthier G., Renault P. (1999) Future directions for research on biotherapeutic agents: contributions of genetic approaches on lactic acid bacteria. In: Elmer G.W., ed. Biotherapeutic agents and infectious diseases. Totowa, NJ: Humana Press Inc., pp. 269-304.
6. Miyoshi A., Poquet I., Azevedo V., Commissaire J., Bermudez-Humaran L., Domakova E. et al. (2002) Controlled production of stable heterologous proteins in Lactococcus lactis. Appl Environ Microbiol 68: 3141-6.
7. Bermúdez-Humarán L.G., Langella P., Cortes-Perez N.G., Gruss A., Tamez-Guerra R.S., Oliveira S.C. et al. (2003) Intranasal immunization with recombinant Lactococcus lactis secreting murine interleukin-12 enhances antigen-specific Th1 cytokine production. Infect Immun 71: 1887-96.
8. Enouf V., Langella P., Commissaire J., Cohen J., Corthier G. (2001) Bovine rotavirus nonstructural protein 4 produced by Lactococcus lactis is antigenic and immunogenic. Appl Environ Microbiol 67: 1423-8.
9. Mercenier A., Muller-Alouf H., Grangette C. (2000) Lactic acid bacteria as live vaccines. Curr Issues Mol Biol 2: 17-25.
10. Nouaille S., Ribeiro L.A., Miyoshi A., Pontes D., Le Loir Y., Oliveira S.C. et al. V. (2003) Heterologous protein production and delivery systems for Lactococcus lactis. Genet Mol Res 2: 102-11.
11. BoersmaW.J.A., Shaw M., Claassen E. (2000) Probiotic bacteria as live oral vaccines: Lactobacillus as the versatile delivery vehicle. In: Fuller R., Perdigón G., eds, Probiotics 3: Immunomodulation by the Gut Microflora and Probiotics, 1st edn. London: Kluwer Academic Publishers, pp. 234-70.
12. Alvarez S., Herrero C., Bru E., Perdigón G. (2001) Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice. J Food Protect 64: 1768-74.
13. Villena J., Racedo S., Agüero G., Bru E., Medina M., Alvarez S. (2005) Lactobacillus casei improves resistance to pneumococcal respiratory infection in malnourished mice. J Nutr 135: 1462-9.
14. Villena J., Racedo S., Agüero G., Alvarez S. (2006) Yogurt accelerates the recovery of defence mechanisms against Streptococcus pneumoniae in protein malnourished mice. Br J Nutr 95: 591-602.
15. Kiyono H., Fukuyama S. (2004) NALT-versus Peyer's patch mediated mucosal immunity. Nat Rev Immunol 4: 699-710.
16. Facklam R.,Washington II J.A. (1992) Streptococcus and related catalase negative gram positive cocci. In: Balows A., HauslerW.J. Jr., Kenneth L.H., Isenberg H.D., Shadomy J., eds. Manual of Clinical Microbiology, 5th edn.Washington, DC: American Society for Microbiology, pp. 238-57.
17. Silverman E.M., Ryde S.E. (1974) The nitroblue tetrazolium (NBT) test: A simple, reliable method and a review of its significance. Am J Med Technol 40: 151-7.
18. Ueda Y., Kondo M., Kelsoe G. (2005) Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J ExpMed 201: 1771-80.
19. Hussell T., Humphreys I.R. (2002) Nasal vaccination induces protective immunity without immunopathology. Clin Exp Immunol 130: 359-62.
20. Fowler N.G. (1992) Antimicrobials and competitive exclusion. Int J Food Microbiol 15: 277-9.
21. Standiford T.J., Kunkel S.L., Greenberger M.J., Laichalk L.L., Strieter R.M. (1996) Expression and regulation of chemokines in bacterial pneumonia. J Leukoc Biol 59: 24-8.
22. Nelson S., Summer W.R. (1998) Innate immunity, cytokines and pulmonary host defense. Infect Dis Clin North Am 12: 555-67.
23. Furfaro S., Berman J.S., Center D.M. (1996) Determinants of T cell migration in the lung. In: Kradin R.L., Robinson B.W.S., eds. Immunopathology of Lung Disease., Boston,NJ: Butterworth-Heinemann, pp. 15-32.
24. Perdigón G., Alvarez S., Medina M., Vintiñi E., Roux E. (1999) Influence of the oral administration of lactic acid bacteria on IgA producing cells associated to bronchus. Int J Immunopathol Pharmacol 12: 97-102.
25. Mazanec M.B., Kaetzel C.S., Lamm M.E., Fletcher D., Nedruf J.G. (1992) Intracellular neutralization of virus by immunoglobulin A antibodies. Proc Natl Acad Sci USA 89: 6901-5.
26. Brandtzaeg P. (1992) Humoral immune response patterns of human mucosae: induction and relation to bacterial respiratory tract infections. J Infect Dis 165: 167-76.
27. Janoff E.N., Fasching C., Oresnstein J.M., Rubins J.B., Osptad N. L., Dalmasso A.P. (1999) Killing of Streptococcus pneumoniae by capsular polysaccharide-specific polymeric IgA, complement, and phagocytes. J Clin Invest 104: 1139-47.
28. García V.E., Gherardi M.M., Iglesias M.F., Cerquetti M.C., Sordelli D.O. (1993) Local and systemic immunity against Streptococcus pneumoniae: Humoral responses against a non-capsulated temperature-sensitive mutant. FEMS Microbiol Lett 108: 163-7.
29. Blum S., Delneste Y., Alvarez S., Haller D., Pérez P., Bode C.H. et al. (1999) Interactions between commensal bacteria and mucosal immunocompetent cells. Internat Dairy J 9: 63-9.
30. Miettinen M., Vuopio-Varkila J., Varkila K. (1996) Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria. Infect Immun 64: 5403-5.
31. Antilla M., Voutilainen M., Jantti V., Eskola J., Kayhty H. (1999) Contribution of serotype-specific IgG concentration, IgG subclasses and relative antibody avidity to opsonophagocytic activity against Streptococcus pneumoniae. Clin Exp Immunol 118: 402-7.
32. Jones H.P., Hodge L.M., Fujihashi K., Kiyono H., McGhee J.R., Simecka J.W. (2001) The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. J Immunol 167: 4518-26.
33. Monteiro J.P., Benjamin A., Costa E.S., Barcinski M.A., Bonomo A. (2005) Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells. Blood 105: 1484-91.
34. Ogunniyi D., Folland R.L., Briles D.E., Hollingshead S.K., Paton J.C. (2000) Immunization of mice with combinations of pneumococcal virulence proteins elicits enhances protection against challenge with Streptococcus pneumoniae. Infect Immun 68: 3028-32.
35. Kim J.O.,Weiser J.N. (1998) Association of intrastrain phase variation in quantity of capsular polysaccharide and teichoic acid with the virulence of Streptococcus pneumoniae. J Infect Dis 177: 368-77.
36. Weiser J.N., Austrian R., Sreenivasan P.K., Masure H.R. (1994) Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization. Infect Immun 62: 2582-7.