Key amino acids in the aryl hydrocarbon receptor predict dioxin sensitivity in avian species

Environmental Science and Technology

Volumn 42, Issue 19, 2008, Pages 7535-7541

  Head, Jessica A ^a,b   Hahn, Mark E ^c   Kennedy, Sean W ^a,b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b ENVIRONMENT CANADA   (Canada)

^c WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINES; BIOCHEMISTRY; HYDROCARBONS; OCCUPATIONAL RISKS; ORGANIC ACIDS; ORGANIC COMPOUNDS; RISK ASSESSMENT; RISK MANAGEMENT; AMINO ACIDS; ANIMALS; ORGANIC POLLUTANTS;

AMINO ACID RESIDUES; ARYL HYDROCARBON RECEPTOR; AVIAN SPECIES; BIOCHEMICAL RESPONSES; DIOXIN-LIKE COMPOUNDS; JAPANESE QUAIL; LIGAND-BINDING DOMAIN; TETRACHLORODIBENZO-P-DIOXIN; TOXICITY DATA; WILD BIRDS;

AMINO ACIDS; SENSITIVITY ANALYSIS;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALANINE; AMINO ACID; AROMATIC HYDROCARBON RECEPTOR; DIOXIN; ISOLEUCINE; VALINE;

AMINO ACID; DIOXIN; EMBRYO; GAMEBIRD; HYDROCARBON; PASSERINE; RISK ASSESSMENT; SEABIRD; TOXICITY; WATERFOWL; WILD POPULATION;

ARTICLE; BIRD; CHICKEN; EMBRYOTOXICITY; GENE SEQUENCE; GENOTYPE; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; RISK ASSESSMENT; SPECIES DIFFERENCE; TURKEY (BIRD); WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; BIRDS; DIOXINS; GENOTYPE; MOLECULAR SEQUENCE DATA; OVUM; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ARYL HYDROCARBON; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

ANAS; AVES; COTURNIX JAPONICA; FALCO SPARVERIUS; GALLUS GALLUS; LARUS ARGENTATUS; PHALACROCORAX AURITUS; PHASIANIDAE; SIALIA SIALIS; STERNA HIRUNDO; VERTEBRATA;

2 ,3 ,7 ,8 TETRACHLORODIBENZO P DIOXINS; AMINO ACID RESIDUES; ARYL HYDROCARBON RECEPTOR; AVIAN SPECIES; BIOCHEMICAL RESPONSE; DIOXIN-LIKE COMPOUNDS; GENETIC SCREENS; JAPANESE QUAIL; LIGAND BINDING DOMAIN; TOXICITY DATA; WILD BIRDS;

EID: 54749095177     PISSN: 0013936X     EISSN: None     Source Type: Journal    
DOI: 10.1021/es801082a     Document Type: Article

References (41)

1. Okey, A. B. An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI. Toxicol. Sci. 2007, 98, 5-38.
2. Pohjanvirta, R.; Tuomisto, J. Short-term toxicity of 2,3,7,8- tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models. Pharmacol. Rev. 1994, 46, 483-549.
3. Gilbertson, M.; Kubiak, T.; Ludwig, J.; Fox, G. Great Lakes embryo mortality, edema, and deformities syndrome (GLEMEDS) in colonial fish-eating birds: similarity to chick-edema disease. J. Toxicol. Environ. Health 1991, 33, 455-520.
4. Barron, M. G.; Galbraith, H.; Beltman, D. Comparative reproductive and developmental toxicology of PCBs in birds. Comp. Biochem. Physiol., Part C: Pharmacol., Toxicol. 1995, 112, 1-14.
5. Brunström, B.; Halldin, K. EROD induction by environmental contaminants in avian embryo livers. Comp. Biochem. Physiol., Part C: Pharmacol., Toxicol. 1998, 121, 213-219.
6. Brunström, B.; Andersson, L. Toxicity and 7-ethoxyresorufin O-deethylase-inducing potency of coplanar polychlorinated biphenyls (PCBs) in chick embryos. Arch. Toxicol. 1988, 62, 263-266.
7. Brunström, B. Mono-ortho-chlorinated chlorobiphenyls: toxicity and induction of 7-ethoxyresorufin O-deethylase (EROD) activity in chick embryos. Arch. Toxicol. 1990, 64, 188-192.
8. Hoffman, D. J.; Rice, C. P.; Kubiak, T. J. PCBs and Dioxins in Birds. In Environmental contaminants in wildlife - interpreting tissue concentrations; Beyer, W. N.;,Heinz, G. H., Redmon-Norwood, A. W., Eds.; CRC Press: Boca Raton, FL, 1996; pp 165-207.
9. Brunström, B. Sensitivity of embryos from duck, goose, herring gull, and various chicken breeds to 3,3′,4,4′-tetrachlorobiphenyl. Poult. Sci. 1988, 63, 52-57.
10. Jermyn-Gee, K.; Pekarik, C.; Havelka, T.; Barrett, G.; Weseloh, D. V. An atlas of contaminants in eggs of fish-eating colonial birds of the Great Lakes (1998-2001). Volume I. Accounts by Location; Technical report series 417; Canadian Wildlife Service: Ontario region, 2005.
11. Van den Berg, M.; Birnbaum, L.; Bosveld, A. T. C.; Brunström, B.; Cook, P.; Feeley, M.; Giesy, J. P.; Hanberg, A.; Hasegawa, R.; Kennedy, S. W.; Kubiak, T.; Larsen, J. C.; van Leeuwen, F. X.; Liem, A. K.; Nolt, C.; Peterson, R. E.; Poellinger, L.; Safe, S.; Schrenk, D.; Tillitt, D.; Tysklind, M.; Younes, M.; Waern, F.; Zacharewski, T. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ. Health Perspect. 1998, 106, 775-792.
12. Okey, A. B.; Franc, M. A.; Moffat, I. D.; Tijet, N.; Boutros, P. C.; Korkalainen, M.; Tuomisto, J.; Pohjanvirta, R. Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case of the aryl hydrocarbon receptor. Toxicol. Appl. Pharmacol. 2005, 207, 43-51.
13. Yasui, T.; Kim, E. Y.; Iwata, H.; Tanabe, S. Identification of aryl hydrocarbon receptor 2 in aquatic birds; cDNA cloning of AHR1 and AHR2 and characteristics of their amino acid sequences. Mar. Environ. Res. 2004, 58, 113-118.
14. Hahn, M. E.; Karchner, S. I.; Evans, B. R.; Franks, D. G.; Merson, R. R.; Lapseritis, J. M. Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomics. J. Exp. Zool. Part A Comp. Exp. Biol. 2006, 305, 693-706.
15. Yasui, T.; Kim, E. Y.; Iwata, H.; Franks, D. G.; Karchner, S. I.; Hahn, M. E.; Tanabe, S. Functional characterization and evolutionary history of two aryl hydrocarbon receptor isoforms (AhR1 and AhR2) from avian species. Toxicol. Sci. 2007, 99, 101-117.
16. Karchner, S. I.; Franks, D. G.; Kennedy, S. W.; Hahn, M. E. The molecular basis for differential dioxin sensitivity in birds: Role of the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 6252-6257.
17. Hoffman, D. J.; Melancon, M. J.; Klein, P. N.; Eisemann, J. D.; Spann, J. W. Comparative developmental toxicity of planar polychlorinated biphenyl congeners in chickens, American kestrels, and common terns. Environ. Toxicol. Chem. 1998, 17, 747-757.
18. Augspurger, T. P. The wood duck (Aix sponsa) as a sentinel of exposure to and effects of polychlorinated dibenzo-p-dioxins and dibenzofurans at contaminated sites, Ph.D. Dissertation, Duke University, Durham, North Carolina, U.S.A., 2006.
19. Powell, D. C.; Aulerich, R. J.; Meadows, J. C.; Tillitt, D. E.; Giesy, J. P.; Stromborg, K. L.; Bursian, S. J. Effects of 3,3′,4,4′,5- pentachlorobiphenyl (PCB 126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) injected into the yolks of chicken (Gallus domesticus) eggs prior to incubation. Arch. Environ. Contam. Toxicol. 1996, 31, 404-409.
20. Henshel, D.; Hehn, B.; Wagey, R.; Vo, M.; Steeves, J. D. The relative sensitivity of chicken embryos to yolk- or air-cell-injected 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ. Toxicol. Chem. 1997, 16, 725-732.
21. Allred, P. M.; Strange, J. R. The effects of 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin on developing chicken embryos. Arch. Environ. Contam. Toxicol. 1977, 6, 483-489.
22. Verrett, M. J. Investigation of the toxic and teratogenic effects of halogenated dipbenzo-p-dioxins and dibenzofurans in the developing chicken embryo;Memo Report; U.S. Food and Drug Administration: Washington, DC, 1976.
23. Powell, D. C.; Aulerich, R. J.; Stromborg, K. L.; Bursian, S. J. Effects of 3,3′,4,4′-tetrachlorobiphenyl, 2,3,3′,4,4′- pentachlorobiphenyl, and 3,3′,4,4′,5-pentachlorobiphenyl on the developing chicken embryo when injected prior to incubation. J. Toxicol. Environ. Health 1996, 49, 319-338.
24. Jin, X.; Kennedy, S. W.; Di Muccio, T.; Moon, T. W. Role of oxidative stress and antioxidant defense in 3,3′,4,4′,5- pentachlorobiphenyl- induced toxicity and species-differential sensitivity in chicken and duck embryos. Toxicol. Appl. Pharmacol. 2001, 172, 241-248.
25. Fox, L. L.; Grasman, K. A. Effects of PCB 126 on primary immune organ development in chicken embryos. J. Toxicol. Environ. Health, Part A 1999, 58, 233-244.
26. Head, J. A.; O'Brien, J.; Kennedy, S. W. Exposure to 3,3′,4, 4′,5-pentachlorobiphenyl during embryonic development has a minimal effect on the cytochrome P4501A response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured chicken embryo hepatocytes. Environ. Toxicol. Chem. 2006, 25, 2981-2989.
27. Head, J. A. Variation in the cytochrome P4501A response to dioxin-like compounds inavianspecies, Ph.D. Dissertation, University of Ottawa, Ottawa, Ontario, Canada, 2006.
28. Kennedy, S. W.; Lorenzen, A.; Jones, S. P.; Hahn, M. E.; Stegeman, J. J. Cytochrome P4501A induction in avian hepatocyte cultures: a promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons. Toxicol. Appl. Pharmacol. 1996, 141, 214-230.
29. Bosveld, A. T. C.; Van den Berg, M. Effects of polychlorinated biphenyls, dibenzo-p-dioxins, and dibenzofurans on fish-eating birds. Environ. Rev. 1994, 2, 147-166.
30. Brunström, B.; Reutergardh, L. Differences in sensitivity of some avian species to the embryotoxicity of a PCB, 3,3′,4,4′- tetrachlorobiphenyl, injected into the eggs. Environ. Pollut. 1986, 42, 37-45.
31. Sanderson, J. T.; Bellward, G. D. Hepatic microsomal ethoxyresorufin O-deethylase-inducing potency in ovo and cytosolic Ah receptor binding affinity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: comparison of four avian species. Toxicol. Appl. Pharmacol. 1995, 132, 131-145.
32. Lorenzen, A.; Shutt, J. L.; Kennedy, S. W. Sensitivity of common tern (Sterna hirundo) embryo hepatocyte cultures to CYP1A induction and porphyrin accumulation by halogenated aromatic hydrocarbons and common tern egg extracts. Arch. Environ. Contam. Toxicol. 1997, 32, 126-134.
33. Poland, A.; Palen, D.; Glover, E. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol. Pharmacol. 1994, 46, 915-921.
34. Goryo, K.; Suzuki, A.; Del Carpio, C. A.; Siizaki, K.; Kuriyama, E.; Mikami, Y.; Kinoshita, K.; Yasumoto, K.; Rannug, A.; Miyamoto, A.; Fujii-Kuriyama, Y.; Sogawa, K. Identification of amino acid residues in the Ah receptor involved in ligand binding. Biochem. Biophys. Res. Commun. 2007, 354, 396-402.
35. Pandini, A.; Denison, M. S.; Song, Y.; Soshilov, A. A.; Bonati, L. Structural and functional characterization of the aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis. Biochemistry 2007, 46, 696-708.
36. Brunstrom, B.; Lund, J. Differences between chick and turkey embryos in sensitivity to 3,3′,4,4′-tetrachlorobiphenyl and in concentration/affinity of the hepatic receptor for 2,3,7,8- tetrachlorodibenzo-p-dioxin. Comp. Biochem. Physiol., Part C: Pharmacol., Toxicol. 1988, 91C, 507-512.
37. Murk, A.; Morse, D.; Boon, J.; Brouwer, A. In vitro metabolism of 3,3′,4,4′-tetrachlorobiphenyl in relation to ethoxyresorufin-O- deethylase activity in liver microsomes of some wildlife species and rat. Eur. J. Pharmacol. 1994, 270, 253-261.
38. Nosek, J. A.; Sullivan, J. R.; Craven, S. R.; Gendron-Fitzpatrick, A.; Peterson, R. E. Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the ring-necked pheasant. Environ. Toxicol. Chem. 1993, 12, 1215-1222.
39. Thiel, D. A.; Martin, S. G.; Duncan, J. W.; Lemke, M. J.; Lance, W. R.; Peterson, R. E. Evaluation of the effects of dioxin-contaminated sludges on wild birds. In Proceedings 1988 Technical Association of Pulp and Paper Environmental Conference; Charleston, SC, U.S.A., April 18-20, 1988; pp 145-148.
40. Brunström, B. Toxicity of coplanar polychlorinated biphenyls in avian embryos. Chemosphere 1989, 19, 765-768.
41. Powell, D. C.; Aulerich, R. J.; Meadows, J. C.; Tillitt, D.; Kelly, M. E.; Stromborg, K. L.; Melancon, M. J.; Fitzgerald, S. D.; Bursian, S. J. Effects of 3,3′,4,4′,5-pentachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo- p-dioxin injected into the yolks of double-crested cormorant (Phalacrocorax auritus) eggs prior to incubation. Environ. Toxicol. Chem. 1998, 17, 2035-2040.