Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation

Hypertension

Volumn 52, Issue 4, 2008, Pages 702-707

  Da Costa Goncalves, Andrey C ^a   Tank, Jens ^b   Plehm, Ralph ^a   Diedrich, Andre ^c   Todiras, Mihail ^a   Gollasch, Maik ^d   Heuser, Arnd ^a   Wellner, Maren ^a   Bader, Michael ^a   Jordan, Jens ^b   Luft, Friedrich C ^a,d   Gross, Volkmar ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Autonomic nervous system; Blood pressure regulation; Spectral analysis; Spinophilin deficient mice; Telemetry

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANGIOTENSIN II; ATROPINE; DOBUTAMINE; METOPROLOL; PHENYLEPHRINE; PRAZOSIN; SPINOPHILIN; TRIMETAPHAN; ACTIN BINDING PROTEIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; NERVE PROTEIN; NEURABIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FOURIER TRANSFORMATION; HEART FUNCTION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TELEMETRY; WILD TYPE; ANIMAL; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; C57BL MOUSE; DRUG EFFECT; ECHOGRAPHY; HEART VENTRICLE; INNERVATION; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; STRESS ECHOCARDIOGRAPHY; VASOCONSTRICTION;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; AUTONOMIC NERVOUS SYSTEM; BAROREFLEX; BLOOD PRESSURE; ECHOCARDIOGRAPHY, STRESS; HEART RATE; HEART VENTRICLES; MALE; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; NERVE TISSUE PROTEINS; PHENYLEPHRINE; PRAZOSIN; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

EID: 54749084335     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.108.114355     Document Type: Article

References (34)

1. Hepler JR. Emerging roles for RGS proteins in cell signalling. Trends Pharmacol Sci. 1999;20:376-382.
2. Zhong H, Neubig RR. Regulator of G protein signaling proteins: novel multifunctional drug targets. J Pharmacol Exp Ther. 2001;297:837-845.
3. Gross V, Tank J, Obst M, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC. Autonomic nervous system and blood pressure regulation in RGS2-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1134-R1142.
4. Hercule HC, Tank J, Plehm R, Wellner M, Costa Goncalves AC, Gollasch M, Diedrich A, Jordan J, Luft FC, Gross V. Cardiovascular control: regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice. Exp Physiol. 2007;92:1014-1022.
5. Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest. 2003;111:445-452.
6. Obst M, Tank J, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC, Gross V. NO-dependent blood pressure regulation in RGS2-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2005;290:R1012-R1019.
7. Tang M, Wang G, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med. 2003;9:1506-1512.
8. Wang Q, Limbird LE. Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3. J Biol Chem. 2002;277:50589-50596.
9. Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science. 2004;304:1940-1944.
10. Wang X, Zeng W, Soyombo AA, Tang W, Ross EM, Barnes AP, Milgram SL, Penninger JM, Allen PB, Greengard P, Muallem S. Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol. 2005;7:405-411.
11. Feng J, Yan Z, Ferreira A, Tomizawa K, Liauw JA, Zhuo M, Allen PB, Ouimet CC, Greengard P. Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci U S A. 2000;97:9287-9292.
12. Li YF, Mayhan WG, Patel KP. NMDA-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide. Am J Physiol Heart Circ Physiol. 2001;281:H2328-H2336.
13. Stec DE, Drummond HA, Vera T. Role of carbon monoxide in blood pressure regulation. Hypertension. 2008;51:597-604.
14. Talman WT, Perrone MH, Reis DJ. Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Science. 1980;209:813-815.
15. Brady AE, Wang Q, Colbran RJ, Allen PB, Greengard P, Limbird LE. Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors. J Biol Chem. 2003;278:32405-32412.
16. Richman JG, Brady AE, Wang Q, Hensel JL, Colbran RJ, Limbird LE. Agonist-regulated interaction between alpha2-adrenergic receptors and spinophilin. J Biol Chem. 2001;276:15003-15008.
17. Smith FD, Oxford GS, Milgram SL. Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. J Biol Chem. 1999;274:19894-19900.
18. Wang X, Zeng W, Kim MS, Allen PB, Greengard P, Muallem S. Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors. EMBO J. 2007;26:2768-2776.
19. Samson WK, Bagley SL, Ferguson AV, White MM. Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress. Am J Physiol Regul Integr Comp Physiol. 2007;292:R382-R387.
20. Uechi M, Asai K, Osaka M, Smith A, Sato N, Wagner TE, Ishikawa Y, Hayakawa H, Vatner DE, Shannon RP, Homcy CJ, Vatner SF. Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac Gsalpha. Circ Res. 1998;82:416-423.
21. Bezerra SM, dos Santos CM, Moreira ED, Krieger EM, Michelini LC. Chronic AT(1) receptor blockade alters autonomic balance and sympathetic responses in hypertension. Hypertension. 2001;38:569-575.
22. Krieger EM. Arterial baroreceptor resetting in hypertension (the J. W. McCubbin memorial lecture). Clin Exp Pharmacol Physiol Suppl. 1989;15:3-17.
23. Laude D, Baudrie V, Elghozi JL. Effects of atropine on the time and frequency domain estimates of blood pressure and heart rate variability in mice. Clin Exp Pharmacol Physiol. 2008;35:454-457.
24. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, Gross V. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension. 2004;43:1042-1047.
25. Janssen BJ, Smits JF. Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification. Am J Physiol Regul Integr Comp Physiol. 2002;282:R1545-R1564.
26. Peotta VA, Gava AL, Vasquez EC, Meyrelles SS. Evaluation of baroreflex control of heart rate in renovascular hypertensive mice. Can J Physiol Pharmacol. 2007;85:761-766.
27. Saleh TM, Connell BJ. The parabrachial nucleus mediates the decreased cardiac baroreflex sensitivity observed following short-term visceral afferent activation. Neuroscience. 1998;87:135-146.
28. Schwartz PJ, La Rovere MT, Vanoli E. Autonomic nervous system and sudden cardiac death. Experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation. 1992;85:177-191.
29. Parati G, Di Rienzo M, Castiglioni P, Bouhaddi M, Cerutti C, Cividjian A, Elghozi JL, Fortrat JO, Girard A, Janssen BJ, Julien C, Karemaker JM, Iellamo F, Laude D, Lukoshkova E, Pagani M, Persson PB, Quintin L, Regnard J, Ruediger JH, Saul PJ, Vettorello M, Wesseling KH, Mancia G. Assessing the sensitivity of spontaneous baroreflex control of the heart: deeper insight into complex physiology. Hypertension. 2004;43:e32-e34.
30. Parlow J, Viale JP, Annat G, Hughson R, Quintin L. Spontaneous cardiac baroreflex in humans. Comparison with drug-induced responses. Hypertension. 1995;25:1058-1068.
31. Li Y, Hashim S, Anand-Srivastava MB. Angiotensin II-evoked enhanced expression of RGS2 attenuates Gi-mediated adenylyl cyclase signaling in A10 cells. Cardiovasc Res. 2005;66:503-511.
32. Liu W, Yuen EY, Allen PB, Feng J, Greengard P, Yan Z. Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. Proc Natl Acad Sci U S A. 2006;103:18338-18343.
33. Allen PB, Ouimet CC, Greengard P. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Proc Natl Acad Sci U S A. 1997;94:9956-9961.
34. Kelker MS, Dancheck B, Ju T, Kessler RP, Hudak J, Nairn AC, Peti W. Structural basis for spinophilin-neurabin receptor interaction. Biochemistry. 2007;46:2333-2344.