Incidence of respiratory metaplasia of the nasal gland epithelium in untreated F344 rats and BDF1 mice subjected to two-year carcinogenicity studies

Journal of Toxicologic Pathology

Volumn 11, Issue 3, 1998, Pages 209-212

  Takeuchi, Tetsuya ^a   Nagano, Kasuke ^a   Katagiri, Taku ^a   Aiso, Shigetoshi ^a   Okudaira, Masahiko ^a   Fujiwara, Kosaku ^b  

^a Japan Bioassay Research Center   (Japan)

^b NIHON UNIVERSITY   (Japan)

Author keywords

BDF1 mouse; Bowman's gland; F344 rat; Nasal gland; Nasal mucosa; Respiratory metaplasia

Indexed keywords

EID: 54649083010     PISSN: 09149198     EISSN: 09149198     Source Type: Journal    
DOI: 10.1293/tox.11.209     Document Type: Article

References (23)

1. Nagano K, Enomoto M, Yamanouchi K, Aiso S, Katagiri T, and Matumoto M. Toxicologic pathology of upper respiratory tract (in Japanese). J Toxicol Pathol 1988; 1: 115-27.
2. Nagano K, Katagiri T, Aiso S, Senoh H, Sakura Y, and Takeuchi T. Spontaneous lesions of nasal cavity in aging F344 rats and BDF1 mice. Exp Toxic Pathol 1997; 49: 97-104
3. Takeuchi T, Nagano K, Aiso S, Katagiri T, Okudaira M, and Fujiwara K. Occurrence of foreign body rhinitis in F344 rats during toxicologic studies. J Toxicol Pathol 1997; 10: 25-9.
4. Monticelo TM, Morgan KT, and Uraih L. Nonneoplastic nasal lesions in rats and mice. Environ Health Perspect 1990; 85: 249-74.
5. Gaskell BA. Nonneoplastic changes in the olfactory epithelium: experimental studies. Environ Health Perspect 1990; 85: 275-89.
6. Woutersen RA, Appelman LM, Feron VJ, and Van Der Heijden CA. Inhalation toxicity of acetaldehyhde in rats. II. Carcinogenicity study: Interim results after 15 months. Toxicology 1984; 31: 123-33.
7. Kerns WD, Pavkov KL, Donofrio DJ, Gralla EJ, and Swenberg JA. Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res 1983; 43: 4382-92.
8. Hurtt ME, Thomas DA, Working PK, Monticello TM, and Morgan KT. Degeneration and regeneration of the olfactory epithelium following inhalation exposure to methyl bromide: pathology, cell kinetics, and olfactory function. Toxicol Appl Pharmacol 1988; 94: 311-28.
9. Takeuchi T, Nagano K, Katagiri T, Aiso S, Okudaira M, and Fujiwara K. Increased incidence of foreign body rhinitis in F344 rats during two-year inhalation exposure to methyl bromide. J Toxcol Pathol 1997; 10: 145-8.
10. Buckley LA, Morgan KT, Swenberg JA, James RA, Hamm TE, and Barrow CS. The toxicity of dimethylamine in F344 rats and B6C3F1 mice following a 1-year inhalation exposure. Fund Appl Toxicol 1985; 5: 341-52.
11. Mery S, Larson JL, Butterworth BE, Wolf DC, Harden R, and Morgan KT. Nasal toxicity of chloroform in male F344 rats and female B6C3F1 mice following one week inhalation exposure. Toxicol Appl Pharmacol 1994; 125: 214-27.
12. Boorman G A, Morgan KT, and Uraih LC. Nose, Larynx and trachea. In: Pathology of the Fischer Rat. Boorman GA, Eustis SL, Elwell MR, Montgomery CA Jr., MacKenzie WF, eds, San Diego: Academic Press, 1990.
13. Clair MBG St and Morgan KT. Changes in the upper respiratory tract. In: Pathobiology of the Aging Rat, Vol. 1, Mohr U, Dungworth DL, Capen CC, eds. Washington; ILSI Press, 1992.
14. Coleman GL, Barthold SW, Osbaldiston GW, Foster SJ, and Jonas AM. Pathological changes during aging in barrierreared Fischer 344 male rats. J Gerontol 1977; 32: 258-78.
15. Goodman DO, Ward JM, Squire RA, Chu KC, and Linhart MS. Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol 1979; 48: 237-48.
16. Mohr U. Respiratory system. In: International classification of rodent tumours, part I-the rat, Mohr U. International agency for research on cancer(WHO). Lyon, IARC scientific publications, 1992.
17. Schwartz LW, Hahn FF, Keenan KP, Keenan CM, Brown HR, and Mann PC. Proliferative lesions of the rat respiratory tract. In: Standardized system of nomenclature and diagnostic criteria, guides for toxicologic pathology. Streett CS. STP/ARP/AFIP, Washington, DC.
18. Morgan KT and Monticello TM. Airflow, gas deposition, and lesion distribution in the nasal passages. Environ Health Perspect 1990; 88: 209-18.
19. Proctor DF and Chang JCF. Comparative anatomy and physiology of the nasal cavity. In: Nasal Tumors in Animals and Man, Vol 1, G Reznick, FS Sherman (eds), Florida, CRC Press, 1-33, 1983.
20. Reznik GK. Comparative anatomy, physiology, and function of the upper respiratory tract. Environ Health Perspect 1990; 85: 171-6.
21. Kuboyama Y, Mori K, Suzuki K, Ishii A, and Shuto K. Changes in nasal cavity volume and target area of exposure to nasal drops with age in rats. Exp Anim 1996; 45: 15-22.
22. Mery S, Gross EA, Joyner DR, Godo M, and Morgan KT. Nasal diagrams: A tool for recording the distribution of nasal lesions in rats and mice. Toxicol Pathol 1994; 22: 353-72.
23. Harkema JR and Morgan KT. The upper respiratory system. In: Monographs on Pathology of Laboratory Animals. Respiratory system, 2nd ed, Jones TC, Dungworth DL, and Mohr U eds, NewYork; Springer Press, 1996.