A naloxonazine sensitive (μ1 receptor) mechanism in the parabrachial nucleus modulates eating

Brain Research

Volumn 1240, Issue , 2008, Pages 111-118

  Chaijale, Nayla N ^a   Aloyo, Vincent J ^a   Simansky, Kenny J ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

1 opioid receptor; G protein coupling; Naloxonazine; Obesity; Opioids; Parabrachial nucleus

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MU 1 OPIATE RECEPTOR; MU 2 OPIATE RECEPTOR; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NALOXONAZINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; NALOXONE; NARCOTIC ANALGESIC AGENT; OPRM1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; BRAIN STEM; CONTROLLED STUDY; EATING; EX VIVO STUDY; FOOD INTAKE; MALE; NONHUMAN; PARABRACHIAL NUCLEUS; PONS; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; ANIMAL; DRUG EFFECT; FEEDING BEHAVIOR; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ANALGESICS, OPIOID; ANIMALS; AUTORADIOGRAPHY; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; FEEDING BEHAVIOR; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; NALOXONE; PONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU;

EID: 54549120172     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.08.066     Document Type: Article

References (41)

1. Atweh S.F., and Kuhar M.J. Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon. Brain Res. 134 (1977) 393-405
2. Bakshi V.P., and Kelley A.E. Feeding induced by opioid stimulation of the ventral striatum: role of opiate receptor subtypes. J. Pharmacol. Exp. Ther. 265 (1993) 1253-1260
3. Bodnar R.J. Endogenous opioids and feeding behavior: a 30-year historical perspective. Peptides 25 (2004) 697-725
4. Carr K.D., et al. Effects of parabrachial opioid antagonism on stimulation-induced feeding. Brain Res. 545 (1991) 283-286
5. Cole J.L., et al. Evaluation of chronic opioid receptor antagonist effects upon weight and intake measures in lean and obese Zucker rats. Peptides 18 (1997) 1201-1207
6. Fulwiler C.E., and Saper C.B. Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat. Brain Res. 319 (1984) 229-259
7. Giraudo S.Q., et al. Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the central nucleus of the amygdala and in the paraventricular nucleus in the rat. Brain Res. 782 (1998) 18-23
8. Glass M.J., et al. Opioids and food intake: distributed functional neural pathways?. Neuropeptides 33 (1999) 360-368
9. Goldberg I.E., et al. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J. Pharmacol. Exp. Ther. 286 (1998) 1007-1013
10. Goodman R.R., and Pasternak G.W. Visualization of mu1 opiate receptors in rat brain by using a computerized autoradiographic subtraction technique. Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 6667-6671
11. Hadjimarkou M.M., et al. Opioid receptor involvement in food deprivation-induced feeding: evaluation of selective antagonist and antisense oligodeoxynucleotide probe effects in mice and rats. J. Pharmacol. Exp. Ther. 311 (2004) 1188-1202
12. Hahn E.F., et al. Irreversible opiate agonists and antagonists: the 14-hydroxydihydromorphinone azines. J. Neurosci. 2 (1982) 572-576
13. Hahn E.F., and Pasternak G.W. Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites. Life Sci. 31 (1982) 1385-1388
14. Herbert H., et al. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J. Comp. Neurol. 293 (1990) 540-580
15. Hermann G.E., and Rogers R.C. Convergence of vagal and gustatory afferent input within the parabrachial nucleus of the rat. J. Auton. Nerv. Syst. 13 (1985) 1-17
16. Karimnamazi H., et al. Oral and gastric input to the parabrachial nucleus of the rat. Brain Res. 957 (2002) 193-206
17. Kelley A.E., et al. Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol. Behav. 86 (2005) 773-795
18. Kelley A.E., et al. Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats. J. Pharmacol. Exp. Ther. 278 (1996) 1499-1507
19. Kotz C.M., et al. Opioids in the nucleus of the solitary tract are involved in feeding in the rat. Am. J. Physiol. 272 (1997) R1028-R1032
20. Levine A.S. The animal model in food intake regulation: examples from the opioid literature. Physiol. Behav. 89 (2006) 92-96
21. Ling G.S., et al. Naloxonazine actions in vivo. Eur. J. Pharmacol. 129 (1986) 33-38
22. Lundy R., and Norgren R. Gustatory System. In: Paxinos G. (Ed). The Rat Nervous System. third ed. (2005), Elsevier Academic Press, San Diego 891-921
23. Mann P.E., et al. Differential sensitivity of opioid-induced feeding to naloxone and naloxonazine. Psychopharmacology (Berl) 94 (1988) 336-341
24. Mann P.E., et al. Comparison of effects of chronic administration of naloxone and naloxonazine upon food intake and maintainance of body weight in rats. Neuropharmacology 27 (1988) 349-355
25. Narita M., et al. Reduced expression of a novel μ-opioid receptor (MOR) subtype MOR-1B in CXBK mice: Implications of MOR-1B in the expression of MOR-mediated responses. Eur. J. Neurosci. 18 (2003) 3193-3198
26. Nicklous D.M., and Simansky K.J. Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (2003) R1046-R1054
27. Pan Y.-X., et al. Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm GENE. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 14084-14089
28. Pasternak G.W. Insights into mu opioid pharmacology: the role of mu opioid receptor subtypes. Life Sci. 68 (2001) 2213-2219
29. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. fourth ed. (1982), Academic Press, San Diego, USA
30. Ragnauth A., et al. Multiple opioid receptors mediate feeding elicited by mu and delta opioid receptor subtype agonists in the nucleus accumbens shell in rats. Brain Res. 876 (2000) 76-87
31. Sim L.J., Selley D.E., and Childers S.R. In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding. Proc. Natl. Acad. Sci. USA 92 (1995) 7242-7246
32. Simone D.A., et al. Involvement of opioid receptor subtypes in rat feeding behavior. Life Sci. 36 (1985) 829-833
33. Tanda G., and Di Chiara G. A dopamine-mu1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non-psychostimulant drugs of abuse. Eur. J. Neurosci. 10 (1998) 1179-1187
34. Ward H.G., and Simansky K.J. Chronic prevention of mu-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food. Psychopharmacology (Berl) 187 (2006) 435-446
35. Ward, H.G., Simansky, K.J., 2006. Regional specialization of mu-opioid receptors within the parabrachial nucleus of the pons in modulating eating. Society for Neuroscience annual meeting. Atlanta, GA
36. Ward H.G., et al. Mu-opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating. Eur. J. Neurosci. 23 (2006) 1605-1613
37. Wilson J.D., et al. An orexigenic role for mu-opioid receptors in the lateral parabrachial nucleus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (2003) R1055-R1065
38. Wolozin B.L., and Pasternak G.W. Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc. Natl. Acad. Sci. U. S. A. 78 (1981) 6181-6185
39. Zhang J., et al. The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist. Eur. J. Pharmacol. 545 (2006) 147-152
40. Zhang M., and Kelley A.E. Enhanced intake of high-fat food following striatal mu-opioid stimulation: microinjection mapping and fos expression. Neuroscience 99 (2000) 267-277
41. Zimprich A., et al. Cloning and expression of an isoform of the rat μ opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1. FEBS Lett. 359 (1995) 142-146