Magnesium treatment and spontaneous mild hypothermia after transient focal cerebral ischemia in the rat

Brain Research Bulletin

Volumn 77, Issue 5, 2008, Pages 320-322

  Campbell, Kym ^a   Meloni, Bruno P ^a   Zhu, Hongdong ^a   Knuckey, Neville W ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Cerebral ischemia; Hypothermia; Magnesium; Middle cerebral artery occlusion; Rat

Indexed keywords

MAGNESIUM SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; CONTROLLED STUDY; CORPUS STRIATUM; HYPOTHERMIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; SPRAGUE DAWLEY RAT; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; DISEASE MODELS, ANIMAL; HYPOTHERMIA; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MAGNESIUM; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 54549117166     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2008.08.017     Document Type: Article

References (11)

1. Campbell K., Meloni B.P., and Knuckey N.W. Combined magnesium and mild hypothermia (35 °C) treatment reduces infarct volumes after permanent middle cerebral artery occlusion in the rat at 2 and 4, but not 6 h. Brain Res. 1230 (2008) 258-264
2. Campbell K., Meloni B.P., and Knuckey N.W. The effect of hypothermia in combination therapies for cerebral ischaemia. Int. J. Neuroprot. Neuroregener. 3 (2007) 210-224
3. Intravenous Magnesium Efficacy in Stroke (IMAGES) Study Investigators. Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet 363 (2004) 439-445
4. Kim Y., Busto R., Dietrich W.D., Kraydieh S., and Ginsberg M.D. Delayed postischemic hyperthermia in awake rats worsens the histopathological outcome of transient focal cerebral ischemia. Stroke 27 (1996) 2274-2281
5. Li F., Omae T., and Fisher M. Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats. Stroke 30 (1999) 2464-2471
6. Meloni B.P., Zhu H., and Knuckey N.W. Is magnesium neuroprotective following global and focal cerebral ischaemia? A review of published studies. Magnesium Res. 19 (2006) 123-137
7. Saver J.L., Kidwell C., Eckstein M., and Starkmam S. Prehospital neuroprotective therapy for acute stroke: results of the field administration of stroke therapy-magnesium (FAST-MAG) pilot trial. Stroke 35 (2004) e106-e108
8. Westermaier T., Zausinger S., Baethmann A., and Schmid-Elsaesser R. Dose finding study of intravenous magnesium sulphate in transient focal cerebral ischemia in rats. Acta Neurochir. 147 (2005) 525-532
9. Zhu H., Meloni B.P., Bojarski C., Knuckey M.W., and Knuckey N.W. Post-ischemic modest hypothermia (35C) combined with intravenous magnesium is more effective at reducing CA1 neuronal death than either treatment used alone following global cerebral ischemia in rats. Exp. Neurol. 193 (2005) 361-368
10. Zhu H., Meloni B.P., Moore S.R., Majda B.T., and Knuckey N.W. Intravenous administration of magnesium is only neuroprotective following transient global ischemia when present with post-ischemic mild hypothermia. Brain Res. 1014 (2004) 53-60
11. Zhu H., Martin R., Meloni B.P., Oltvolgyi C., Moore S.R., Majda B.T., and Knuckey N.W. Magnesium sulfate fails to reduce infarct volume following transient focal cerebral ischemia in rats. Neurosci. Res. 49 (2004) 347-353