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Volumn 36, Issue 10, 2008, Pages 2956-2958

Rigorous genotype-phenotype association research depends on scientific rigor at multiple scales of investigation

Author keywords

Experimental design; Functional genomics; Genotype; Phenotype

Indexed keywords

CRITICAL ILLNESS; CYTOLOGY; DATA BASE; DOCTOR PATIENT RELATION; EDITORIAL; EPIGENETICS; FUNCTIONAL GENOMICS; GENOTYPE PHENOTYPE CORRELATION; HOLISTIC CARE; INJURY; MEDICAL INFORMATICS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ANIMAL; GENETICS; GENOMICS; GENOTYPE; HUMAN; INTENSIVE CARE; NOTE; PHENOTYPE; PROTEOMICS; STANDARD; TOTAL QUALITY MANAGEMENT;

EID: 54549113485     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318187b834     Document Type: Editorial
Times cited : (1)

References (23)
  • 1
    • 67650380741 scopus 로고    scopus 로고
    • Mandelbrot B: The Fractal Geometry of Nature. Ed. New York, W. H. Freeman and Company, 1983
    • Mandelbrot B: The Fractal Geometry of Nature. Ed. New York, W. H. Freeman and Company, 1983
  • 2
    • 67650352914 scopus 로고    scopus 로고
    • Morris A: Algorithm-based decision making. In: Tobin M (Ed). Principles and Practice of Intensive Care Monitoring. Ed. New York, McGraw-Hill, 1998, 1355-1381
    • Morris A: Algorithm-based decision making. In: Tobin M (Ed). Principles and Practice of Intensive Care Monitoring. Ed. New York, McGraw-Hill, 1998, 1355-1381
  • 3
    • 0024321898 scopus 로고
    • Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction
    • The Cardiac Arrhythmia Suppression Trial (CAST) Investigators
    • The Cardiac Arrhythmia Suppression Trial (CAST) Investigators: Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med 1989; 321:406-412
    • (1989) N Engl J Med , vol.321 , pp. 406-412
  • 4
    • 0026752875 scopus 로고
    • Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction
    • The Cardiac Arrhythmia Suppression Trial II Investigators
    • The Cardiac Arrhythmia Suppression Trial II Investigators: Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med 1992; 327:227-233
    • (1992) N Engl J Med , vol.327 , pp. 227-233
  • 5
    • 0025176911 scopus 로고
    • Clinical and regulatory implications of the cardiac arrhythmia suppression trial [editorial]
    • Pratt C, Brater D, Harrell F Jr, et al: Clinical and regulatory implications of the cardiac arrhythmia suppression trial [editorial]. Am J Cardiol 1990; 65:103-105
    • (1990) Am J Cardiol , vol.65 , pp. 103-105
    • Pratt, C.1    Brater, D.2    Harrell Jr, F.3
  • 6
    • 0032533870 scopus 로고    scopus 로고
    • Novel arterial pathology in mice and humans hemizygous for elastin
    • Li DY, Faury G, Taylor DG, et al: Novel arterial pathology in mice and humans hemizygous for elastin. J Clin Invest 1998; 102:1783-1787
    • (1998) J Clin Invest , vol.102 , pp. 1783-1787
    • Li, D.Y.1    Faury, G.2    Taylor, D.G.3
  • 7
    • 0036960143 scopus 로고    scopus 로고
    • Theories in early embryology: Close connections between epigenesis, preformation-ism, and self-organization
    • van Speybroeck L, de Waele D, van de Vijver G: Theories in early embryology: Close connections between epigenesis, preformation-ism, and self-organization. Ann N Y Acad Sci 2002; 981:7-49
    • (2002) Ann N Y Acad Sci , vol.981 , pp. 7-49
    • van Speybroeck, L.1    de Waele, D.2    van de Vijver, G.3
  • 8
    • 0036963888 scopus 로고    scopus 로고
    • The genome in its ecological context: Philosophical perspectives on interspecies epigenesis
    • Gilbert SF: The genome in its ecological context: Philosophical perspectives on interspecies epigenesis. Ann N Y Acad Sci 2002; 981: 202-218
    • (2002) Ann N Y Acad Sci , vol.981 , pp. 202-218
    • Gilbert, S.F.1
  • 10
    • 54549118323 scopus 로고    scopus 로고
    • Cobb JP, Suffredini A, Danner RL: The Fourth National Institutes of Health Symposium on the Functional Genomics of Critical Injury: Surviving stress from organ systems to molecules. Crit Care Med 2008; 36:2905-2911
    • Cobb JP, Suffredini A, Danner RL: The Fourth National Institutes of Health Symposium on the Functional Genomics of Critical Injury: Surviving stress from organ systems to molecules. Crit Care Med 2008; 36:2905-2911
  • 11
    • 0030502423 scopus 로고    scopus 로고
    • Homeostasis, humpty dumpty, and integrative biology
    • Schultz S: Homeostasis, humpty dumpty, and integrative biology. News Physiol Sci 1996; 11:238-246
    • (1996) News Physiol Sci , vol.11 , pp. 238-246
    • Schultz, S.1
  • 12
    • 67650377910 scopus 로고    scopus 로고
    • Campbell D, Stanley J: Experimental and quasi-experimental designs for research (reprinted from Handbook of Research on Teaching, 1963). Ed. Boston, Houghton Mifflin Co., 1966
    • Campbell D, Stanley J: Experimental and quasi-experimental designs for research (reprinted from Handbook of Research on Teaching, 1963). Ed. Boston, Houghton Mifflin Co., 1966
  • 14
    • 0027368467 scopus 로고
    • User's guide to the medical literature: II. How to use an article about therapy or prevention; A. Are the results of the study valid? Evidence-Based Medicine Working Group
    • Guyatt G, Sackett D, Cook D: User's guide to the medical literature: II. How to use an article about therapy or prevention; A. Are the results of the study valid? Evidence-Based Medicine Working Group. JAMA 1993; 270:2598-2601
    • (1993) JAMA , vol.270 , pp. 2598-2601
    • Guyatt, G.1    Sackett, D.2    Cook, D.3
  • 15
    • 0028047157 scopus 로고
    • User's guide to the medical literature: II. How to use and article about therapy or prevention; B. What were the results and will they help me in caring for my patient?
    • Guyatt G, Sackett D, Cook D: User's guide to the medical literature: II. How to use and article about therapy or prevention; B. What were the results and will they help me in caring for my patient? JAMA 1994; 271:59-63
    • (1994) JAMA , vol.271 , pp. 59-63
    • Guyatt, G.1    Sackett, D.2    Cook, D.3
  • 16
    • 0033574245 scopus 로고    scopus 로고
    • Assessing the generalizability of prognostic information
    • Justice AC, Covinsky KE, Berlin JA: Assessing the generalizability of prognostic information. Ann Intern Med 1999; 130:515-524
    • (1999) Ann Intern Med , vol.130 , pp. 515-524
    • Justice, A.C.1    Covinsky, K.E.2    Berlin, J.A.3
  • 17
    • 0034737962 scopus 로고    scopus 로고
    • What makes clinical research ethical?
    • Emanuel EJ, Wendler D, Grady C: What makes clinical research ethical? JAMA 2000; 283:2701-2711
    • (2000) JAMA , vol.283 , pp. 2701-2711
    • Emanuel, E.J.1    Wendler, D.2    Grady, C.3
  • 18
    • 67650356406 scopus 로고    scopus 로고
    • Barrow JD: The Book of Nothing. Ed. New York, Pantheon Books, 2000
    • Barrow JD: The Book of Nothing. Ed. New York, Pantheon Books, 2000
  • 19
    • 3042738109 scopus 로고    scopus 로고
    • Complex interventions: How "out of control" can a randomised controlled trial be?
    • Hawe P, Shiell A, Riley T: Complex interventions: How "out of control" can a randomised controlled trial be? BMJ 2004; 328:1561-1563
    • (2004) BMJ , vol.328 , pp. 1561-1563
    • Hawe, P.1    Shiell, A.2    Riley, T.3
  • 20
    • 34250802746 scopus 로고    scopus 로고
    • The importance of protocol-directed patient management for research on lung-protective ventilation
    • Dreyfuss D, Saumon G, Hubamyr R Eds, New York, Taylor & Francis Group
    • Morris A: The importance of protocol-directed patient management for research on lung-protective ventilation. In: Ventilator-Induced Lung Injury. Dreyfuss D, Saumon G, Hubamyr R (Eds). New York, Taylor & Francis Group, 2006, 537-610
    • (2006) Ventilator-Induced Lung Injury , pp. 537-610
    • Morris, A.1
  • 21
    • 0034104226 scopus 로고    scopus 로고
    • Developing and implementing computerized protocols for standardization of clinical decisions
    • Morris A: Developing and implementing computerized protocols for standardization of clinical decisions. Ann Intern Med 2000; 132:373-383
    • (2000) Ann Intern Med , vol.132 , pp. 373-383
    • Morris, A.1
  • 22
    • 61949474255 scopus 로고    scopus 로고
    • Computerized protocols to assist clinical research
    • Olsen L, Aisner D, McGinnis JM Eds, Washington, DC, The National Academies Press, to
    • Morris AH: Computerized protocols to assist clinical research. In: The Learning Healthcare System: Workshop Summary (Roundtable on Evidence-Based Medicine). Olsen L, Aisner D, McGinnis JM (Eds). Washington, DC, The National Academies Press, 2007, pp 1-19 to 1-35
    • (2007) The Learning Healthcare System: Workshop Summary (Roundtable on Evidence-Based Medicine)
    • Morris, A.H.1
  • 23
    • 45149133258 scopus 로고    scopus 로고
    • A replicable method for blood glucose control in critically ill patients
    • Morris A, Orme J Jr, Truwit J, et al: A replicable method for blood glucose control in critically ill patients. Crit Care Med 2008; 36:1787-1795
    • (2008) Crit Care Med , vol.36 , pp. 1787-1795
    • Morris, A.1    Orme Jr, J.2    Truwit, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.