The Fourth National Institutes of Health Symposium on the Functional Genomics of Critical Injury: Surviving stress from organ systems to molecules

Critical Care Medicine

Volumn 36, Issue 10, 2008, Pages 2905-2911

  Cobb, J Perren ^a   Suffredini, Anthony F ^b   Danner, Robert L ^b  

^a WASHINGTON UNIVERSITY   (United States)

^b Blood Services Section   (United States)

Author keywords

Organ failure; Septic shock; Stress; Systems biology; Trauma

Indexed keywords

ARGINASE; ARGININE; BLOOD CLOTTING FACTOR; FATTY ACID; FRESH FROZEN PLASMA; GLUCOCORTICOID RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; IRINOTECAN; MERCAPTOPURINE; NITRIC OXIDE; NITRITE; TUMOR NECROSIS FACTOR ALPHA; WARFARIN;

ANTIBIOTIC PROPHYLAXIS; BLAST INJURY; BLOOD CLOTTING DISORDER; BLOOD VESSEL; CHILD HEALTH CARE; CHILDHOOD LEUKEMIA; CLINICAL PRACTICE; COLORECTAL CANCER; COMMUNITY; CONSENSUS; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DISEASE MODEL; DRUG LABELING; ENTERITIS; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME ANALYSIS; HEALTH CARE PERSONNEL; HIGH THROUGHPUT SCREENING; HUMAN; IMMUNE RESPONSE; INFECTION SENSITIVITY; INFLAMMATION; INJURY; INTENSIVE CARE; MATHEMATICAL MODEL; METABOLIC SYNDROME X; MOLECULAR INTERACTION; NEUROPROTECTION; NITRATION; NONHUMAN; PATIENT CARE; PHARMACOGENOMICS; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEOMICS; RESEARCH; REVIEW; SICKLE CELL ANEMIA; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE TRANSFUSION; TRANSCRIPTOMICS; TRANSLATION INITIATION; TRAUMATIC BRAIN INJURY; BIOLOGY; CONFERENCE PAPER; CONSENSUS DEVELOPMENT; FEMALE; GENETICS; GENOMICS; INJURY SCALE; MALE; MORTALITY; PATHOPHYSIOLOGY; PHARMACOGENETICS; SENSITIVITY AND SPECIFICITY; STANDARD; STRESS; SURVIVAL RATE; SYSTEMS BIOLOGY; UNITED STATES;

COMPUTATIONAL BIOLOGY; CRITICAL CARE; CRITICAL ILLNESS; FEMALE; GENOMICS; HUMANS; INJURY SEVERITY SCORE; MALE; PHARMACOGENETICS; PROTEOMICS; RESEARCH; SENSITIVITY AND SPECIFICITY; STRESS; SURVIVAL RATE; SYSTEMS BIOLOGY; UNITED STATES; WOUNDS AND INJURIES;

EID: 54549118323     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318186a720     Document Type: Review

References (59)

1. Cobb JP, Mindrinos MN, Miller-Graziano C, et al: Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci USA 2005; 102:4801-4806
2. Functional genomics of critical illness and injury: Surviving stress, organ systems to molecules. Available at: http://www.strategicresults.com/ fg4/, Accessed March 26, 2007.
3. Guimera R, Nunes Amaral LA: Functional cartography of complex metabolic networks. Nature 2005; 433:895-900
4. Eisenhofer G, Kopin IJ, Goldstein DS: Catecholamine metabolism: A contemporary view with implications for physiology and medicine. Pharmacol Rev 2004; 56:331-349
5. Goldstein DS: Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine. Baltimore, MD, The Johns Hopkins University Press, 2006
6. Oltvai ZN, Barabasi AL: Systems biology. Life's complexity pyramid. Science 2002; 298:763-764
7. Cobb JP, O'Keefe GE: Injury research in the genomic era. Lancet 2004; 363:2076-2083
8. Chung TP, Laramie JM, Meyer DJ, et al: Molecular diagnostics in sepsis: From bedside to bench. J Am Coll Surg 2006; 203:585-598
9. Ramilo O, Allman W, Chung W, et al: Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood 2007; 109:2066-2077
10. Mendis C, Das R, Hammamieh R, et al: Transcriptional response signature of human lymphoid cells to staphylococcal enterotoxin B. Genes Immun 2005; 6:84-94
11. Paranavitana CM, Zelazowska E, Das R, et al: Identification of novel genes in the memory response to Brucella infection by cDNA arrays. Mol Cell Probes 2005; 19:341-348
12. Royaee AR, Mendis C, Das R, et al: Cholera toxin induced gene expression alterations. Mol Immunol 2006; 43:702-709
13. van Gessel YA, Mani S, Bi S, et al: Functional piglet model for the clinical syndrome and postmortem findings induced by staphylococcal enterotoxin B. Exp Biol Med (Maywood) 2004; 229:1061-1071
14. Garvey TD, Lincoln P, Pedersen CJ, et al: BioSPICE: Access to the most current computational tools for biologists. OMICS 2003; 7:411-420
15. Coombes KR, Morris JS, Hu J, et al: Serum proteomics profiling - A young technology begins to mature. Nat Biotechnol 2005; 23: 291-292
16. Baggerly KA, Morris JS, Edmonson SR, et al: Signal in noise: Evaluating reported repro-ducibility of serum proteomic tests for ovarian cancer. J Natl Cancer Inst 2005; 97: 307-309
17. Hu J, Coombes KR, Morris JS, et al: The importance of experimental design in proteomic mass spectrometry experiments: Some cautionary tales. Brief Funct Genomic Proteomic 2005; 3:322-331
18. Prass K, Meisel C, Hoflich C, et al. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med 2003; 198:725-736
19. Meisel C, Schwab JM, Prass K, et al: Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci 2005; 6:775-786
20. Prass K, Braun JS, Dirnagl U, et al: Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia. Stroke 2006; 37:2607-2612
21. Dirnagl U, Klehmet J, Braun JS, et al: Strokeinduced immunodepression: Experimental evidence and clinical relevance. Stroke 2007; 38:770-773
22. Hornero R, Aboy M, Abasolo D, et al: Complex analysis of intracranial hypertension using approximate entropy. Crit Care Med 2006; 34:87-95
23. Goldstein B: Heart rate characteristics in neonatal sepsis: A promising test that is still premature. Pediatrics 2005; 115:1070-1072
24. Sharp FR, Xu H, Lit L, et al: The future of genomic profiling of neurological diseases using blood. Arch Neurol 2006; 63: 1529-1536
25. Sharp FR, Xu H, Lit L, et al: Genomic profiles of stroke in blood. Stroke 2007; 38:691-693
26. Duma D, Jewell CM, Cidlowski JA: Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification. J Steroid Biochem Mol Biol 2006; 102:11-21
27. Lewis-Tuffin, LJ, Jewell CM, Bienstock RJ, et al: Human glucocorticoid receptor {beta} (hGR{beta}) binds RU-486 and is transcriptionally active. Mol Cell Biol 2007; 27: 2266-2282
28. Gladwin MT: Nitrite as an intrinsic signaling molecule. Nat Chem Biol 2005; 1:245-246
29. Gladwin MT: Hemoglobin as a nitrite reductase regulating red cell-dependent hypoxic vasodilation. Am J Respir Cell Mol Biol 2005; 32:363-366
30. Dias-Junior CA, Gladwin MT, Tanus-Santos JE: Low-dose intravenous nitrite improves hemodynamics in a canine model of acute pulmonary thromboembolism. Free Radic Biol Med 2006; 41:1764-1770
31. Baker PR, Lin Y, Schopfer FJ, et al: Fatty acid transduction of nitric oxide signaling: Multi- ple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands. J Biol Chem 2005; 280:42464-42475
32. Cui T, Schopfer FJ, Zhang J, et al: Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. J Biol Chem 2006; 281: 35686-35698
33. Morris SM Jr: Arginine metabolism in vascular biology and disease. Vasc Med 2005; 10 (Suppl 1):S83-S87
34. Morris SM Jr: Arginine: Beyond protein. Am J Clin Nutr 2006; 83:508S-512S
35. Morris CR, Kato GJ, Poljakovic M, et al: Dys-regulated arginine metabolism, hemolysisassociated pulmonary hypertension, and mortality in sickle cell disease. JAMA 2005; 294:81-90
36. Raghavachari N, Xu X, Harris A, et al: Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation 2007; 115:1151-1162
37. NIH genome-wide association studies (GWAS). Available at: http://grants2.nih.gov/ grants/gwas/, Accessed March 23, 2007
38. Yang RZ, Lee MJ, Hu H, et al: Identification of omentin as a novel depot-specific adipokine in human adipose tissue: Possible role in modulating insulin action. Am J Physiol Endocrinol Metab 2006; 290:E1253-E1261
39. de Souza Batista CM, Yang RZ, Lee MJ, et al: Omentin plasma levels and gene expression are decreased in obesity. Diabetes 2007; 56: 1655-1661
40. The Amish pharmacogenomics of antiplatelet intervention study. Available at: http://www.pharmgkb.org/network/members/ papi.jsp, Accessed March 23, 2007
41. Roden DM, Altman RB, Benowitz NL, et al: Pharmacogenomics: Challenges and opportunities. Ann Intern Med 2006; 145:749-757
42. Weinshilboum RM, Wang L: Pharmacogenetics and pharmacogenomics: Development, science, and translation. Annu Rev Genomics Hum Genet 2006; 7:223-245
43. Pharmacogenetics research network. Available at: http://www.nigms.nih. gov/Initiatives/ PGRN/, Accessed March 23, 2007
44. Canadian critical care trials group. Available at: http://www.ccctg.ca/ index.php, Accessed March 23, 2007
45. Hebert PC, Wells G, Blajchman MA, et al: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion requirements in critical care investigators, Canadian critical care trials group. N Engl J Med 1999; 340:409-417
46. Cook D, Rocker G, Marshall J, et al: Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med 2003; 349:1123-1132
47. Canadian Critical Care Trials Group. A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med 2006; 355:2619-2630
48. US Army Medical Research and Materiel Command. Available at: https://mrmc.amedd. army.mil/. Accessed March 26, 2007
49. Kauvar DS, Holcomb JB, Norris GC, et al: Fresh whole blood transfusion: A controversial military practice. J Trauma 2006; 61: 181-184
50. The National Collaborative Pediatric Critical Care Research Network. Available at: http:// www.cpccrn.org/. Accessed March 26, 2007
51. Inflammation and the host response to injury. Available at: http://www.gluegrant.org/. Accessed March 26, 2007
52. Australian and New Zealand Intensive Care Society (ANZICS). Available at: http:// www.anzics.com.au/. Accessed March 26, 2007.
53. Finfer S, Bellomo R, Boyce N, et al: A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004; 350:2247-2256
54. German National Genome Research Network (NGFN). Available at: http://www.ngfn.de/ englisch/index.htm. Accessed March 26, 2007
55. Menges T, König IR, Hossain H, et al: Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor. Crit Care Med 2008; 36:1456-1462
56. NINDS Clinical Research Collaboration. Available at: http://www.ninds. nih.gov/ funding/research/clinical-research/crc.htm. Accessed May 3, 2007
57. Critical Illness and Injury NIH Special Interest Group. Available at: http://www.nih.gov/ sigs/cii. Accessed May 3, 2007
58. United States Critical Illness and Injury Trials Group. Available at: http://public.wudosis. wustl.edu/USCIITG/default.aspx, Accessed January 24, 2008
59. Morris AH: The importance of protocol-directed patient management for research on lung-protective ventilation. In: Ventilator-Induced Lung Injury. Dereyfuss D, Saumon G, Hubamyr R (Eds). New York, Taylor & Francis Group, 2006, pp 537-610