Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: An approach for rational drug design

Journal of Antimicrobial Chemotherapy

Volumn 62, Issue 5, 2008, Pages 998-1002

  Misra, Pragya ^a   Khaliq, Tanvir ^a   Dixit, Anshuman ^a   SenGupta, Souvik ^b   Samant, Mukesh ^a   Kumari, Shraddha ^a   Kumar, Awanish ^a   Kushawaha, Pramod K ^a   Majumder, H K ^b   Saxena, Anil K ^a   Narender, T ^a   Dube, Anuradha ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Apoptosis; Mitochondrial transmembrane potential; Molecular docking; TUNEL assay

Indexed keywords

DNA TOPOISOMERASE; HERBACEOUS AGENT; PEGANINE HYDROCHLORIDE DIHYDRATE; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; APOPTOSIS; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG DNA INTERACTION; DRUG ISOLATION; DRUG SAFETY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; LEISHMANIA DONOVANI; MITOCHONDRIAL MEMBRANE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NICK END LABELING; NONHUMAN; PEGANUM HARMALA; PLANT SEED; STRUCTURE ANALYSIS; VISCERAL LEISHMANIASIS;

ALKALOIDS; ANIMALS; ANTIPROTOZOAL AGENTS; APOPTOSIS; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; DRUG DESIGN; LEISHMANIA DONOVANI; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 54549098202     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkn319     Document Type: Article

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