Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1

Genes to Cells

Volumn 13, Issue 11, 2008, Pages 1113-1126

  Koyama, Hiroshi ^a   Sumiya, Eriko ^a   Nagata, Makiko ^a   Ito, Takahiro ^a   Sekimizu, Kazuhisa ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; ELONGATION FACTOR; INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE 2; MENADIONE; MYCOPHENOLIC ACID; TIABENDAZOLE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SUB1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENETIC TRANSCRIPTION; NONHUMAN; OPEN READING FRAME; PLEIOTROPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; YEAST CELL;

DNA-BINDING PROTEINS; GENE EXPRESSION; GENES, FUNGAL; IMP DEHYDROGENASE; MUTATION; PROMOTER REGIONS, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

SACCHAROMYCETALES;

EID: 54449091546     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2008.01229.x     Document Type: Article

References (42)

1. Awrey, D.E., Weilbaecher, R.G., Hemming, S.A., Orlicky, S.M., Kane, C.M. & Edwards, A.M. (1997) Transcription elongation through DNA arrest sites. A multistep process involving both RNA polymerase II subunit RPB9 and TFIIS. J. Biol. Chem. 272, 14747-14754.
2. Calvo, O. & Manley, J.L. (2001) Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. Mol. Cell 7, 1013-1023.
3. Calvo, O. & Manley, J.L. (2005) The transcriptional coactivator PC4/ Sub1 has multiple functions in RNA polymerase II transcription. EMBO J. 24, 1009-1020.
4. Costa, P.J. & Arndt, K.M. (2000) Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. Genetics 156, 535-547.
5. Davis, C.A. & Ares, M., Jr (2006) Accumulation of unstable promoter-associated transcripts upon loss of the nuclear exosome subunit Rrp6p in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 103, 3262-3267.
6. Desmoucelles, C., Pinson, B., Saint-Marc, C. & Daignan-Fornier, B. (2002) Screening the yeast "disruptome"for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid. J. Biol. Chem. 277, 27036-27044.
7. Escobar-Henriques, M. & Daignan-Fornier, B. (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J. Biol. Chem. 276, 1523-1530.
8. Escobar-Henriques, M., Collart, M.A. & Daignan-Fornier, B. (2003a) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol. Cell. Biol. 23, 6279-6290.
9. Escobar-Henriques, M., Daignan-Fornier, B. & Collart, M.A. (2003b) The critical cis -acting element required for IMD2 feedback regulation by GDP is a TATA box located 202 nucleotides upstream of the transcription start site. Mol. Cell. Biol. 23, 6267-6278.
10. Exinger, F. & Lacroute, F. (1992) 6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae. Curr. Genet. 22, 9-11.
11. Fukuda, A., Tokonabe, S., Hamada, M., Matsumoto, M., Tsukui, T., Nogi, Y. & Hisatake, K. (2003) Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH. J. Biol. Chem. 278, 14827-14831.
12. Ge, H. & Roeder, R.G. (1994) Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78, 513-523.
13. Hemming, S.A., Jansma, D.B., Macgregor, P.F., Goryachev, A., Friesen, J.D. & Edwards, A.M. (2000) RNA polymerase II subunit Rpb9 regulates transcription elongation in vivo. J. Biol. Chem. 275, 35506-35511.
14. Henry, N.L., Bushnell, D.A. & Kornberg, R.D. (1996) A yeast transcriptional stimulatory protein similar to human PC4. J. Biol. Chem. 271, 21842-21847.
15. Hyle, J.W., Shaw, R.J. & Reines, D. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J. Biol. Chem. 278, 28470-28478.
16. Jenks, M.H., O'Rourke, T.W. & Reines, D. (2008) Properties of an intergenic terminator and start site switch that regulate IMD2 transcription in yeast. Mol. Cell. Biol. 28, 3883-3893.
17. Kawamura, N., Kurokawa, K., Ito, T., Hamamoto, H., Koyama, H., Kaito, C. & Sekimizu, K. (2005) Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation. Genes Cells 10, 477-487.
18. Knaus, R., Pollock, R. & Guarente, L. (1996) Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4. EMBO J. 15, 1933-1940.
19. Kopcewicz, K.A., O'Rourke, T.W. & Reines, D. (2007) Metabolic regulation of IMD2 transcription and an unusual DNA element that generates short transcripts. Mol. Cell. Biol. 27, 2821-2829.
20. Koyama, H., Ito, T., Nakanishi, T. & Sekimizu, K. (2007a) Stimulation of RNA polymerase II transcript cleavage activity contributes to maintain transcriptional fidelity in yeast. Genes Cells 12, 547-559.
21. Koyama, H., Ito, T., Nakanishi, T., Kawamura, N. & Sekimizu, K. (2003) Transcription elongation factor S-II maintains transcriptional fidelity and confers oxidative stress resistance. Genes Cells 8, 779-788.
22. Koyama, H., Sumiya, E., Ito, T. & Sekimizu, K. (2007b) Improved method for the PCR-based gene disruption in Saccharomyces cerevisiae. FEMS Yeast Res. Published Online.
23. Kretzschmar, M., Kaiser, K., Lottspeich, F. & Meisterernst, M. (1994) A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Cell 78, 525-534.
24. Malagon, F., Tong, A.H., Shafer, B.K. & Strathern, J.N. (2004) Genetic interactions of DST1 in Saccharomyces cerevisiae suggest a role of TFIIS in the initiation-elongation transition. Genetics 166, 1215-1227.
25. McPhillips, C.C., Hyle, J.W. & Reines, D. (2004) Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo. Proc. Natl. Acad. Sci. USA 101, 12171-12176.
26. Nakanishi, T., Nakano, A., Nomura, K., Sekimizu, K. & Natori, S. (1992) Purification, gene cloning, and gene disruption of the transcription elongation factor S-II in Saccharomyces cerevisiae. J. Biol. Chem. 267, 13200-13204.
27. Ohya, Y., Goebl, M., Goodman, L.E., Petersen-Bjorn, S., Friesen, J.D., Tamanoi, F. & Anraku, Y. (1991) Yeast CAL1 is a structural and functional homologue to the DPR1 (RAM) gene involved in ras processing. J. Biol. Chem. 266, 12356-12360.
28. Pinto, I., Ware, D.E. & Hampsey, M. (1992) The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo. Cell 68, 977-988.
29. Reines, D. & Mote, J. Jr (1993) Elongation factor SII-dependent transcription by RNA polymerase II through a sequence-specific DNA-binding protein. Proc. Natl. Acad. Sci. USA 90, 1917-1921.
30. Reines, D., Chamberlin, M.J. & Kane, C.M. (1989) Transcription elongation factor SII (TFIIS) enables RNA polymerase II to elongate through a block to transcription in a human gene in vitro. J. Biol. Chem. 264, 10799-10809.
31. Riles, L., Shaw, R.J., Johnston, M. & Reines, D. (2004) Large-scale screening of yeast mutants for sensitivity to the IMP dehydrogenase inhibitor 6-azauracil. Yeast 21, 241-248.
32. Schang, L.M., Hwang, G.J., Dynlacht, B.D., Speicher, D.W., Bantly, A., Schaffer, P.A., Shilatifard, A., Ge, H. & Shiekhattar, R. (2000) Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylation. J. Biol. Chem. 275, 6071-6074.
33. Shaw, R.J. & Reines, D. (2000) Saccharomyces cerevisiae transcription elongation mutants are defective in PUR5 induction in response to nucleotide depletion. Mol. Cell. Biol. 20, 7427-7437.
34. Shaw, R.J., Wilson, J.L., Smith, K.T. & Reines, D. (2001) Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast. J. Biol. Chem. 276, 32905-32916.
35. Steinmetz, E.J., Warren, C.L., Kuehner, J.N., Panbehi, B., Ansari, A.Z. & Brow, D.A. (2006) Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase. Mol. Cell 24, 735-746.
36. Sun, Z.W., Tessmer, A. & Hampsey, M. (1996) Functional interaction between TFIIB and the Rpb9 (Ssu73) subunit of RNA polymerase II in Saccharomyces cerevisiae. Nucleic Acids Res. 24, 2560-2566.
37. Ubukata, T., Shimizu, T., Adachi, N., Sekimizu, K. & Nakanishi, T. (2002) Cleavage, but not read-through, stimulation activity is responsible for three biologic functions of transcription elongation factor S-II. J. Biol. Chem. 278, 8580-8585.
38. Van Mullem, V., Wery, M., Werner, M., Vandenhaute, J. & Thuriaux, P. (2002) The Rpb9 subunit of RNA polymerase II binds transcription factor TFIIE and interferes with the SAGA and elongator histone acetyltransferases. J. Biol. Chem. 277, 10220-10225.
39. Wang, Z. & Roeder, R.G. (1998) DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III. Mol. Cell 1, 749-757.
40. Werten, S., Stelzer, G., Goppelt, A., Langen, F.M., Gros, P., Timmers, H.T., Van der Vliet, P.C. & Meisterernst, M. (1998) Interaction of PC4 with melted DNA inhibits transcription. EMBO J. 17, 5103-5111.
41. Wery, M., Shematorova, E., Van Driessche, B., Vandenhaute, J., Thuriaux, P. & Van Mullem, V. (2004) Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS. EMBO J. 23, 4232-4242.
42. Wu, W.H., Pinto, I., Chen, B.S. & Hampsey, M. (1999) Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB. Genetics 153, 643-652.