Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6

Journal of Cell Science

Volumn 117, Issue 19, 2004, Pages 4495-4508

  Hasegawa, Haruki ^a   Yang, Zhifen ^a   Oltedal, Leif ^b   Davanger, Svend ^c   Hay, Jesse C ^a,d  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF BERGEN   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d UNIVERSITY OF MONTANA   (United States)

Author keywords

Protein palmitoylation; Protein prenylation; SNAP receptor; SNARE; Vesicle transport; Ykt6

Indexed keywords

SNARE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HYDROPHOBICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PALMITOYLATION; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SURFACE PROPERTY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; HIPPOCAMPUS; LIPID METABOLISM; MEMBRANE PROTEINS; MEMBRANES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTATION; NEUROGLIA; NEURONS; PROTEIN BINDING; PROTEIN TRANSPORT; R-SNARE PROTEINS; RATS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SNARE PROTEINS; TUMOR CELLS, CULTURED; VESICULAR TRANSPORT PROTEINS;

ANIMALIA; INSERTION SEQUENCES; MAMMALIA;

EID: 5444272879     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01314     Document Type: Article

References (32)

1. Dietrich, L. E., Boeddinghaus, C., LaGrassa, T. J. and Ungermann, C. (2003). Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins. Biochim. Biophys. Acta 1641, 111-119.
2. Dietrich, L. E., Gurezka, R., Veit, M. and Ungermann, C. (2004). The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion. EMBO J. 23, 45-53.
3. Dilcher, M., Kohler, B. and Fischer von Mollard, G. (2001). Genetic interactions with the yeast Q-SNARE VTI1 reveal novel functions for the R-SNARE YKT6. J. Biol. Chem. 276, 34537-34544.
4. Dulubova, I., Yamaguchi, T., Gao, Y., Min, S. W., Huryeva, I., Sudhof, T. C. and Rizo, J. (2002). How T1g2p/syntaxin 16 'snares' Vps45. EMBO J. 21, 3620-3631.
5. Fasshauer, D., Sutton, R. B., Brunger, A. T. and Jahn, R. (1998). Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs. Proc. Natl. Acad. Sci. USA 95, 15781-15786.
6. Filippini, F., Rossi, V., Galli, T., Budillon, A., D'Urso, M. and D'Esposito, M. (2001). Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain. Trends Biochem. Sci. 26, 407-409.
7. Gedeon, A. K., Colley, A., Jamieson, R., Thompson, E. M., Rogers, J., Sillence, D., Tiller, G. E., Mulley, J. C. and Gecz, J. (1999). Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda. Nat. Genet. 22, 400-404.
8. Gelb, M., Scholten, J. D. and Sebolt-Leopold, J. (1998). Protein prenylation: from discovery to prospects for cancer treatment. Curr. Opin. Chem. Biol. 2, 40-48.
9. Gonzalez, L. C., Jr, Weis, W. I. and Scheller, R. H. (2001). A novel SNARE N-terminal domain revealed by the crystal structure of Sec22b. J. Biol. Chem. 276, 24203-24211.
10. Guan, K. L. and Dixon, J. E. (1991). Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem. 192, 262-267.
11. Hancock, J. F., Magee, A. I., Childs, J. E. and Marshall, C. J. (1989). All Ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57, 1167-1177.
12. Hasegawa, H., Zinsser, S., Rhee, Y., Vik-Mo, E. O., Davanger, S. and Hay, J. C. (2003). Mammalian Ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain. Mol. Biol. Cell 14, 698-720.
13. Hay, J. C. (2001). SNARE complex structure and function. Exp. Cell Res. 271, 10-21.
14. Hay, J. C., Hirling, H. and Scheller, R. H. (1996). Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus. J. Biol. Chem. 271, 5671-5679.
15. Hay, J. C., Chao, D. S., Kuo, C. S. and Scheller, R. H. (1997). Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell 89, 149-158.
16. Horton, R., Hunt, H., Ho, S., Pullen, J. and Pease, L. (1989). Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77, 61-68.
17. Jang, S. B., Kim, Y. G., Cho, Y. S., Suh, P. G., Kim, K. H. and Oh, B. H. (2002). Crystal structure of SEDL and its implications for a genetic disease spondyloepiphyseal dysplasia tarda. J. Biol. Chem. 277, 49863-49869.
18. Liu, Y. and Barlowe, C. (2002). Analysis of Sec22p in ER/Golgi transport reveals cellular redundancy in SNARE protein function. Mol. Biol. Cell 13, 3314-3324.
19. Martinez-Arca, S., Rudge, R., Vacca, M., Raposo, G., Camonis, J., Proux-Gillardeaux, V., Daviet, L., Formstecher, E., Hamburger, A., Filippini, F. et al. (2003). A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc. Natl. Acad. Sci. USA 100, 9011-9016.
20. McNew, J. A., Sogaard, M., Lampen, N. M., Machida, S., Ye, R. R., Lacomis, L., Tempst, P., Rothman, J. E. and Sollner, T. H. (1997). Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J. Biol. Chem. 272, 17776-17783.
21. Munson, M., Chen, X., Cocina, A. E., Schultz, S. M. and Hughson, F. M. (2000). Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly. Nat. Struct. Biol. 7, 894-902.
22. Prekeris, R., Klumperman, J. and Scheller, R. H. (2000). Syntaxin 11 is an atypical SNARE abundant in the immune system. Eur. J. Cell Biol. 79, 771-780.
23. Sacher, M. and Ferro-Novick, S. (2001). Purification of TRAPP from Saccharomyces cerevisiae and identification of its mammalian counterpart. Methods Enzymol. 329, 234-241.
24. Steegmaier, M., Oorschot, V., Klumperman, J. and Scheller, R. H. (2000). Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics. Mol. Biol. Cell 11, 2719-2731.
25. Tang, B. L., Low, D. Y. and Hong, W. (1998). Hsec22c: a homolog of yeast Sec22p and mammalian rSec22a and mSec22b/ERS-24. Biochem. Biophys. Res. Commun. 243, 885-891.
26. Tochio, H., Tsui, M. M., Banfield, D. K. and Zhang, M. (2001). An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p. Science 293, 698-702.
27. Tsui, M. M. and Banfield, D. K. (2000). Yeast Golgi SNARE interactions are promiscuous. J. Cell Sci. 113, 145-152.
28. Ungar, D. and Hughson, F. M. (2003). Snare protein structure and function. Annu. Rev. Cell Dev. Biol. 19, 493-517.
29. Ungermann, C., von Mollard, G. F., Jensen, O. N., Margolis, N., Stevens, T. H. and Wickner, W. (1999). Three v-SNAREs and two t-SNAREs, present in a pentameric cis-SNARE complex on isolated vacuoles, are essential for homotypic fusion. J. Cell Biol. 145 1435-1442.
30. Webb, Y., Hermida-Matsumoto, L. and Resh, M. D. (2000). Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J. Biol. Chem. 275, 261-270.
31. Xu, D., Joglekar, A., Williams, A. and Hay, J. C. (2000). Subunit structure of a mammalian ER/Golgi SNARE complex. J. Biol. Chem. 275, 39631-39639.
32. Zeng, Q., Subramaniam, V. N., Wong, S. H., Tang, B. L., Parton, R. G., Rea, S., James, D. E. and Hong, W. (1998). A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane. Mol. Biol. Cell 9, 2423-2437.