SNARE complex structure and function

Experimental Cell Research

Volumn 271, Issue 1, 2001, Pages 10-21

  Hay, Jesse C ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SNARE PROTEIN; SYNTAXIN;

AMINO TERMINAL SEQUENCE; CATALYSIS; COMPLEX FORMATION; MEMBRANE FUSION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN STRUCTURE; REGULATORY MECHANISM; SHORT SURVEY;

EID: 0035890255     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5368     Document Type: Article

References (100)

1. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution
2. The synaptic SNARE complex is a parallel four-stranded helical bundle
3. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors
4. Structural changes are associated with soluble n-ethylmaleimide-sensitive fusion protein attachment protein receptor complex formation
5. SNAP receptors implicated in vesicle targeting and fusion
6. SNARE complex formation is triggered by ca2+ and drives membrane fusion
7. Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs
8. Defining the functions of trans-SNARE pairs
9. Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion
10. SNARE interactions are not selective. Implications for membrane fusion specificity
11. Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties
12. Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
13. Functional analysis of conserved structural elements in yeast syntaxin vam3p
14. Activity-dependent changes in partial VAMP complexes during neurotransmitter release
15. Membrane tethering and fusion in the secretory and endocytic pathways
16. A genomic perspective on membrane compartment organization
17. Functional architecture of an intracellular membrane t-SNARE
18. A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function
19. Subunit structure of a mammalian ER/Golgi SNARE complex
20. Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as q- and r-SNAREs
21. Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25
22. SNAREs contribute to the specificity of membrane fusion
23. Testing the 3Q:1R "rule": Mutational analysis of the ionic "zero" layer in the yeast exocytic SNARE complex reveals no requirement for arginine
24. Exocytosis requires asymmetry in the central layer of the SNARE complex
25. Genetic interactions with the yeast Q-SNARE Vtil reveal novel functions for the R-SNARE Ykt6
26. Cocrystal structure of synaptobrevin-2 bound to botulinum neurotoxin type B at 2.0 A resolution
27. Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling
28. A conformational switch in syntaxin during exocytosis: Role of munc18
29. The neuronal t-SNARE complex is a parallel four-helix bundle
30. Folding intermediates of SNARE complex assembly
31. Inhibition of SNARE complex assembly differentially affects kinetic components of exocytosis
32. Regulation of SNARE complex assembly by an N-terminal domain of the t-SNARE Sso1p
33. Topological restriction of SNARE-dependent membrane fusion
34. Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly
35. Protease resistance of syntaxin-SNAP-25-VAMP complexes. Implications for assembly and structure
36. Three SNARE complexes cooperate to mediate membrane fusion
37. A conserved membrane-spanning amino acid motif drives homomeric and supports heteromeric assembly of presynaptic SNARE proteins
38. The C terminus of SNAP-25 is essential for ca(2+)-dependent binding of synaptotagmin to SNARE complexes
39. Synaptotagmin mutants reveal essential functions for the C2B domain in ca2+-triggered fusion and recycling of synaptic vesicles in vivo
40. SNARE complex oligomerization by synaphin/complexin is essential for synaptic vesicle exocytosis
41. Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1a
42. Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly
43. Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation
44. Vam3p structure reveals conserved and divergent properties of syntaxins
45. Rapid and efficient fusion of phospholipid vesicles by the alpha- helical core of a SNARE complex in the absence of an N-terminal regulatory domain
46. Three-dimensional structure of the neuronal-sec1-syntaxin la complex
47. Sec1p binds to SNARE complexes and concentrates at sites of secretion
48. Nsec1 binds a closed conformation of syntaxin 1a
49. A novel SNARE N-terminal domain revealed by the crystal structure of sec22b
50. An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p
51. Role of tetanus neurotoxin insensitive vesicle-associated membrane protein (ti-VAMP) in vesicular transport mediating neurite outgrowth
52. An isoform of the Golgi t-SNARE, syntaxin 5, with an endoplasmic reticulum retrieval signal
53. Phox domain interaction with ptdins(3)p targets the Vam7 t-SNARE to vacuole membranes
54. Identification of domains required for developmentally regulated SNARE function in Saccharomyces cerevisiae
55. SNAREs and NSF in targeted membrane fusion
56. Molecular mechanisms of platelet exocytosis: Role of SNAP-23 and syntaxin 2 in dense core granule release
57. Syntaxin 2 splice variants exhibit differential expression patterns, biochemical properties and subcellular localizations
58. Localization of a syntaxin isoform, syntaxin 2, to the acrosomal region of rodent spermatozoa
59. A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina
60. Transport and function of syntaxin 3 in human epithelial intestinal cells
61. Soluble NSF attachment protein receptors (SNAREs) in rbl-2h3 mast cells: Functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment
62. Synip: A novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes
63. Proteins of the exocytotic core complex mediate platelet alpha-granule secretion. Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4
64. Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs
65. Role of vesicle-associated syntaxin 5 in the assembly of pre-Golgi intermediates
66. Syntaxin 7, a novel syntaxin family member associated with the early endosomal compartment
67. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking
68. Syntaxin 7 and VAMP-7 are soluble n-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages
69. Syntaxin 7 is localized to late endosome compartments, associates with VAMP 8, and is required for late endosome-lysosome fusion
70. Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network
71. Syntaxin 11 is an atypical SNARE abundant in the immune system
72. Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking
73. The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency
74. Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes
75. Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins
76. Syntaxin-16, a putative Golgi t-SNARE
77. Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics
78. Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking
79. A 29-kilodalton Golgi soluble n-ethylmaleimide-sensitive factor attachment protein receptor (vti1-rp2) implicated in protein trafficking in the secretory pathway
80. The SNARE vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex
81. Association of a novel pdz domain-containing peripheral Golgi protein with the Q-SNARE protein syntaxin 6
82. Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis
83. The rab5 effector EEA1 interacts directly with syntaxin-6
84. Preferential association of syntaxin 8 with the early endosome
85. Syntaxin 10: A member of the syntaxin family localized to the trans-Golgi network
86. Gs15, a 15-kilodalton Golgi soluble n-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1
87. SNAP-23 is located in the basolateral plasma membrane of rat pancreatic acinar cells
88. SNAP-23 requirement for transferrin recycling in streptolysin-O- permeabilized Madin-Darby canine kidney cells
89. Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells
90. Three novel proteins of the syntaxin/SNAP-25 family
91. GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6
92. Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking
93. A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane
94. Subcellular localization of tetanus neurotoxin-insensitive vesicle-associated membrane protein (VAMP)/VAMP7 in neuronal cells: Evidence for a novel membrane compartment
95. Vamp-7 mediates vesicular transport from endosomes to lysosomes
96. Raft association of SNAP receptors acting in apical trafficking in Madin-Darby canine kidney cells
97. Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta ceils and its physiological function in exo- endocytosis of secretory granules
98. SNARE protein trafficking in polarized MDCK cells
99. Ykt6 forms a SNARE complex with syntaxin 5, GS28 and bet1 and participates in a late stage in ER-Golgi transport
100. Tomosyn: A syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process