Quantitative analysis of interconnectivity of porous biodegradable scaffolds with micro-computed tomography

Journal of Biomedical Materials Research - Part A

Volumn 71, Issue 2, 2004, Pages 258-267

  Moore, Michael J ^a   Jabbari, Esmaiel ^a,b   Ritman, Erik L ^a   Lu, Lichun ^a,b   Currier, Bradford L ^b   Windebank, Anthony J ^b   Yaszemski, Michael J ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Image analysis; Interconnectivity; Microstructure; Porosity; Scaffold

Indexed keywords

BIODEGRADATION; CELLS; CHEMICAL ANALYSIS; IMAGE ANALYSIS; PARAMETER ESTIMATION; POROUS MATERIALS; SCAFFOLDS; TISSUE; TOMOGRAPHY;

CELL MIGRATION; INTERCONNECTIVITY; POROGEN FRACTIONS; TISSUE GROWTH;

BIOMEDICAL ENGINEERING;

ALGORITHM; ARTICLE; BIODEGRADABLE IMPLANT; CELL MIGRATION; COMPUTER ASSISTED TOMOGRAPHY; IMAGE ANALYSIS; LEACHING; OPTICAL RESOLUTION; POROSITY; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; THREE DIMENSIONAL IMAGING; TISSUE REGENERATION; VALIDATION PROCESS;

ALGORITHMS; BIOCOMPATIBLE MATERIALS; MICROSCOPY, ELECTRON, SCANNING; POROSITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 5444262074     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.30138     Document Type: Article

References (24)

1. Yang S, Leong KF, Du Z, Chua CK. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng 2001;7:679-689.
2. Hui PW, Leung PC, Sher A. Fluid conductance of cancellous bone graft as a predictor for graft-host interface healing. J Biomech 1996;29:123-132.
3. Holy CE, Fialkov JA, Davies JE, Shoichet MS. Use of a biomimetic strategy to engineer bone. J Biomed Mater Res 2003;65A: 447-453.
4. Murphy WL, Dennis RG, Kileny JL, Mooney DJ. Salt fusion: an approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Eng 2002;8:43-52.
5. Martin EA, Ritman EL, Turner RT. Time course of epiphyseal growth plate fusion in rat tibiae. Bone 2003;32:261-267.
6. Mawatari T, Miura H, Higaki H, Kurata K, Moro-oka T, Murakami T, Iwamoto Y. Quantitative analysis of three-dimensional complexity and connectivity changes in trabecular microarchitecture in relation to aging, menopause, and inflammation. J Orthop Sci 1999;4:431-438.
7. Ritman EL, Bolander ME, Fitzpatrick LA, Turner RT. Micro-CT imaging of structure-to-function relationship of bone microstructure and associated vascular involvement. Technol Health Care 1998;6:403-412.
8. Jorgensen SM, Demirkaya O, Ritman EL. Three-dimensional imaging of vasculature and parenchyma in intact rodent organs with X-ray micro-CT. Am J Physiol 1998;275:H1103-H1114.
9. Wan SY, Kiraly AP, Ritman EL, Higgins WE. Extraction of the hepatic vasculature in rats using 3-D micro-CT images. IEEE Trans Med Imaging 2000;19:964-971.
10. Lin AS, Barrows TH, Cartmell SH, Guldberg RE. Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. Biomaterials 2003;24:481-489.
11. Taboas JM, Maddox RD, Krebsbach PH, Hollister SJ. Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer-ceramic scaffolds. Biomaterials 2003;24:181-194.
12. Zeltinger J, Sherwood JK, Graham DA, Mueller R, Griffith LG. Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition. Tissue Eng 2001;7:557-572.
13. Filmon R, Retailleau-Gaborit N, Grizon F, Galloyer M, Cincu C, Basle MF, Chappard D. Non-connected versus interconnected macroporosity in poly(2-hydroxyethyl methacrylate) polymers. An X-ray microtomographic and histomorphometric study. J Biomater Sci Polym Ed 2002;13:1105-1117.
14. Kharas GB, Kamenetsky M, Simantirakis J, Beinlich KC, Rizzo AMT, Caywood GA, Watson K. Synthesis and characterization of fumarate-based polyesters for use in bioresorbable bone cement composites. J Appl Polym Sci 1997;66:1123-1137.
15. Fisher JP, Holland TA, Dean D, Engel PS, Mikos AG. Synthesis and properties of photocross-linked poly(propylene fumarate) scaffolds. J Biomater Sci Polym Ed 2001;12:673-687.
16. Witt ST, Riedel CH, Goessl M, Chmelik MS, Ritman EL. Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation. In: Yaffe MJ, Antonuk LE, editors. Medical Imaging 2003: Proc SPIE 2003. p 720-727. (Physics of Medical Imaging; 5030).
17. Feldkamp LA, Goldstein SA, Parfitt AM, Jesion G, Kleerekoper M. The direct examination of three-dimensional bone architecture in vitro by computed tomography. J Bone Miner Res 1989;4:3-11.
18. Robb RA, Hanson DP, Karwoski RA, Larson AG, Workman EL, Stacy MC. Analyze: a comprehensive, operator-interactive software package for multidimensional medical image display and analysis. Comput Med Imaging Graph 1989;13:433-454.
19. Hanson DP, Robb RA, Aharon S, Augustine KE, Cameron BM, Camp JJ, Karwoski RA, Larson AG, Stacy MC, Workman EL. New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images. J Digit Imaging 1997;10 (Suppl 1):229-230.
20. Camp JJ, Hann CR, Johnson DH, Tarara JE, Robb RA. Three-dimensional reconstruction of aqueous channels in human trabecular meshwork using light microscopy and confocal microscopy. Scanning 1997;19:258-263.
21. Lin CL, Miller JD. Network analysis of filter cake pore structure by high resolution x-ray microtomography. In: 1st World Congress on Industrial Process Tomography; 1999 April 14-17; Buxton, UK.
22. Haralick RM, Sternberg SR, Zuang X. Image analysis using mathematical morphology. IEEE Transactions on Pattern Analysis and Machine Intelligence 1987;PAMI-9:553-550.
23. Pal NR, Pal SK. A review on image segmentation techniques. Pattern Recognition 1993;26:1277-1294.
24. Rajagopalan S, Yaszemski MJ, Robb RA. Evaluation of thresholding techniques for segmenting scaffold images in tissue engineering. In: Sonka M, Fitzpatric JM, editors. Medical Imaging 2004: Proc SPIE 2004. p 1456-1465. (Image Processing; 5370).