Down-regulation of the prostate specific antigen promoter by p53 in human prostate cancer cells

Journal of Urology

Volumn 172, Issue 5 I, 2004, Pages 2035-2039

  Tsui, Ke Hung ^a   Chang, Phei Lang ^a   Lin, Han Tze ^b   Juang, Horng Heng ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b NONE

Author keywords

Doxorubicin; Promoter regions (genetics); Prostate; Prostate specific antigen; Prostatic neoplasms

Indexed keywords

DOXORUBICIN; PROSTATE SPECIFIC ANTIGEN; PROTEIN P53;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE VECTOR; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS;

EID: 5444227752     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000138053.78518.b2     Document Type: Article

References (19)

1. Abbas, F. and Scardino, P. T.: The natural history of clinical prostate carcinoma. Cancer, 80: 827, 1997
2. Siles, E., Villalobos, M., Valenzuela, M. T., Nunez, M. I., Gordon, A., McMillan, T. J. et al: Relationship between p53 status and radiosensitivity in human tumour cell lines. Br J Cancer, 73: 581, 1996
3. Osman, I., Drobjnak, M., Fazzari, M., Ferrara, J., Sher, H. I. and Cordon-Cardo, C.: Inactivation of the p53 pathway in prostate cancer: impact on tumor progression. Clin Cancer Res, 5: 2082, 1999
4. Colman, M. S., Afshari, C. A. and Barrett, J. C.: Regulation of p53 stability and activity in response to genotoxic stress. Mutat Res, 462: 179, 2000
5. Isaacs, W. B., Carter, B. S. and Ewing, C. M.: Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles. Cancer Res, 51: 4716, 1991
6. Shenk, J. L., Fisher, C. J., Chen, S. Y., Zhou, X. F., Tillman, K. and Shemshedini, L.: p53 represses androgen-induced transactivation of prostate-specific antigen by disrupting hAR amino- to carboxyl-terminal interaction. J Biol Chem, 276: 38472, 2001
7. Gurova, K. V., Roklin, Q. W., Krivokrysenko, V. I., Chumakov, P. M., Cohen, M. B., Feinstein, E. et al: Expression of prostate specific antigen (PSA) is negatively regulated by p53. Oncogene, 21: 153, 2002
8. Horoszewicz, J. S., Leong, S. S., Kawinski, E., Karr, J. P., Rosenthal, H., Chu, T. M. et al: LNCaP model of human prostate carcinoma. Cancer Res, 43: 1809, 1983
9. Weijerman, P. C., Konig, J. J., Wong, S. T., Niesters, H. G. and Peehl, D. M.: Lipofection-mediated immortalization of human prostatic epithelial cells of normal and malignant origin using human papillomavirus type 18 DNA. Cancer Res, 54: 5579, 1994
10. Matlashewski, G., Lamb, P., Pim, D., Pencock, J., Crawford, L. and Benchimol, S.: Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene. EMBO J, 3: 3257, 1984
11. Lee, S. E., Jin, R. J., Lee, S. G., Yoon, S. J., Park, M. S., Heo, D. S. et al: Development of a new plasmid vector with PSA-promoter and enhancer expressing tissue-specificity in prostate carcinoma cell lines. Anticancer Res, 20: 417, 2000
12. el-Deiry, W. S.: Regulation of p53 downstream genes. Semin Cancer Biol, 8: 345, 1998
13. Sanda, M. G., Ayyagari, S. R., Jaffee, E. M., Epstein, J. I., Clift, S. L., Cohen, L. K. et al: Demonstration of a rational strategy for human prostate cancer gene therapy. J Urol, 151: 622, 1994
14. Leith, J. T., Quarante, L., Padfield, G., Michelson, S. and Hercbergs, A.: Radiobiological studies of PC-3 and DU-145 human prostate cancer cells: x-ray sensitivity in vitro and hypoxic fractions of xenografted tumors in vivo. Int J Radiat Oncol Biol Phys, 25: 283, 1993
15. Deweese, T. L., Shipman, J. M., Dillehay, L. E. and Nelson, W. G.: Sensitivity of human prostatic carcinoma cell lines to low dose rate radiation exposure. J Urol, 159: 591, 1998
16. Girinsky, T., Koumenis, C., Graeber, T. G., Peehl, D. M. and Giaccia, A. J.: Attenuated response of p53 and p21 in primary cultures of human prostatic epithelial cells exposed to DNA-damaging agents. Cancer Res, 55: 3726, 1995
17. Martinez, L. A., Yang, J., Vazquez, E. S., Rodriquez-Vargas M. del C., Olive, M., Hsieh, J. T. et al: p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells. Carcinogenesis, 23: 1289, 2002
18. Marks, L. S., DiPaola, R. S., Nelson, P., Chen, S., Heber, D., Belldegrun, A. S. et al: PC-SPES: herbal formulation for prostate cancer. Urology, 60: 369, 2002
19. Narayanan, B. A., Narayanan, N. K., Re, G. G. and Nixon, D. W.: Differential expression of genes induced by resveratrol in LNCaP cells p53-mediated molecular targets. Int J Cancer, 104: 204, 2003