Urea-mediated regioselective nitration of (20s)-camptothecin

Synthetic Communications

Volumn 34, Issue 18, 2004, Pages 3443-3448

  Puri, S C ^a   Handa, G ^a   Suri, O P ^a   Qazi, G N ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

9 nitro (20S) camptothecin; Anticancer drugs; Camptothecin; Nitration

Indexed keywords

CAMPTOTHECIN DERIVATIVE; UREA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; NITRATION; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR REGRESSION;

EID: 5444224388     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-200036276     Document Type: Article

References (8)

1. Puri, S.C.; Handa, G.; Gupta, R.K.; Gupta, V.K.; Srivastava, T.N.; Somal, P.; Sharma, S.N. Quantitation of camptothecin in Nothapodytes foetida. J. Indian Chem. Soc. 1997, 36B, 25.
2. Sharma, S.N.; Puri, S.C.; Srivastava, T.N.; Handa, G.; Koul, B. Enhancement of seed germination in Nothapodytes foetida. J. Med. Arom. Plant Sci. 2000, 22, 206.
3. Giovanella, B.C.; Stehlin, J.S.; Wall, M.E.; Wani, M.C.; Nicholas, A.W.; Liu, L.F.; Silber, R.; Potmesil, M. Highly effective topoisomerase-I targeted chemotherapy of human colon cancer in xenografts. Sciences (N.Y. Acad. Sci.) 1989, 246, 1046.
4. Pantazis, P.; Harris, N.; Mendoza, J.; Giovanella, B. Conversion of 9-nitro-camptothecin to 9-amino-camptothecin by human blood cells in vitro. Eur. J. Haematol. 1994, 53, 246.
5. Wani, M.C.; Nicholas, A.W.; Wall, M.E. Plant antitumor agents: synthesis and antileukemic activity of camptothecin analogues. J. Med. Chem. 1986, 29, 2358.
6. Cao, Z.S.; Armstrong, K.; Shaw, M.; Petry, E.; Harris, N. Nitration of camptothecin with various inorganic nitrate salts in concentrate sulfuric acid: a new preparation of anticancer drug 9-nitrocamptothecin. Synthesis 1998, 1724.
7. Ferrarini, P.L.; Mori, C.; Badawneh, M.; Manera, C; Martinelli, A.; Micell, M.; Romagnolic, F.; Saccomanni, G. Heterocyclic vinyl ether VII. Rearrangement of 1,4, dithiadiene ring system. Eur. J. Med. Chem. 1997, 32, 955.
8. Takemoto, K.; Sonoda, N. In Inclusion Compounds; Atwood, J.L., Davies, J.E., Macnicol, D.D., Eds.; Academic Press: NY, 1984; Vol. 2, 47.