Conformational changes in the antibody constant domains upon hapten-binding

Molecular Immunology

Volumn 42, Issue 1, 2005, Pages 9-18

  Sagawa, Takuma ^a   Oda, Masayuki ^a   Morii, Hisayuki ^b   Takizawa, Hisao ^c   Kozono, Haruo ^a   Azuma, Takachika ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antibody; Antigen; Conformational change; Rodent

Indexed keywords

ANTIBODY; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; HAPTEN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN RECEPTOR; STAPHYLOCOCCUS PROTEIN A; STAPHYLOCOCCUS PROTEIN G; UNCLASSIFIED DRUG;

ANTIBODY TITER; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CALORIMETRY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; TITRIMETRY;

ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, BACTERIAL; CALORIMETRY; HAPTENS; IMMUNOGLOBULIN HEAVY CHAINS; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; STAPHYLOCOCCAL PROTEIN A; SURFACE PLASMON RESONANCE;

BACTERIA (MICROORGANISMS); RODENTIA;

EID: 5444224341     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2004.07.004     Document Type: Article

References (30)

1. L.M. Amzel, and R. Poljak Three-dimensional structure of immunoglobulins Ann. Rev. Biochem. 48 1979 961 997
2. L. Björck, and G. Kronvall Purification and some properties of streptococcal protein G, a novel IgG-binding reagent J. Immunol. 133 1984 969 973
3. D.R. Davies, and H. Metzger Antibody-antigen complexes Annu. Rev. Immunol. 1 1983 87 117
4. J. Deisenhofer Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-Å resolution Biochemistry 20 1981 2361 2370
5. J.P. Derrick, and D.B. Wigley Crystal structure of a streptococcal protein G domain bound to an Fab fragment Nature 359 1992 752 754
6. J.P. Derrick, and D.B. Wigley The third IgG-binding domain from streptococcal protein G an analysis by X-ray crystallography of the structure alone and in a complex with Fab J. Mol. Biol. 243 1994 906 918
7. P.L. Ey, S.J. Prowse, and C.R. Jenkin Isolation of pure IgG1 IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose Biochemistry 15 1978 429 436
8. M. Graille, E.A. Stura, A.L. Corper, B.J. Sutton, M.J. Taussig, J.B. Charbonnier, and G.J. Silverman Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity Proc. Natl. Acad. Sci. U.S.A. 97 2000 5399 5404
9. D.C. Hanson, J. Yguerabide, and V.N. Schumaker Segmental flexibility of immunoglobulin G antibody molecules in solution: a new interpretation Biochemistry 20 1981 6842 6852
10. L.J. Harris, S.B. Larson, K.W. Hasel, and A. McPherson Refined structure of an intact IgG2a monoclonal antibody Biochemistry 36 1997 1581 1597
11. L.J. Harris, E. Skaletsky, and A. McPherson Crystallographic structure of an intact IgG1 monoclonal antibody J. Mol. Biol. 275 1998 861 872
12. B. Jansson, M. Uhlén, and P.A. Nygren All individual domains of staphylococcal protein A show Fab binding FEMS Immunol. Med. Microbiol. 20 1998 69 78
13. R. Jefferis, J. Lund, and J.D. Pound IgG-Fc-mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation Immunol. Rev. 163 1998 59 76
14. L. Jendeberg, B. Persson, R. Andersson, R. Karlsson, M. Uhlén, and B. Nilsson Kinetic analysis of the interaction between protein A domain variants and human Fc using plasmon resonance detection J. Mol. Rec. 8 1995 270 278
15. R. Karlsson, J.A. Mo, and R. Holmdahl Binding of autoreactive mouse anti-type II collagen antibodies derived from the primary and the secondary immune response investigated with the biosensor technique J. Immunol. Meth. 188 1995 63 71
16. J.J. Langone Protein A of Staphylococcus aureus and related immunoglobulin receptors produced by streptococci and pneumonococci Adv. Immunol. 32 1982 157 252
17. L.-Y. Lian, I.L. Barsukov, J.P. Derrick, and G.C. Roberts Mapping the interactions between streptococcal protein G and the Fab fragment of IgG in solution Nat. Struct. Biol. 1 1994 355 357
18. M. Marquart, J. Deisenhofer, and R. Huber Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution J. Mol. Biol. 141 1980 369 391
19. D.P. Meininger, M. Rance, M.A. Starovasnik, W.J. Fairbrother, and N.J. Skelton Characterization of the binding interface between the E-D domain of staphylococcal protein A and an antibody Fv-fragment Biochemistry 39 2000 26 36
20. M. Oda, and T. Azuma Reevaluation of stoichiometry and affinity/avidity in interactions between anti-hapten antibodies and mono- or multi-valent antigens Mol. Immunol. 37 2000 1111 1122
21. M. Oda, H. Kozono, H. Morii, and T. Azuma Evidence of allosteric conformational changes in the antibody constant region upon antigen binding Int. Immunol. 15 2003 417 426
22. V.T. Oi, T.M. Vuong, R. Hardy, J. Reidler, J. Dangl, L.A. Herzenberg, and L. Strye Correlation between segmental flexibility and effector function of antibodies Nature 307 1984 136 140
23. G.J. Silverman B-cell superantigens Immunol. Today 18 1997 379 386
24. E.W. Silverton, M.A. Navia, and D.R. Davies Three-dimensional structure of an intact human immunoglobulin Proc. Natl. Acad. Sci. U.S.A. 74 1977 5140 5144
25. M.A. Starovasnik, M.P. O'Connell, W.J. Fairbrother, and R.F. Kelley Antibody variable region binding by staphylococcal protein A: thermodynamic analysis and location of the Fv binding site on E-domain Protein Sci. 8 1999 1423 1431
26. T. Sun, M.R. Clark, and U. Storb A point mutation in the constant region of Ig lambda 1 prevents normal B cell development due to defective BCR signaling Immunity 16 2002 245 255
27. M. Uhlén, B. Guss, B. Nilsson, S. Gatenbeck, L. Philipson, and M. Lindberg Complete sequence of the staphylococcal gene encoding protein A: a gene evolved through multiple duplications J. Biol. Chem. 259 1984 1695 1702
28. R.C. Valentine, and N.M. Green Electron microscopy of an antibody-hapten complex J. Mol. Biol. 27 1967 615 617
29. L.A. Wilson, and R.L. Stanfield Antibody-antigen interactions: new structures and new conformational changes Curr. Opin. Struct. Biol. 4 1994 857 867
30. J. Yguerabide, H.F. Epstein, and L. Stryer Segmental flexibility in an antibody molecule J. Mol. Biol. 51 1970 573 590