Serum prostate-specific antigen concentration is increased in acromegalic women

Journal of Endocrinological Investigation

Volumn 27, Issue 7, 2004, Pages 643-647

  Manetti, L ^a   Lupi, I ^a   Genovesi, M ^a   Morselli, L ^a   Grasso, L ^a   Nencetti, C ^a   Gasperi, M ^a   Bogazzi, F ^a   Bartalena, L ^b   Martino, E ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

3 androstanediol; Acromegaly; DHEAS; GH; Hyperandrogenism; IGF I; PSA; Testosterone

Indexed keywords

ANDROSTANEDIOL; ANGIOPEPTIN; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; OCTREOTIDE; PRASTERONE SULFATE; PROSTATE SPECIFIC ANTIGEN; SOMATOSTATIN DERIVATIVE; TESTOSTERONE;

ACROMEGALY; ADULT; AGED; ARTICLE; BLOOD SAMPLING; BODY MASS; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME IMMUNOASSAY; FEMALE; HIRSUTISM; HUMAN; POSTMENOPAUSE; PREMENOPAUSE; REMISSION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SURGICAL TECHNIQUE;

EID: 5444221926     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03347496     Document Type: Article

References (28)

1. Clements JA. The glandular kallicrein family of enzymes: tissue-specific expression and hormonal regulation. Endocr Rev 1989, 10: 393-419.
2. McCormack RT, Rittenhouse HG, Finlay JA, et al. Molecular forms of prostate specific antigen and the human kallicrein gene family: a new era. Urology 1995, 45: 729-44.
3. Wang MC, Valenzuele LA, Murphy GP, Chu TM. Purification of human prostate specific antigen. Invest Urol 1979, 17: 159-63.
4. Papsidero LD, Wang MC, Valenzuela LA, Murphy GP, Chu TM. A prostate antigen in sera of prostatic cancer patients. Cancer Res 1980, 40: 2428-32.
5. Catalona WJ, Smith DS, Ratliff TL, et al. Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med 1991, 324: 1156-61.
6. Diamandis EP, Yu H. New biological functions of prostate specific antigen? J Clin Endocrinol Metab 1995, 80: 1515-7.
7. Diamandis EP, Yu H. Nonprostatic sources of prostate-specific antigen. Urol Clin North Am 1997, 24: 275-82.
8. Yu H, Diamandis EP. Measurement of serum prostate specific antigen levels in females and in prostatectomized males with an ultrasensitive immunoassay technique. J Urol 1995, 153: 1004-8.
9. Diamandis EP, Yu H, Melegos DN. Ultrasensitive prostate specific antigen assays and their clinical application. Clin Chem 1996, 42: 853-7.
10. Melegos DN, Yu H, Ashok M, Wang C, Stanczyk F, Diamandis EP. Prostate-specific antigen in female serum, a potential new marker of androgen excess. J Clin Endocrinol Metab 1997, 82: 777-80.
11. Escobar-Morreale HF, Serrano-Gotarredona J, Avila S, Villar-Palasì J, Varela C, Sancho J. The increased circulating prostate-specific antigen concentrations in women with hirsutism do not respond to acute changes in adrenal or ovarian function. J Clin Endocrinol Metab 1998, 83: 2580-4.
12. Negri C, Tosi F, Dorizzi R, et al. Antiandrogen drugs lower serum prostate-specific antigen (PSA) levels in hirsute subjects: evidence that serum PSA is a marker of androgen action in women. J Clin Endocrinol Metab 2000, 85: 81-4.
13. Escobar-Morreale HF, Avila S, Sancho J. Serum prostate-specific antigen concentrations are not useful for monitoring the treatment of hirsutism with oral contraceptive pills. J Clin Endocrinol Metab 2000, 85: 2488-92.
14. Manetti L, Lupi I, Bogazzi F, et al. Prostate-specific antigen is increased in female patients with Cushing's disease. J Endocrinol Invest 2002, 25: 29-31.
15. Cara JF, Rosenfield RL. Insulin-like growth factor I and insulin potentiating luteinizing hormone-induced androgen synthesis by rat ovarian thecalinterstizial cells. Endocrinology 1988, 123: 733-9.
16. Dunaif A. Insulin resistance and the polycistic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997, 18: 774-800.
17. Wass JAH. Dynamic testing in the diagnosis and follow-up of patients with acromegaly. J Endocrinol Invest 2003, 26: 48-53.
18. Luke MC, Coffey DS. Human androgen receptors binding to the androgen response element of prostate specific antigen. J Androl 1994, 15: 41-51.
19. Labrie F, Luu-The V, Labrie C, et al. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiadrosterone. Endocr Rev 2003, 24: 152-82.
20. Nestler JE, Jakubowicz DJ, de Vargas AF, Brik C, Quintero N, Medina F. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J Clin Endocrinol Metab 1998, 83: 2001-5.
21. Poretsky L. On the paradox of insulin-induced hyperandrogenism in insulin-resistant states. Endocr Rev 1991, 12: 3-13.
22. Colao A, Marzullo P, Ferone D, et al. Prostatic hyperplasia: an unknown feature of acromegaly. J Clin Endocrinol Metab 1998, 83: 775-9.
23. Rajah R, Valetinis B, Cohen P. Insulin-like growth factor-I and -II in human benign prostatic hyperplasia: relationship with binding proteins 2 and 3 and androgens. Steroids 1997, 272: 12181-8.
24. Barreca A, Minuto F. Somatomedins: chemical and functional characteristics of the different molecular forms. J Endocrinol Invest 1989, 12: 279-94.
25. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995, 16: 3-34.
26. Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG. Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab 1992, 75: 1046-53.
27. Plymate SR, Rosen CJ, Paulsen CA, et al. Proteolysis of insulin-like growth factor-binding protein-3 in the male reproductive tract. J Clin Endocrinol Metab 1996, 81: 618-24.
28. Wernert N, Albrech M, Sesterhenn I, et al. The "female prostate". Location, morphology, immunohistochemical characteristics and significance. Eur Urol 1992, 22: 64-9.